Duke Claude D. Pepper Older Americans Independence Center

克劳德·D·佩珀公爵美国老年人独立中心

• 批准号: 10291436
• 负责人: Kenneth E Schmader
• 金额: $ 131.47万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10291436
• 关键词: 2019-nCoV; Accelerometer; Achievement; Address; Adult; Adverse effects; Aging; American; Biological; Biometry; Caliber; Capsicum; Clinical; Clinical Research; Collaborations; Communities; Counseling; Data; Data Science; Development; Educational Curriculum; Educational workshop; Elderly; Electronic Health Record; Event; Feedback; Financial Support; Foundations; Funding; Geriatrics; Goals; Grant; Growth; Health; Hip Fractures; Inflammatory; Interdisciplinary Study; Intervention; Knowledge; Lead; Leadership; Longevity; Maintenance; Measurement; Measures; Mentors; Metabolic; Methodology; Methods; MicroRNAs; Modeling; Molecular; Molecular Profiling; Molecular Target; Operative Surgical Procedures; Outcome; Pathway interactions; Persons; Phenotype; Physical Function; Physical activity; Physiological; Pilot Projects; Positioning Attribute; Process; Recovery; Research; Research Personnel; Research Support; Research Training; Resources; Science; Scientific Advances and Accomplishments; Secure; Systems Analysis; Talents; Techniques; Testing; Training; Translational Research; Work; base; career development; circulating microRNA; dashboard; data integration; design; education research; experience; extracellular vesicles; health care disparity; health data; improved; innovation; insight; multidisciplinary; next generation; novel; peer support; programs; psychosocial; research and development; research study; resilience; response; restoration; sensor; stressor; success; synergism; targeted biomarker; therapy development; translational approach; working group

PROJECT SUMMARY – Overall Duke Claude D. Pepper Older Americans Independence Center (Duke OAIC) The Duke OAIC will provide scientific leadership, innovation, interdisciplinary research strategies, translational approaches, development of early-stage investigators and a collaborative spirit in its theme: to understand and optimize physiologic reserve and physical resilience in older adults. The specific aims are to advance knowledge of measures, mechanisms and analysis of reserve and resilience in older adults through an integrated research program; to develop and evaluate interventions that optimize reserve and resilience in older adults; to identify and develop the next generation of researchers who will become leaders in aging and geriatrics research related to the theme; and to support pilot studies that will progress to successful, more definitive research studies related to the Duke OAIC focus. The experienced Leadership and Administrative Core will direct OAIC activities. The Center supports a Research Education Component (REC), Pilot/Exploratory Studies Core (PESC) and three resource Cores: Molecular Measures, Health and Mobility Measures, and Analysis. The resource cores provide collaborative support to externally funded projects, developmental projects, REC Scholars and PESC pilot studies. In addition, the Molecular Measures Core will develop new molecular profiling and testing capabilities to evaluate resiliencies in the setting of stressors, including SARS-CoV2, and conduct systems analyses to identify biological pathways indicative of resilient phenotypes. The Health and Mobility Measures Core will identify gaps in reserve and resiliency measures at the person level, and develop and adapt innovative measurements for related outcomes; and build resiliency related data science capacity in collaboration with Duke’s Center for Actionable Health Data Science (Forge). The Analysis Core will develop and disseminate new biostatistical analytic methodologies to advance the study of reserve and resilience. The REC will deliver an aging research curriculum around promoting reserve and resilience, while providing multiple opportunities for feedback, networking, and peer support. The PESC will facilitate the highest caliber pilot studies related to our theme. The Duke OAIC will use innovative approaches to facilitate career development and research capabilities, including the Data Integration Working Group, “Pepper Shakers” Networking Events, Intervention Development for Elderly Adults (IDEA) workshops, National Research Mentoring Network Training Workshop, training workshops on physical function measurement and accelerometer analysis methods, Health Care Disparities Research Curriculum, Duke Pepper Center Study Dashboard and inclusion of community representatives in the pilot study selection process.

项目概要——总体 克劳德·D·佩珀杜克美国老年人独立中心 (Duke OAIC) 杜克大学 OAIC 将提供科学领导、创新、跨学科研究策略、转化 方法、早期研究人员的发展以及其主题的协作精神：理解和 优化老年人的生理储备和身体恢复能力。 通过对老年人的储备和复原力的措施、机制和分析的了解 综合研究计划；制定和评估优化储备和复原力的干预措施 老年人；识别和培养下一代研究人员，他们将成为老龄化和老龄化领域的领导者 与主题相关的老年病学研究；并支持试点研究，以取得成功，并取得更多成果 与杜克大学 OAIC 重点相关的权威研究是经验丰富的领导力和行政管理。 核心将指导 OAIC 的活动。该中心支持研究教育部分 (REC)、 试点/探索性研究核心 (PESC) 和三个资源核心：分子测量、健康和流动性 措施和分析。资源核心为外部资助的项目提供协作支持， 此外，分子测量核心还将开展开发项目、REC 学者和 PESC 试点研究。 开发新的分子分析和测试能力，以评估压力源环境下的弹性， 包括 SARS-CoV2，并进行系统分析，以确定指示弹性的生物途径 健康和流动性措施核心将确定储备和弹性措施的差距。 人员层面，制定和调整相关成果的创新衡量标准并建立弹性； 与杜克大学可行健康数据科学中心 (Forge) 合作，提升相关数据科学能力。 分析核心将开发和传播新的生物统计分析方法以推进研究 REC 将围绕促进储备和复原力提供老龄化研究课程。 弹性，同时提供多种反馈、网络和同行支持的机会。 杜克大学 OAIC 将使用创新方法来促进与我们的主题相关的最高水平的试点研究。 促进职业发展和研究能力，包括数据集成工作组， “胡椒瓶”网络活动、老年人干预发展 (IDEA) 研讨会、全国 研究指导网络培训班、身体机能测量培训班和 加速度计分析方法、医疗保健差异研究课程、杜克胡椒中心研究 仪表板以及将社区代表纳入试点研究选择过程。