Developing and Testing the Opioid Rapid Response System

开发和测试阿片类药物快速反应系统

• 批准号: 10303574
• 负责人: Michael Hecht
• 金额: $ 4.22万
• 依托单位: REAL PREVENTION, LLC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10303574
• 关键词: Address; Area; Certification; Cessation of life; Cluster randomized trial; Collaborations; Communication; Communities; Community Networks; Coronavirus; Cost Effectiveness Analysis; County; Data; Death Rate; Development; Effectiveness; Emergency Situation; Emergency response; Evaluation; Evaluation Studies; Event; Expenditure; Facebook; Geography; Goals; Health Promotion; Health Promotion and Education; Health system; Heart failure; Indiana; Individual; Intervention; Interview; Knowledge; Life; Link; Literature; Mediator of activation protein; Modality; Modeling; Multimedia; Naloxone; Naloxone Training; Nature; Opioid; Oral cavity; Outcome; Overdose; Participant; Persons; Phase; Pilot Projects; Population; Prevention; Procedures; Protocols documentation; Public Health; Quasi-experiment; Radio; Randomized; Reaction Time; Reporting; Research; Research Personnel; Sampling; Savings; Science; Services; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Stroke; Surveys; System; Techniques; Technology; Testing; Time; Training; Training Programs; Universities; Urban Community; Washington; Work; arm; base; commune; communication theory; cost; cost effective; cost effectiveness; design; digital; efficacy testing; emergency service responder; evidence base; innovation; innovative technologies; lens; member; opioid epidemic; opioid mortality; opioid overdose; overdose death; posters; randomized controlled study; recruit; response; rural area; skills; social; social cognitive theory; social group; social media; usability; volunteer

This Phase I SBIR will develop and demonstrate the usability/feasibility of the Opioid Rapid Response System (OSSR) in order to reduce deaths and strain on emergency response systems from opioid overdoses. Opioid overdoses exact a tremendous cost in lives and expenditures due to incredible strain on emergency response systems. Naloxone has been developed to counteract overdoses. However, the nature of these events requires a rapid response, a situation that challenges emergency responders in both lightly populated rural areas as well as densely populated urban communities. PulsePoint has developed an app with the potential to obviate both concerns by linking responders to events through the 911 system. PulsePoint is already in place in 4,000 communities throughout the U.S. However, the app cannot accomplish these goals without being used by a large number of citizen responders who are both able to administer life-saving Naloxone and confident in their ability to do so. This project is designed to develop innovative and effective techniques for filling this gap. We build off of the Clark County Pilot Project conducted by members of our team that developed preliminary recruitment and training protocols for enabling citizen responders to utilize the PulsePoint App. Using communication theory, a technology-based recruitment protocol will be built around appeals to individuals (personal identity appeals) and others (communal appeals). Recruitment messages will be disseminated through diverse media channels, including social media, posters, radio announcement, and work-of-mouth. Social Cognitive Theory will be used to develop both online and face-to- face training to enable users to use the PulsePoint App, safely respond to calls, and administer Naloxone. An unblinded, two-arm, parallel group cluster-randomized trial with non-random cluster sampling will be conducted in two Indiana counties to establish the usability and feasibility of ORRS and its recruitment and training components. We anticipate recruiting and training 400 citizen responders. Pretest and posttest surveys will evaluate the training and as well as recruitment exposure through the various channels. County-level data on the number of events to which participant responded as well as lives saved also will be used to evaluate the intervention. A quasi- experimental design will compare the two recruitment strategies and the two training modalities. Project findings will be used to design and more extensive, two statewide evaluation studies (Indiana and Washington) that examine outcomes in numbers of lives saves as well as conducted a cost effectiveness analyses. The project has great promise for rapid and wide dissemination through the PulsePoint network of communities and has the potential to develop a model for community responses to similar public health events (e.g., coronavirus, stroke, heart failure).

第一阶段 SBIR 将开发并证明阿片类药物的可用性/可行性 快速反应系统（OSSR），以减少紧急情况下的死亡和压力 阿片类药物过量的反应系统。阿片类药物过量造成巨大损失 由于紧急响应系统的巨大压力，生命和支出受到影响。 纳洛酮的开发是为了对抗过量服用。然而，这些的性质 事件需要快速反应，这种情况对应急响应人员提出了挑战 既包括人口稀少的农村地区，也包括人口稠密的城市社区。 PulsePoint 开发了一款应用程序，可以通过链接消除这两个问题 通过 911 系统响应事件。 PulsePoint 已在 4,000 个地区部署 美国各地的社区但是，该应用程序无法实现这些目标 没有被大量公民响应者使用，他们都能够 管理救生纳洛酮，并对自己的能力充满信心。这个项目是 旨在开发创新和有效的技术来填补这一空白。我们建立 克拉克县试点项目由我们的团队成员进行，该项目开发了 初步招募和培训协议，使公民响应者能够利用 PulsePoint 应用程序。运用沟通理论，基于技术的招聘 协议将围绕对个人的吸引力（个人身份吸引力）和 其他（共同呼吁）。招聘信息将通过以下渠道发布 多种媒体渠道，包括社交媒体、海报、广播公告等 口耳相传。社会认知理论将用于开发在线和面对面的 进行面部培训，使用户能够使用 PulsePoint 应用程序、安全地接听电话，以及 给予纳洛酮。非盲、双臂、平行组整群随机试验 将在印第安纳州的两个县进行非随机整群抽样，以 建立 ORRS 及其招募和培训的可用性和可行性 成分。我们预计将招募和培训 400 名公民响应人员。预测试和 后测调查将通过以下方式评估培训和招聘情况 各种渠道。有关参与者参加的活动数量的县级数据 响应以及挽救的生命也将用于评估干预措施。一个准 实验设计将比较两种招募策略和两种培训 方式。项目成果将用于设计和更广泛的两个全州范围 评估研究（印第安纳州和华盛顿州），检查许多结果 挽救生命并进行成本效益分析。该项目有很大 承诺通过 PulsePoint 网络进行快速、广泛传播 社区，并有潜力开发社区响应模型 类似的公共卫生事件（例如冠状病毒、中风、心力衰竭）。