Physical Activity and Preservation of Cognitive Function

体力活动和认知功能的保护

• 批准号: 10302710
• 负责人: Priya Palta
• 金额: $ 36.83万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10302710
• 关键词: Address; Administrative Supplement; Adult; African American; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-Protein; Area; Atherosclerosis Risk in Communities; Attention; Award; Biochemical; Biochemical Pathway; Biological Assay; Biological Markers; Brain; Brain imaging; Brain region; Brain-Derived Neurotrophic Factor; Cerebrospinal Fluid; Cerebrovascular Disorders; Cognition; Cognitive; Cognitive aging; Cohort Studies; Communities; Competence; Complement; Data; Dementia; Disease Pathway; Doctor of Philosophy; Educational Curriculum; Elderly; Ensure; Epidemiologist; Epidemiology; Financial Hardship; Funding; Future; Geriatrics; Goals; Health; Healthcare Systems; Hippocampus (Brain); Impaired cognition; Impairment; Incidence; Individual; Insulin-Like Growth Factor I; Intervention; Lead; Life; Life Style; Light; Link; Longitudinal trends; Magnetic Resonance Imaging; Manuscripts; Measurement; Measures; Medicine; Mentors; Methods; Modality; Nerve Degeneration; Neural Pathways; Neurocognitive; Neurodegenerative Disorders; Neurology; Neuronal Plasticity; Neurosciences; North Carolina; Outcome; Parents; Participant; Pathway interactions; Pattern; Phase; Physical activity; Plasma; Population; Population Distributions; Population Sciences; Population Study; Postdoctoral Fellow; Publications; Publishing; Race; Reporting; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Sampling; Science; Scientist; Specimen; Structure; Supervision; Testing; Training; United States National Institutes of Health; Universities; Visit; Woman; Work; active lifestyle; adjudicate; age related; aging population; base; biracial; brain abnormalities; cardiovascular disorder epidemiology; cardiovascular disorder risk; career; career development; cognitive function; cognitive testing; cohort; cost; cost effective; distinguished professor; epidemiology study; gray matter; imaging biomarker; in vivo imaging; innovation; insight; men; middle age; mild cognitive impairment; modifiable risk; multidisciplinary; neurofilament; neuroimaging; neuropathology; neurotrophic factor; novel; population based; preservation; prevent; professor; programs; prospective; relating to nervous system; research and development; sex; single molecule; skills; tau Proteins; vascular cognitive impairment and dementia

ABSTRACT This is a NIH Pathway to Independence Award (K99/R00) application intended to promote the career of Dr. Priya Palta, PhD, a postdoctoral fellow at the University of North Carolina at Chapel Hill, to a path of independent research. Dr. Palta is a trained epidemiologist with a multidisciplinary record of research in the epidemiology of cardiovascular disease (CVD), aging, and CVD risk factors for cognitive decline and dementia. Her goal is to build on these skills through focused training in neuroscience to become an independent scientist at the interface of neuroscience and population sciences, for innovative work on modifiable targets that influence pathways associated with age-related cognitive decline. The topical areas of the proposed training and subsequent research are physical activity, age-related cognitive decline, neuroimaging, and neurotrophic factors reported to link physical activity with increased neuroplasticity. K99 Career development aim: Obtain transdisciplinary competencies in the biochemical and neural pathways that underlie cognitive function, including neurotrophic biomarkers and neuroimaging modalities through a didactic and experiential curriculum complemented by a novel prospective population-based study. These activities will be supervised by lead mentor Dr. Gerardo Heiss, MD PhD, Kenan Distinguished Professor of Epidemiology and co-mentors Dr. Kelly Evenson, PhD, Research Professor of Epidemiology, and Dr. Thomas Mosley, PhD, Professor of Medicine (Geriatrics) and Neurology. A team of collaborators with complementary expertise will supplement Dr. Palta's training in specific areas. The team of mentors and collaborators is fully committed to assisting Dr. Palta reach her research training and career development goals and to ensure her successful transition to independent researcher. Post-mentored R00 phase: Dr. Palta will apply the K99 competencies to develop an innovative R00 project nested in the cohort of the ongoing Atherosclerosis Risk in Communities (ARIC) Study. For this, physical activity over 23 years and neurotrophic markers (BDNF and IGF-1) measured on the ARIC participants will be related to repeat cognitive assessments, gray matter hippocampal volumes, and adjudicated mild cognitive impairment (MCI) and Alzheimer's disease (AD). Anticipated results: Through this Pathway to Independence Award, Dr. Palta will acquire (1) in-depth multidisciplinary training in the measurement, analysis and interpretation of (a) neurotrophic biomarkers and (b) neuroimaging outcomes for their application in population-based studies and (2) apply these new competencies to an innovative research question on the biochemical and neural links between physical activity and neurocognitive outcomes. This proposal will contribute novel science in the (1) critical assessment of the role of midlife physical activity in delaying cognitive impairment, (2) on the population distribution of BDNF and IGF-1 and its associations with physical activity and neurocognitive outcomes, and (3) targets for community-based lifestyle and physical activity programs to impact cognitive aging.

