Nutritional Quality of Breast Milk after 6 Months Postpartum in India

印度产后 6 个月母乳的营养质量

基本信息

批准号：
10303840
负责人：
Saurabh Mehta
金额：
$ 7.85万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-17 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10303840
关键词：
Academy Agriculture American Archives Biological Biological Markers Breast Feeding Carotenoids Child Child Nutrition Choline Clinical Clinical Trials Complement Complementary Feeding Consumption Data Development Dietary Intervention Dietary intake Exclusive Breastfeeding Fatty Acids Food Foundations Funding Future Goals Growth Guidelines Health Human Milk India Infant Intake Intention Intervention Knowledge Life Macronutrients Nutrition Malnutrition Methods Milk Modeling Morbidity - disease rate Mothers Nutrient Nutritional Nutritional status Parents Participant Pediatrics Pennisetum Population Postpartum Period Randomized Randomized Controlled Trials Reporting Research Resources Risk Rural Sampling Sweet Potato Time Vitamin A Wheat Woman Work World Health Organization Zinc adverse event risk base comparative efficacy cost efficient dietary dietary guidelines evidence base feeding follow-up immune function improved insight iron deficiency mother nutrition primary outcome response secondary analysis statistics study population trial comparing

项目摘要

PROJECT SUMMARY Breast milk is a critical component of infant and young child nutrition in the first 1,000 days of life and has well- established benefits for mother and child. The complementary feeding period involves the transition from exclusive breastfeeding to partial/continued breastfeeding along with gradual introduction of complementary foods. During this time, the child is at increased risk for dietary and growth deficits, which are often due to poor complementary feeding practices and lack of evidence regarding maternal breast milk composition. Furthermore, the extent to which breast milk composition and quality can be modulated through maternal dietary interventions remains unclear. Interventions to date have mainly focused on breast milk composition during the first six months postpartum or analyzed single nutrients or nutrient groups. A comprehensive assessment of micro- and macronutrient contents in breast milk after 6 months postpartum, while breastfeeding is still ongoing, and its longitudinal change in response to a dietary intervention has, to our knowledge, never been conducted. To accomplish this, we will study breast milk samples from a subset of breastfeeding mothers who are participating in a randomized controlled feeding trial comparing the efficacy of biofortified versus conventional crop consumption in mothers and children in South India. We have collected and archived breast milk samples at five different timepoints across nine months during the child’s complementary feeding period. The objective of the proposed research is to increase our understanding of breast milk quality during the complementary feeding period. We aim to close the current evidence gap with two Specific Aims. (1) We will determine and describe the micro- and macronutrient composition of breast milk after 6 months postpartum; (2) We will also determine the impact of a nutrition intervention on breast milk composition with longitudinal samples collected during follow-up in a randomized controlled feeding trial. The proposed analysis will provide unique insights into the relationship between maternal nutritional status and breast milk composition in the complementary feeding period. Through this proposed research we aim to lay the foundation for future studies aiming to enhance breast milk quality to both improve the nutritional status of and lower the associated risk for adverse events and morbidity in children. 1

项目概要母乳是婴幼儿出生后 1,000 天内营养的重要组成部分，具有良好的添加辅食对母亲和儿童的既定益处包括从婴儿到婴儿的过渡期。从纯母乳喂养到部分/持续母乳喂养，并逐步引入辅食在此期间，儿童出现饮食和生长缺陷的风险增加，这通常是由于贫困造成的。此外，补充喂养方法和缺乏有关母乳成分的证据。通过母亲饮食干预可以调节母乳成分和质量的程度迄今为止，干预措施主要集中在前六个月的母乳成分上。产后或分析单一营养素或营养素组的综合评估。产后 6 个月后，母乳喂养仍在进行时，母乳中常量营养素的含量，及其据我们所知，从未进行过针对饮食干预的纵向变化。为了实现这一目标，我们将研究一部分母乳喂养母亲的母乳样本，这些母亲是参与一项随机对照喂养试验，比较生物强化与传统的功效我们收集并存档了印度南部母亲和儿童的农作物消费情况。在孩子的九个月的五个不同时间点添加辅食的目标。拟议的研究旨在增加我们对辅食喂养期间母乳质量的了解我们的目标是通过两个具体目标来缩小当前的证据差距（1）我们将确定并描述。产后 6 个月后母乳的微量和常量营养成分 (2) 我们还将确定通过随访期间收集的纵向样本，了解营养干预对母乳成分的影响在一项随机对照喂养试验中，拟议的分析将为这种关系提供独特的见解。辅食喂养期间母亲营养状况与母乳成分之间的关系。这项拟议的研究旨在为未来旨在增强母乳的研究奠定基础改善营养状况并降低不良事件和发病率的相关风险的质量在儿童中。 1