NEW DIRECTIONS POLYMER MEMBRANE BASED ION SENSORS

基于聚合物膜的离子传感器的新方向

• 批准号: 2175301
• 负责人: MARK E MEYERHOFF
• 金额: $ 11.93万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2175301
• 关键词: amine oxidoreductase; artificial membranes; biomedical equipment development; biosensor device; blood chemistry; clinical chemistry; dogs; electrodes; metalloporphyrins; monitoring device; nitric oxide synthase; polymers; potentiometry; respiratory gas level; silicone rubber

The further design, study, and bioanalytical applications of novel polymer membrane based chemical sensors are proposed. This research will build upon the recent successes of this program in developing a variety of new ion/gas chemical sensors that are useful for the direct detection of biomedically important species in complex samples, including whole blood. Efforts during the next phase of this project will include both fundamental and applied studies, with an emphasis on pursuing completely new concepts/strategies, both with respect the type analyte ions that may be detected via polymer membrane technology, and the chemical methods used to achieve desired ion selectively. A major thrust of the program will be to identify and study highly selective membrane chemistries for in situ sensing of anionic species. Specific new goals include: 1) examining the response mechanism and potential bioanalytical applications of a novel polymer membrane electrode that exhibits unique and clinically useful potentiometric response to the anticoagulant heparin, a macromolecular polyanion (both porcine and beef types); 2) studying the response properties/mechanisms of metalloporphyrin base anion-selective membranes with focus on determining the theoretical and practical advantages of adding fixed lipophilic anionic sites to enhance anion selectivity and on developing a Co(III)-porphyrin or corrin based nitrite selective sensors for monitoring cellular activity of nitric oxide synthase; and 3) assessing the utility of new molecular/ion imprinting techniques to prepare polymer films (silicone rubber) that may exhibit enhanced potentiometric selectivity to biologically important anions, especially carbonate, phosphates, low molecular weight heparin fragments, etc. In addition to these new directions, ongoing efforts to use various surface modification methods to render polymer membrane types gas and ion-selective catheter type sensors more blood compatible will be extended into this next phase of support. It is anticipated that this research program will continue to provide the biomedical community with an array of new/or improved chemical sensors as well the basic knowledge and chemistry that will be required to develop additional sensors, both electrochemical and optical, in the future.

新型的进一步设计，研究和生物分析应用 提出了基于聚合物膜的化学传感器。 这项研究会 基于该计划在开发多样性方面取得的成功 新的离子/气体化学传感器，可用于直接检测 复杂样品中的生物医学重要物种的物种，包括整个 血。 在此项目的下一阶段的努力将包括 基本和应用研究，重点是完全追求 新的概念/策略，既尊重可能的类型分析物 通过聚合物膜技术和化学方法检测 用于选择性地实现所需的离子。 该计划的重大推力 将识别和研究高度选择性的膜化学成分 原位感测阴离子物种。 特定的新目标包括：1） 检查响应机制和潜在的生物分析应用 一种新型聚合物膜电极，该电极具有独特的和临床 对抗凝肝素的有用电位计量反应，A 大分子聚会（猪和牛肉类型）； 2）研究 金属卟啉基碱基选择性的响应特性/机制 膜重点是确定理论和实用性 添加固定亲脂性阴离子位点以增强阴离子的优点 选择性和开发CO（III） - 卟啉或基于Corrin的亚硝酸盐 用于监测一氧化氮细胞活性的选择性传感器 合酶； 3）评估新分子/离子烙印的效用 准备可能表现出的聚合物膜（硅橡胶）的技术 增强对生物学上重要阴离子的电位选择性， 特别是碳酸盐，磷酸盐，低分子量肝素碎片， 除了这些新的方向外，持续使用各种努力 表面修饰方法使聚合物膜类型的气体和 离子选择性导管型传感器更多的血液兼容 扩展到下一阶段的支持。 预计这是 研究计划将继续为生物医学界提供 一系列新/改进的化学传感器以及基本知识 以及开发其他传感器所需的化学反应 将来，电化学和光学。