ALCOHOL AND AIDS-A MURINE MODEL

酒精和艾滋病——小鼠模型

基本信息

批准号：
3028478
负责人：
ELIZABETH ANN FITZPATRICK
金额：
$ 2.86万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-08-29 至
项目状态：
未结题

项目摘要

The acquired immunodeficiency syndrome (AIDS) has become a critical health problem in the United States. Infection with the disease-causing lentivirus-HIV-results in a progressive and debilitating immunosuppression. Because of the period between initial infection with HIV and onset of AIDS is quite variable among individuals, it is important to determine the role of co-factors, such as alcohol abuse, in the development of the disease. It has been reported that ethanol consumption has a detrimental effect on the ability of the host to generate humoral and cellular immune responses. Chronic alcohol abuse is common among drug users, a group at high risk for AIDS, and ethanol associated immunosuppression may act synergistically with HIV-induced immunosuppression to shorten the onset of disease and/or increase the severity of disease. We will use the retroviral-induce murine acquired immunodeficiency syndrome (MAIDS) model to determine the effect of acute and chronic ethanol consumption on the development of HIV-associated immunosuppression. Experiments are designed to determine the effect of ethanol on the replication of the MAIDS virus mixture in infected animals. We will also examine the effect of ethanol on the percentage of T and B cells which are activated by virus infection as well as the subsets of T and B cells responsible for the lymphoproliferation. Finally we will examine the mechanisms of retroviral-induce immunosuppression and the effect of ethanol consumption on generation of these mechanisms.

获得的免疫缺陷综合征（AIDS）已成为关键美国的健康问题。引起疾病的感染慢病毒hiv-在进步和衰弱的免疫抑制。由于在初次感染之间艾滋病毒和艾滋病的发作是个体的变化，是重要的是确定共同因素（例如酗酒）在疾病的发展。据报道乙醇消费对宿主的能力有害产生体液和细胞免疫反应。慢性酒精滥用是在吸毒者中很常见，艾滋病高风险和乙醇的群体相关的免疫抑制可能会与HIV诱导的免疫抑制以缩短疾病的发作和/或增加疾病的严重程度。我们将使用获得的逆转录病毒诱导鼠免疫缺陷综合征（女仆）模型以确定急性的影响和慢性乙醇消耗有关HIV相关的发展免疫抑制。实验旨在确定乙醇在被感染的女仆病毒混合物复制的复制中动物。我们还将检查乙醇对百分比的影响被病毒感染激活的T和B细胞以及 T和B细胞的子集负责淋巴增生。最后，我们将检查逆转录病毒诱导的机制免疫抑制和乙醇消耗对产生的影响这些机制。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Activation-dependent apoptosis in CD4+ T cells during murine AIDS.

小鼠艾滋病期间 CD4 T 细胞的激活依赖性凋亡。

DOI：
10.1006/cimm.1993.1248
发表时间：
1993
期刊：
Cellular immunology
影响因子：
4.3
作者：
Cohen,DA;Fitzpatrick,EA;Barve,SS;Guthridge,JM;Jacob,RJ;Simmerman,L;Kaplan,AM
通讯作者：
Kaplan,AM

Ethanol as a possible cofactor in the development of murine AIDS.

乙醇作为小鼠艾滋病发展的可能辅助因子。