Arsenic and other co-metals in the San Carlos Apache drinking water

圣卡洛斯阿帕奇饮用水中的砷和其他共金属

基本信息

批准号：
10302159
负责人：
Christine Samuel-Nakamura
金额：
$ 15.7万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10302159
关键词：
Address Age Air American Indians Apache Area Arizona Arsenic Asbestos Assessment tool Behavioral Sciences Biological Models Bladder Breast Cadmium Carcinogens Cardiovascular Diseases Chronic Clinical Sciences Communities Consumption Copper County Data Diabetes Mellitus Dose Education Elements Enrollment Environment Excess Mortality Exposure to Female Breast Carcinoma Food Foundations Future General Population Geographic Information Systems Geological Survey Geology Goals Grant Health Health Resources Health Services Health care facility Healthcare Incidence Ingestion International Agency for Research on Cancer International Classification of Disease Codes Intervention Intervention Studies Investigation Kidney Knowledge Lead Leadership Link Literature Logistic Regressions Lung Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Malignant neoplasm of urinary bladder Maps Medical Metal exposure Metals Mining Mission Monitor Movement Nitrates Non-accidental Odds Ratio Outcome Pilot Projects Policy Developments Population Prevention Privatization Prostate Recording of previous events Records Renal carcinoma Reporting Research Personnel Reservations Resource Allocation Resources Risk Rural Community Scientific Advances and Accomplishments Scientist Screening for cancer Silver Skin Skin Cancer Social Sciences Soil Source Statutes and Laws Surveillance Program System Testing Time Training Tribes Underserved Population United States Environmental Protection Agency United States Indian Health Service Uranium Water Water Pollutants Work anthropogenesis base cancer diagnosis cancer health disparity case control design drinking water health record high risk improved improved outcome intertribal malignant breast neoplasm melanoma mortality neoplasm registry novel poor communities reproductive outcome response sex suburban communities tribal health tribal healthcare tribal leader tribal member underserved community urinary water quality well water

项目摘要

ABSTRACT. The broad, long-term objectives of this K01 project are to improve the health of Apache American Indians through a study that examines the association between cancer (CA) outcomes and Arsenic (As), co- metals, and nitrate on the San Carlos Apache (SCA) reservation in Arizona. The study setting has an extensive history of hard rock mining since the early 1900s when uranium (U), copper, silver, and asbestos were extracted. Anthropogenic causes and naturally occurring elements can cause movement of As and co-metals into the environment and may result in adverse health effects. Arsenic is a known carcinogen and is associated with diabetes, adverse reproductive outcomes, and cardiovascular disease. A main goal of this pilot study is to develop and implement an exposure assessment tool (EAT) to study cancers and to use in the future to examine the association between exposures and multiple adverse health outcomes. The specific aims are to: 1) characterize historical water data by time and recorded As, Cd, Pb, U, and nitrate concentration levels from 1981-2021, 2) examine the association between chronically elevated As, Cd, Pb, U, and nitrate in water and CA outcomes (bladder, kidney, prostate, lung, breast, and skin), 3) analyze and apply a Geographic Information System (GIS) model to map high-risk (As, Cd, Pb, U, nitrate) areas based on this EAT, and 4) provide study findings to tribal members and leaders. A retrospective pair matched case-control (N = 160) design will be employed. Decades of As, Cd, Pb, U, and nitrates concentration levels recorded by the US Environmental Protection Agency (EPA), tribal EPA, and US Geological Survey from areas known to have elevated As, co-metal and nitrate concentration levels will be collected. Local tribal health/Indian Health Service (IHS) records will be examined for CA diagnoses and mortality (using ICD codes) reported by the IHS, tribal health, private health records, state CA registries, and mortality records of the past 10 years. Study controls will be selected from SCA enrollment data and matched to cases by sex and age. Odds Ratios will be reported using logistic regression to determine associations between exposure risk and outcomes. A dose response between chronic As, Cd, Pb, U, and nitrate water ingestion and reported cancers are anticipated. This is the first local study to retrospectively examine water contaminant levels in relation to multiple CA outcomes. The data will form the foundation for an R01 intervention study to educate, screen, and identify risks for adverse health outcomes among residents. Findings will be disseminated to tribal members and leaders, healthcare facilities, and the general population. This study has the potential to augment prevention efforts, intervention, education, monitoring/surveillance, and can support policy development and legislation. The project will reach a nationally underserved population in the biomedical, social, behavioral, and clinical sciences and is in alignment with training diverse scientists in fields per the NCI grant purpose and mission. The study addresses CA disparities in an underserved community while advancing scientific knowledge.

抽象的。 K01 项目的广泛、长期目标是改善 Apache American 的健康状况印度人通过一项研究检查癌症 (CA) 结果与砷 (As) 之间的关联，亚利桑那州圣卡洛斯阿帕奇 (SCA) 保留地的金属和硝酸盐。研究环境广泛自 1900 年代初以来硬岩开采的历史，当时铀 (U)、铜、银和石棉提取的。人为原因和自然发生的元素可引起砷和共金属的移动进入环境并可能对健康造成不利影响。砷是一种已知的致癌物质，与与糖尿病、不良生殖后果和心血管疾病有关。这项试点研究的主要目标是开发并实施暴露评估工具（EAT）来研究癌症并在未来使用检查暴露与多种不良健康结果之间的关联。具体目标是： 1) 按时间描述历史水数据并记录 As、Cd、Pb、U 和硝酸盐浓度水平 1981-2021, 2) 检查水中砷、镉、铅、铀和硝酸盐长期升高之间的关联 CA 结果（膀胱、肾脏、前列腺、肺、乳房和皮肤），3) 分析并应用地理信息系统 (GIS) 模型，用于根据此 EAT 绘制高风险（As、Cd、Pb、U、硝酸盐）区域图，以及 4) 向部落成员和领导人提供研究结果。回顾性配对病例对照（N = 160）将采用设计。美国记录的几十年来的砷、镉、铅、铀和硝酸盐浓度水平环境保护署 (EPA)、部落 EPA 和美国地质调查局（来自已知有过污染的地区）将收集浓度升高的砷、共金属和硝酸盐。当地部落健康/印第安健康将检查服务 (IHS) 记录以了解 IHS 报告的 CA 诊断和死亡率（使用 ICD 代码），部落健康、私人健康记录、州 CA 登记处以及过去 10 年的死亡率记录。学习对照将从 SCA 登记数据中选择，并按性别和年龄与病例进行匹配。优势比将为报告使用逻辑回归来确定暴露风险和结果之间的关联。一个剂量预计长期摄入砷、镉、铅、铀和硝酸盐水与报告的癌症之间存在反应。这是第一项回顾性研究与多个 CA 相关的水污染物水平的本地研究结果。这些数据将构成 R01 干预研究的基础，以教育、筛查和识别风险居民的不良健康结果。调查结果将分发给部落成员和领导人，医疗机构和普通民众。这项研究有可能加强预防工作，干预、教育、监测/监督，并可以支持政策制定和立法。这项目将惠及全国生物医学、社会、行为和临床方面服务不足的人群科学，并符合根据 NCI 拨款目的和使命在各个领域培训不同的科学家。该研究解决了服务不足的社区中 CA 的差异，同时推进了科学知识。