Neurodevelopment

神经发育

基本信息

批准号：
10302206
负责人：
Deirdre C Lyons
金额：
$ 15.58万
依托单位：
UNIVERSITY OF MASSACHUSETTS AMHERST
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10302206
关键词：
ATAC-seq Address Adolescent Adult Animal Model Animals Anterior Apical Atlases Automobile Driving Biological Assay Biological Metamorphosis Brain Caenorhabditis elegans Calcium Cell Lineage Cells Chimeric Proteins Chromatin Cnidaria Collaborations Crustacea DNA Data Data Science Core Data Set Databases Development Drosophila genus Ectoderm Embryo Embryonic Development Esophagus Gene Expression Gene Transfer Techniques Genes Genetic Genome Genomics Germ Lines Goals Head Heart Intestines Investigation Knowledge Larva Left Maps Methods Modeling Molecular Mus Muscle Nervous system structure Neuraxis Neurons Neurosciences Nucleic Acid Regulatory Sequences Nucleic Acids Organ Organism Outcome Peripheral Nerves Peripheral Nervous System Preparation Process Regulator Genes Regulatory Element Reporter Resolution Series Structure Transcriptional Regulation Transgenes Transgenic Animals Transgenic Organisms Transposase Urochordata Work Zebrafish base blastomere structure cell type experimental study foot genome-wide insight molecular modeling nervous system development network models neurodevelopment neurogenesis novel programs relating to nervous system sensor single-cell RNA sequencing tool transcriptome sequencing transgene expression visual processing

项目摘要

PROJECT SUMMARY / ABSTRACT – Project 4. Neurodevelopment The goal of this Project is to provide a developmental perspective to the overall goals of the Berghia Brain Project to understand the implementation of somatotopic, olfactory, and visual processing. These goals will be aided by investigation into the origin of the neurons involved. Work on the developmental origin of identified neurons essentially stopped forty years ago and this project fills that gap in our knowledge. Project 4 will identify the embryonic cells that give rise to neurons in the central and peripheral nervous systems. It will identify the genes that make these cells unique, and use that information to identify the regulatory information necessary to drive fluorescent fusion proteins in specific neurons. These insights will expand our understanding of neurogenesis to molluscs, a diverse clad of organisms that has been relatively understudied, and thus holds potential for uncovering novel cellular and molecular mechanisms for nervous system development.

项目摘要/摘要 – 项目 4. 神经发育该项目的目标是为 Berghia 大脑项目的总体目标提供发展视角了解躯体、嗅觉和视觉处理的实现这些目标将得到帮助。研究相关神经元的起源研究已识别神经元的发育起源。四十年前基本上就停止了，这个项目填补了我们的知识空白，项目 4 将确定这一点。它将识别产生中枢和周围神经系统神经元的胚胎细胞。使这些细胞独一无二，并使用该信息来识别驱动所需的监管信息这些见解将扩大我们对神经发生的理解。对于软体动物来说，软体动物是一种多样化的生物体，人们对它的研究相对较少，因此具有潜在的揭示神经系统发育的新细胞和分子机制。