Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional)

Claude D. Pepper 美国老年人独立中心（P30 临床试验可选）

• 批准号: 10294028
• 负责人: Richard H Fortinsky
• 金额: $ 148.41万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294028
• 关键词: ARHGEF5 gene; Address; Affect; Aging; American; Area; Award; Behavior; Behavioral; Biological; Biological Markers; Capsicum; Caring; Clinical; Clinical Investigator; Clinical Trials; Cognition; Communities; Development; Discipline; Disease; Education; Effectiveness of Interventions; Elderly; Ensure; Environmental Risk Factor; Epidemiologist; Foundations; Funding; Genomic medicine; Geriatrics; Gerontology; Geroscience; Goals; Growth; Health; Heterogeneity; Home; Host Defense; Individual; Institution; Intervention; Knowledge; Leadership; Learning; Life; Medical Genetics; Mission; Outcome; Physiological; Pilot Projects; Research; Research Methodology; Research Personnel; Resources; Science; Scientist; Techniques; Testing; The Jackson Laboratory; Time; base; bench to bedside; career; clinical care; clinical translation; collaborative approach; community engagement; data resource; design; education research; experience; improved; innovation; insight; interdisciplinary approach; multidisciplinary; multiple chronic conditions; next generation; novel; novel strategies; population based; pre-clinical; pre-clinical research; precision medicine; preference; programs; ranpirnase; recruit; research study; social; social factors; synergism; tool; treatment response

PROJECT SUMMARY OVERALL This proposal seeks to establish the Claude D Pepper Older Americans Independence Center at UConn (UConn OAIC) with the overarching goal of developing clinical strategies for enhancing function and independence in older adults that are more precise, personalized, and effective. Our focus on Precision Gerontology has emerged through the collective experiences and insights of our multidisciplinary team of accomplished investigators in the UConn Center on Aging – all united by a shared commitment to improving the lives of older adults through research, education, and clinical care. Our emphasis on Precision Gerontology has been guided by three principles: 1. A growing heterogeneity or variability over time among individuals involving all aspects of aging that therefore necessitates a multidisciplinary team-based approach to aging research; 2. Increased heterogeneity or variability with aging in older adults’ responses to treatment, highlighting the need for better targeting; and 3. Recognition of a need to incorporate these considerations into the design and testing of novel geroscience-guided therapies. These objectives will be achieved by establishing a UConn OAIC through the coordinated activities of a Leadership and Administration Core (LAC), Recruitment and Community Engagement Core (RC1), Data Resource Core (RC2), Biomarker and Preclinical Research Core (RC3), Pilot and Exploratory Studies Core (PESC), and Research Education Component (REC). We will seek to address these goals through the following aims: Aim 1: To develop and refine new approaches to the study and clinical translation of Precision Gerontology. Aim 2: To develop and evaluate new research methods, techniques, and collaborative approaches required to advance the goals of Precision Gerontology. Aim 3: To identify, develop, and learn from experiences of the next generation of researchers poised to become leaders in geriatrics research related to the UConn OAIC focus. Aim 4: To select and support innovative pilot studies that show promise in helping to guide the design, funding, and completion of more definitive future research studies related to the UConn OAIC focus.

项目总体概要 该提案旨在建立克劳德·D·佩珀美国老年人独立中心 康涅狄格大学 (UConn OAIC) 的总体目标是制定临床策略 增强老年人的功能和独立性，使其更加精确、个性化和 我们对精准老年学的关注是通过集体经验而显现出来的。 康涅狄格大学中心的多学科研究团队的杰出研究人员的见解 老龄化——所有人都共同致力于通过以下方式改善老年人的生活： 研究、教育和临床护理。 我们对精准老年学的重视遵循三个原则： 1. 随着时间的推移，个体之间的异质性或变异性涉及衰老的各个方面， 因此需要采用基于多学科团队的方法来进行老龄化研究 2. 增加； 老年人对治疗的反应随着年龄的增长而存在异质性或变异性，突显了 需要更好的目标；以及 3. 认识到需要将这些考虑因素纳入 新型老年科学指导疗法的设计和测试。 这些目标将通过协调一致建立康涅狄格大学 OAIC 来实现。 领导和管理核心 (LAC)、招聘和社区的活动 参与核心 (RC1)、数据资源核心 (RC2)、生物标志物和临床前研究 核心（RC3）、试点和探索性研究核心（PESC）和研究教育部分 （记录）。 我们将通过以下目标寻求实现这些目标： 目标 1：开发和完善精度研究和临床转化的新方法 老年学。 目标 2：开发和评估新的研究方法、技术和协作 推进精准老年学目标所需的方法。 目标 3：识别、培养下一代研究人员并从中学习经验 准备成为与康涅狄格大学 OAIC 重点相关的老年病学研究的领导者。 目标 4：选择和支持有希望帮助指导的创新试点研究 设计、资助和完成与以下相关的更明确的未来研究 康涅狄格大学 OAIC 重点。