Novel actions of neurosteroids on GABA (A) receptor trafficking

神经类固醇对 GABA (A) 受体运输的新作用

• 批准号: 10290964
• 负责人: Paul Andrew Davies
• 金额: $ 5.38万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10290964
• 关键词: Biochemistry; Classification; Communities; Development; Drug Industry; Electrophysiology (science); Exposure to; Fellowship; First Generation College Students; Funding; Future; GABA-A Receptor; Grant; Guam; Guamanian; Industry Collaboration; Learning; Mediating; Membrane; Mentorship; Methodology; Mosses; National Research Service Awards; Neurosciences; Neurosciences Research; Play; Publications; Regulation; Research Personnel; Role; Science; Supervision; Techniques; Training; Universities; Work; Writing; career; design; doctoral student; experimental study; graduate student; neurosteroids; novel; parent grant; pre-doctoral; rural area; skills; trafficking

Project Summary This application is for a diversity supplement to the R01 NS108378, entitled “Novel actions of neurosteroids on GABAAR trafficking” the PIs of which are Dr. Paul Davies and Dr. Stephen Moss at Tufts University. The diversity candidate is Noell, a beginning pre-doctoral student in the lab of Dr. Moss. Noell qualifies as a diversity candidate due to Guamanian classification and being a first-generation college graduate having grown up in Guam, a U.S. rural area. This supplement is to fund Noell’s first years in the lab for her to: 1) receive mentorship and training to advance in pursuit of a career in science, 2) work on preliminary experiments to submit a NRSA F31 fellowship. Dr. Stephen Moss has trained 20 graduate students, many whom are independent investigators, and has a well-respected track record of mentorship. Noell’s project is directly related to aims of the parent grant, which centers on the role that neurosteriods play in mediating the phospho-dependent regulation of GABAAR membrane trafficking. To do this, she will learn and apply techniques in electrophysiology and biochemistry. Overall, this project will give Noell broad exposure to contemporary methodologies used in “cutting edge” neuroscience research and prepare her for a career as an independent investigator. Other mentorship interactions between Noell and Dr. Moss funded by the supplement include building presentation skills, writing grants and scientific publications, ability to design experiments, exposure to the field through invited speakers, and interactions with pharmaceutical industry collaborators. The funding will importantly provide Noell with enrichment opportunities so she can connect with others in the broader neuroscience community. The diversity supplement will bridge Noell’s path towards a positive future in science and continue to build diversity at Tuft’s University. The activities in mentorship and enrichment made possible will be critical in Noell’s development as an independent investigator.

项目概要 本申请是对 R01 NS108378 的多样性补充，题为“Novel actions of GABAAR 贩运中的神经类固醇”，其 PI 是 Paul Davies 博士和 Stephen Moss 博士 塔夫茨大学的多样性候选人是诺埃尔，他是实验室的一名博士前学生。 由于关岛分类，诺埃尔博士有资格成为多元化候选人。 在美国农村地区关岛长大的第一代大学毕业生。 资助诺埃尔在实验室的第一年，让她能够：1）接受指导和培训，以取得进展 追求科学事业，2) 进行初步实验以提交 NRSA F31 Stephen Moss 博士培养了 20 名研究生，其中许多是独立的。 诺埃尔的项目是研究人员的直接指导，并且拥有备受尊敬的指导记录。 与家长资助的目标相关，其重点是神经类固醇在调解中发挥的作用 为此，她将学习 GABAAR 膜运输的磷酸依赖性调节。 总体而言，该项目将为诺尔提供电生理学和生物化学技术的应用。 广泛接触“尖端”神经科学研究中使用的当代方法 并为她成为一名独立调查员做好其他指导互动的准备。 诺尔和莫斯博士之间由增刊资助的项目包括培养演讲技巧、写作 赠款和科学出版物、设计实验的能力、通过以下方式接触该领域 受邀演讲者以及与制药行业合作者的互动。 重要的是为诺尔提供丰富的机会，这样她就可以与周围的其他人建立联系 更广泛的神经科学界的多样性补充将为诺尔的道路架起桥梁。 科学的积极未来，并继续在塔夫茨大学建立多样性。 指导和充实成为可能，这对于诺埃尔作为一个人的发展至关重要 独立调查员。