Neuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural Interfaces

Neuro-CROWN：用于 3D、低噪声神经接口的优化超灵活 CMOS 电极阵列

基本信息

批准号：
10294053
负责人：
Hui Fang
金额：
$ 69.09万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-27 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10294053
关键词：
3-Dimensional Amplifiers Animal Model Animals BRAIN initiative Brain Cerebral cortex Chronic Clinical Code Communities Device Designs Devices Educational workshop Electrodes Electronics Electrophysiology (science)Evaluation Feedback Funding Future Generations Gold Human Implant In Vitro Intelligence Measurement Measures Methods Microelectrodes Modeling Monitor Motor Neurons Neurosciences Neurosciences Research Noise Performance Polymers Population Prosthesis Real-Time Systems Research Research Personnel Resolution Resources Rodent Running Sampling Semiconductors Shapes Signal Transduction Silicon Site Societies Speech Surface System Techniques Technology Testing Thick Thinness Time Tissues Training Transistors Translating Update Wireless Technology base biomaterial compatibility brain machine interface clinical application cohort cost cost effective data streams denoising density design experimental study extracellular flexibility improved in vivo instrumentation irritation manufacturing process meetings metal oxide millimeter nervous system disorder neural circuit neural implant neuronal circuitry neuroprosthesis neurotransmission new technology next generation nonhuman primate novel program dissemination programs relating to nervous system scale up statistics system architecture tissue injury tool

项目摘要

Project Summary / Abstract The purpose of this project is to optimize circuit and system architectures of active electrode arrays which will provide low-noise, multiplexed acquisition of neural signals from thousands of electrodes. We will reduce noise by exploiting a novel current-sensing circuit approach and new multiplexing strategies, such as Code-Division Multiple Access (CDMA). We will also apply novel system level de-noising approaches using kriging. Finally, we will demonstrate our low noise, active arrays using a unique, ultra-flexible 3D neural interface paradigm: Neuro-CROWN: CMOS-based, ROlling-enabled, loW-noise Neuroelectronics. These electrode arrays include thousands of electrodes that can be used for both recording and stimulation, enabling studies that require recordings from multiple, large cortical regions in rodents and non-human primates (NHP) at cellular scale. The electrode arrays are extremely thin (<25 µm) and flexible, and are made in both non-penetrating and 3D penetrating configurations, of which the latter will be formed from a simple and unique rolling of 2D soft electrode array (ROSE) method. Amplifiers and multiplexers integrated directly into the electrode array, using commercially fabricated silicon transistors, intelligently combine signals inside the array so that recording from up to 4,096 electrodes is possible with fewer than 20 multiplexed external wire connections. The small number of interface wires facilitates long-term experiments in chronically-implanted, freely-behaving animals and eases future wireless integration. The electrode arrays will be manufactured in large quantities (3800 devices / run) using full wafers at X-fab. By leveraging a cost-effective manufacturing process, the raw materials cost of each electrode array will be ~$10, excluding post processing labor which will be supplied by this program. Our dissemination program will make device broadly available to a large cohort of end users. We have previously disseminated early-stage technology to ~10 labs are now scaling up to disseminate that technology to ~100 labs. Based on feedback we received during this dissemination effort, neural interfaces with high SNR and 3-dimensional measurement are critically important to neuroscience research, motivating this project. We will disseminate this new technology to at least 10 labs in this effort, solicited from the neuroscience community at large. We will solicit end user feedback through a workshop at the Society for Neuroscience (SfN) meeting and use this feedback to shape our device designs. This project seeks to enable BRAIN Initiative investigators and the broader neuroscience community to perform very large-scale recordings in animal models. Further, the research enabled by this technology will be able to be rapidly translated to humans in the future, through parallel, separately-funded efforts by our team to bring actively-multiplexed electrode arrays to human use.

项目概要/摘要该项目的目的是优化有源电极阵列的电路和系统架构，这将提供来自数千个电极的低噪声、多路复用神经信号采集。我们将减少噪声。通过利用新颖的电流感应电路方法和新的多路复用策略，例如码分我们还将使用克里格法应用新颖的系统级去噪方法。将使用独特、超灵活的 3D 神经接口范例展示我们的低噪声有源阵列： Neuro-CROWN：基于 CMOS、支持滚动、低噪声的神经电子学，这些电极阵列包括。数千个电极可用于记录和刺激，从而实现需要的研究来自啮齿动物和非人类灵长类动物（NHP）多个大皮质区域的细胞尺度记录。电极阵列极薄（<25 µm）且灵活，采用非穿透式和 3D 制成穿透结构，其中后者将由简单而独特的二维软电极滚动形成阵列（ROSE）方法将放大器和多路复用器直接集成到电极阵列中，使用商业化。制造的硅晶体管，智能地组合阵列内的信号，以便记录多达 4,096 电极可使用少于 20 个多路复用外部接线连接。接口数量少。电线有助于在长期植入、行为自由的动物中进行长期实验，并为未来提供便利电极阵列将使用完整的技术进行大批量生产（3800 个设备/运行）。通过利用具有成本效益的制造工艺，降低了每个电极的原材料成本。数组将约为 10 美元，不包括该程序提供的后处理工作。我们的传播计划将使设备广泛地提供给大量最终用户。之前已向约 10 个实验室传播了早期技术，现在正在扩大规模以传播该技术根据我们在传播工作中收到的反馈，神经接口具有高信噪比。和 3 维测量对于神经科学研究至关重要，推动了该项目的发展。将向神经科学界征集的至少 10 个实验室传播这项新技术我们将通过神经科学协会 (SfN) 会议上的研讨会征求最终用户的反馈。并利用这些反馈来塑造我们的设备设计。该项目旨在使 BRAIN Initiative 的研究人员和更广泛的神经科学界能够此外，该技术将实现大规模的动物模型记录。通过我们团队并行的、单独资助的努力，未来能够快速转化为人类主动多路复用电极阵列为人类带来了使用。