1/2 CSUF/UCI-CFCCC Cancer Health Disparities Research Program (CHERP)

1/2 CSUF/UCI-CFCCC 癌症健康差异研究计划 (CHERP)

基本信息

批准号：
10302802
负责人：
MARCELO E TOLMASKY
金额：
$ 37.57万
依托单位：
CALIFORNIA STATE UNIVERSITY FULLERTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10302802
关键词：
Address Administrator Advisory Committees Advocate African American Applications Grants Asians Basic Science Biological Sciences Biotechnology Breast Cancer Risk Factor California Cancer Center Cancer Research Project Collaborations Communities Comprehensive Cancer Center County DNA sequencing Data Development Education Education and Outreach Educational Curriculum Environment Epidemiology Ethnic group Evaluation Faculty Family Fostering Funding Future Genetic Genomics Goals Grant Institution Institutionalization Joints Knowledge Length Lesbian Gay Bisexual Transgender Queer Low income Malignant Neoplasms Malignant neoplasm of ovary Oranges Pattern Pilot Projects Population Preparation Principal Investigator Recommendation Records Research Research Personnel Research Project Grants Research Training Sampling Scientist Seasons Students System Talents Teacher Professional Development Training Training Activity Training Programs Training and Education Underrepresented Students Underserved Population United States National Institutes of Health Universities anticancer research base cancer health disparity cancer research center director community based participatory research community engagement disability education research epidemiology study ethnic diversity experience graduate student health disparity health equity innovation institutional capacity lipidomics meetings member minority health mortality outreach professor programs student training transcriptome sequencing transcriptomics triple-negative invasive breast carcinoma tumor undergraduate student underrepresented minority student

项目摘要

CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP) Overall Component: Abstract California State University, Fullerton (CSUF) is an institution serving underserved populations and underrepresented students (ISUPS), and the University of California, Irvine Chao Family Comprehensive Cancer Center (UCI-CFCCC) is an NCI-designated comprehensive cancer center. Together, we plan to establish a collaborative partnership to develop pilot research projects between faculty members at CSUF and UCI-CFCCC that will generate preliminary data for R01 or other competitively funded grant applications, and educate undergraduates (at CSUF) and master's students (at CSUF and UCI) in cancer health disparities research. The Partnership plans to fund five pilot projects, and educate a total of 38 students during the length of the proposed grant period. The overall specific aims of this new cancer-specific partnership are to: plan, implement and evaluate a highly integrated and interactive cancer health disparities partnership between CSUF and UCI- CFCCC; conduct pilot cancer health disparities research projects involving at least one investigator at each institution that advance knowledge regarding cancer health disparities, leading to the submission of competitive grant applications by NIH/NCI and other federal/non-federal agencies; and provide cancer research education to underrepresented undergraduate and graduate students to increase their understanding of cancer health disparities, leading to a larger pool of highly talented future scientists from diverse backgrounds. To accomplish this we will undertake a set of activities organized under four components. The Administrative Core will be responsible for the overall administrative and fiscal aspects of all P20 activities, and will include the Executive Committee and Internal Advisory Committee. Activities will be implemented in three stages: initial planning, implementation, and evaluation. The evaluation effort will be spearheaded by an external evaluator with expertise in multi-component center reviews. The two pilot research projects each focus on a cancer health disparity: the first is a basic science study that will conduct lipidomic profiling, and DNA and RNA sequencing of tumor/NAT paired samples to optimize sample preparation and detect genetic/genomic and transcriptomic differences that are related to African American triple negative breast cancer risk. The second is an epidemiological study that will examine Asian sub-ethnic group differences in ovarian cancer mortality and treatment patterns. The long term goals of this collaborative partnership are to diversity the cancer research workforce and ultimately increase our scientific impact to address the cancer health disparity needs in Orange County, California.

CSUF/UCI-CFCCC 癌症健康公平研究合作伙伴关系 (CHERP) 整体组成部分：摘要加州州立大学富勒顿分校 (CSUF) 是一所为服务不足的人群和代表性不足的学生 (ISUPS) 和加州大学欧文分校 Chao 家庭综合癌症中心中心（UCI-CFCCC）是NCI指定的综合性癌症中心。我们计划共同建立一个 CSUF 和 UCI-CFCCC 教师之间建立合作伙伴关系，开发试点研究项目将为 R01 或其他竞争性资助的拨款申请生成初步数据，并教育本科生（CSUF）和硕士生（CSUF 和 UCI）从事癌症健康差异研究。这合作伙伴计划资助五个试点项目，并在拟议的项目期间总共教育 38 名学生授予期。这一新的针对癌症的合作伙伴关系的总体具体目标是：规划、实施和评估 CSUF 和 UCI 之间高度集成和互动的癌症健康差异伙伴关系中国交通运输委员会；开展试点癌症健康差异研究项目，每个项目至少涉及一名研究人员促进有关癌症健康差异的知识的机构，从而导致提交竞争性的 NIH/NCI 和其他联邦/非联邦机构的拨款申请；并提供癌症研究教育为代表性不足的本科生和研究生提供帮助，以增加他们对癌症健康的了解差异，导致来自不同背景的更多才华横溢的未来科学家。为了实现这一目标，我们将开展一系列由四个部分组成的活动。行政部门核心将负责P20所有活动的总体行政和财务方面，并将包括执行委员会和内部咨询委员会。活动将分三个阶段实施：初始阶段规划、实施和评估。评估工作将由外部评估员牵头具有多组件中心审查方面的专业知识。这两个试点研究项目各自侧重于癌症健康差异：第一个是基础科学研究，将进行脂质组学分析以及 DNA 和 RNA 测序肿瘤/NAT 配对样品以优化样品制备并检测遗传/基因组和转录组与非裔美国人三阴性乳腺癌风险相关的差异。第二个是一个流行病学研究将探讨亚洲亚族群在卵巢癌死亡率和死亡率方面的差异治疗模式。这种合作伙伴关系的长期目标是使癌症研究多样化劳动力并最终提高我们的科学影响力，以解决奥兰治的癌症健康差异需求县，加利福尼亚州。