Advancing the science of neurocognitive physiology in adolescents living with HIV

推进青少年艾滋病毒感染者的神经认知生理学科学

基本信息

批准号：
10299869
负责人：
Megan Song McHenry
金额：
$ 16.94万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10299869
关键词：
17 year old Adolescent Adverse effects Africa Africa South of the Sahara African Auditory Biological Assay Brain Child Childhood Clinical Research Cognition Cognitive Cognitive deficits Collaborations Communities Complex Consult Data Degree program Educational workshop Evaluation Event Event-Related Potentials Fostering Functional Magnetic Resonance Imaging Funding Geographic Locations Goals HIV HIV Infections Health Human Impaired cognition Impairment Individual Infrastructure Intervention Kenya Knowledge Lead Life Liquid substance Malnutrition Master&apos s Degree Measures Mediating Medical Medical History Medical Psychology Mentors Mentorship Methodology Methods Mission Modeling Motor Neurobiology Neurocognition Neurocognitive Neurocognitive Deficit Neuropsychology Neurosciences Neurotransmitters Outcome Perinatal Physiology Population Posture Predictive Factor Process Publishing Reporting Research Research Support Resources Risk Factors Science Sensory Series Signal Transduction Site Students Supervision Synapses System Teacher Professional Development Techniques Testing Time Training Training Programs United States National Institutes of Health Universities Viral Load result Visual Work Youth adverse outcome antiretroviral therapy cognitive function cohort cost effective disability experience eyeblink conditioning faculty support improved outcome indexing information processing motor learning nervous system disorder neurodevelopment neurophysiology peer perinatal HIV portability programs response sociodemographic factors sociodemographics symposium therapeutic target therapy adherence virtual

项目摘要

PROJECT SUMMARY Adolescents living with HIV (ALHIV) have been shown to experience neurocognitive impairment compared to their uninfected peers, but the underlying neurophysiology considered to be the fundamental building blocks of complex cognitive processing have not been rigorously studied within this population. Therefore, there is a crit- ical need for a comprehensive study of neurophysiology and cognitive function in ALHIV, especially in sub-Sa- haran Africa, which comes with unique health and socio-demographic risk factors that compound the adverse effects of HIV infection. The specific objectives of the proposed project is to: (1) determine the impact of HIV infection on neurophysiology and neurocognition in perinatally-infected adolescents and identify potential me- diating factors; and (2) build capacity for interdisciplinary neurophysiological research in sub-Saharan Africa by supporting intensive training for faculty development and tiered mentoring in neurophysiological methodologi- cal techniques. The central hypothesis is that ALHIV will show altered neurophysiology and impaired cognition compared to their unexposed peers. The rationale for this study is that evaluations utilizing event-related poten- tials (ERP) are uniquely suited determine which sensory and information processing stages are impaired and contribute to cognitive abnormalities in ALHIV. In Aim 1, we will determine the impact of HIV infection on neurophysiology and neurocognition in perinatally-infected adolescents and identify potential mediating socio- demographic and health/medical factors. To achieve this aim we will characterize ERP responses and their rela- tionship to cognitive function in ALHIV (14-17 years old) compared to uninfected adolescents (n=50/group) to develop a model to determine childhood factors predictive of poor neurophysiological and cognitive outcomes. Cognitive and sensory ERP paradigms, associative motor learning and motor coordination tasks, and a culturally adapted version of the NIH Toolbox Fluid Cognition tests will be administered within Aim 1. In Aim 2, we will build capacity for interdisciplinary neurophysiological research by supporting intensive training for faculty de- velopment and tiered mentoring in neurophysiological methodological techniques. Within this aim, we will sup- port the faculty and students within the Moi University’s training programs in performing neuropsychological work, for both clinical and research purposes. This will be done through a series of training workshops, monthly virtual seminars, and on-site supervision, which will culminate within a national symposium to foster neuro- physiological research collaboration across Kenya. The proposed work is significant because it will be the first comprehensive neurophysiological study of ALHIV in sub-Saharan Africa, and Moi University will be the only Kenyan academic center with sustainable capacity for research in neurophysiology. Funding this proposal would strengthen and promote national collaboration aimed at identifying mediating health and sociodemographic fac- tors for intervention and facilitating the identification of therapeutic targets to improve the outcomes of individ- uals across the African continent.

项目概要研究表明，与感染艾滋病毒的青少年 (ALHIV) 相比，青少年会出现神经认知障碍。他们未受感染的同伴，但潜在的神经生理学被认为是复杂的认知处理尚未在该人群中得到严格研究，因此存在一个关键问题。需要对 ALHIV 的神经生理学和认知功能进行全面研究，特别是在亚萨- 哈兰非洲，具有独特的健康和社会人口风险因素，加剧了不利因素拟议项目的具体目标是： (1) 确定 HIV 感染的影响。感染对围产期感染青少年神经生理学和神经认知的影响，并确定潜在的治疗方法影响因素；(2) 建设撒哈拉以南非洲地区的跨学科神经生理学研究能力支持教师发展的强化培训和神经生理学方法论的分层指导- 核心假设是 ALHIV 会表现出神经生理学改变和认知受损。与未暴露的同行相比，这项研究的基本原理是利用事件相关的潜力进行评估。 IALS (ERP) 特别适合确定哪些感觉和信息处理阶段受损，以及导致 ALHIV 认知异常的因素在目标 1 中，我们将确定 HIV 感染对认知异常的影响。围产期感染青少年的神经生理学和神经认知，并确定潜在的介导社会- 为了实现这一目标，我们将描述 ERP 响应及其相关性。与未感染青少年（n=50/组）相比，ALHIV（14-17 岁）对认知功能的影响开发一个模型来确定预测不良神经生理学和认知结果的童年因素。认知和感觉 ERP 范式、联想运动学习和运动协调任务以及文化 NIH 工具箱流体认知测试的改编版本将在目标 1 中进行。在目标 2 中，我们将通过支持教师的强化培训来建设跨学科神经生理学研究的能力在此目标下，我们将支持神经生理学方法技术的发展和分层指导。将教职员工和学生纳入莫伊大学的神经心理学培训项目中工作，用于临床和研究目的，这将通过每月一系列的培训研讨会来完成。虚拟研讨会和现场监督，最终将在一次全国研讨会上达到高潮，以促进神经肯尼亚各地的生理研究合作非常重要，因为这将是第一个。莫伊大学将是撒哈拉以南非洲地区唯一对 ALHIV 进行全面神经生理学研究的大学具有可持续神经生理学研究能力的肯尼亚学术中心将资助该提案。加强和促进旨在确定调节健康和社会人口因素的国家合作干预和促进治疗目标的确定，以改善个体的结果整个非洲大陆的情况。