抽象的 这是 NIH 独立之路奖 (K99/R00) 申请，旨在促进 Dr. 的职业生涯。 Priya Palta 博士是北卡罗来纳大学教堂山分校的博士后研究员，她走上了一条 独立研究。 Palta 博士是一位训练有素的流行病学家，在该领域拥有多学科研究记录。 心血管疾病 (CVD) 的流行病学、衰老以及认知能力下降和痴呆的 CVD 危险因素。 她的目标是通过神经科学方面的集中培训来增强这些技能，成为一名独立的人 神经科学和人口科学交叉领域的科学家，在可修改目标方面进行创新工作 影响与年龄相关的认知衰退相关的途径。拟议的主题领域 培训和后续研究包括体力活动、与年龄相关的认知能力下降、神经影像学和 据报道，神经营养因子将体力活动与神经可塑性增强联系起来。 K99 职业发展 目标：获得认知基础的生化和神经通路的跨学科能力 功能，包括通过教学和体验的神经营养生物标志物和神经影像模式 课程辅以一项新颖的基于人群的前瞻性研究。这些活动将受到监督 由首席导师 Gerardo Heiss 博士（医学博士、凯南流行病学杰出教授）和共同导师撰写 凯利·埃文森 (Kelly Evenson) 博士、流行病学研究教授和托马斯·莫斯利 (Thomas Mosley) 博士、流行病学教授 医学（老年病学）和神经病学。具有互补专业知识的合作者团队将补充博士的工作。 帕尔塔在特定领域的培训。导师和合作者团队完全致力于协助博士。 Palta 实现了她的研究培训和职业发展目标，并确保她成功过渡到 独立研究员。指导后 R00 阶段：Palta 博士将应用 K99 能力来开发 创新的 R00 项目属于正在进行的社区动脉粥样硬化风险 (ARIC) 研究的队列。 为此，需要在 ARIC 上测量 23 年以上的体力活动和神经营养标记物（BDNF 和 IGF-1） 参与者将与重复认知评估、灰质海马体积以及 判定为轻度认知障碍（MCI）和阿尔茨海默病（AD）。预期结果：通过此 获得独立之路奖后，Palta 博士将获得 (1) 深入的多学科培训 (a) 神经营养生物标志物和 (b) 神经影像结果的测量、分析和解释 它们在基于人群的研究中的应用，以及（2）将这些新能力应用于创新研究 关于身体活动和神经认知结果之间的生化和神经联系的问题。这 该提案将在以下方面贡献新颖的科学：（1）对中年体力活动在以下方面的作用进行批判性评估： 延迟认知障碍，(2) BDNF 和 IGF-1 的群体分布及其与 身体活动和神经认知结果，以及（3）基于社区的生活方式和身体健康的目标 影响认知老化的活动计划。

项目成果

Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.

按种族和性别划分的美国亚人群中年至晚年的休闲时间体力活动量、强度和持续时间。

• 发表时间: 2020-03-13
• 作者: Kats, Dmitry;Evenson, Kelly R;Zeng, Donglin;Avery, Christy L;Palta, Priya;Kritchevsky, Stephen B;Heiss, Gerardo
• 通讯作者: Heiss, Gerardo