Impact of COVID-19 on AD Occurrence: A Biracial Intergenerational Population Study

COVID-19 对 AD 发生的影响：一项双种族代际人口研究

基本信息

批准号：
10280919
负责人：
NEELUM T. AGGARWAL
金额：
$ 319.05万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10280919
关键词：
2019-nCoV Acute Address Administrative Supplement African American Age Aging Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Antibodies Area Award Biological Markers Blood Blood Vessels Body mass index Brain Injuries COVID-19 COVID-19 outbreak Censuses Chicago Chronic Clinical Cognition Cognitive Communities Death Rate Dementia Diffusion Magnetic Resonance Imaging Disease Outbreaks Elderly Environment Epidemiology Ethnic Origin European Family Female Gender Generations Goals Health Hippocampus (Brain)Hypertension Immunity Impaired cognition Impairment Incidence Individual Infection Inflammatory Life Style Longevity Longitudinal Studies Magnetic Resonance Imaging Minority Outcome Parents Participant Pattern Population Population Heterogeneity Population Study Prevalence Prevention strategy Preventive Public Health RNA Race Reporting Research Risk Risk Factors Role SARS-CoV-2 infection SARS-CoV-2 transmission Sampling Serology Social Characteristics Social Distance Structure Testing Therapeutic Therapeutic Studies White Matter Hyperintensity Woman Work aging brain biracial brain health clinical Diagnosis cognitive testing cohort coronavirus disease cytokine dementia risk demographics genetic risk factor high risk high risk parents infection rate inflammatory marker innovation intergenerational male middle age neuroimaging novel offspring parent project population based population health prehypertension racial disparity research clinical testing sex social social disadvantage social engagement statistics trend vascular risk factor

项目摘要

The Chicago Health and Aging Project (CHAP) has made several significant contributions to Alzheimer's disease and related dementias (ADRD) epidemiology. These areas include racial disparities, prevalence, and incidence of dementia trends, social, lifestyle, vascular, genetic risk factors, and neuroimaging and blood biomarkers in a large population-based community study of African Americans (AAs) and European Americans (EAs). Using the older CHAP parent and the ongoing midlife offspring cohorts, we will test several novel and innovative hypotheses on the impact of COVID-19 on ADRD, MCI, cognitive decline, and structural MRI brain injury. By extending the awarded NIA NOSI Administrative Supplement, the intergenerational study provides significant advantages by investigating: (1) the direct effect of SARS-CoV-2 infections amongst those with higher inflammatory cytokines, especially in families with a high risk of COVID-19 transmission, which leads to adverse cognitive outcomes; and (2) an indirect effect of COVID-19 outbreak-imposed changes in physical and cognitive activities, social engagement, and vascular risk factors in a shared family environment in diverse communities. To address this scientific area of research, we propose to conduct a biracial population-based community study of 4,000 older CHAP parents with two population cognitive assessments and detailed clinical evaluations for ADRD in 1,200 participants with the following specific aims: (1) Estimate the 2020 US census demographic adjusted overall and demographic-specific (age, race/ethnicity, and gender) prevalence and incidence of ADRD, MCI, and dementia likelihood and test whether the prevalence and incidence have changed before and after COVID-19. Also, test whether the 5-year risk of ADRD among high-risk AA parents has high-risk offspring compared to EAs; (2) Examine the change in physical and cognitive activities, social engagement, BMI, and hypertension from pre- to post-COVID and the impact of these changes on the risk of ADRD, MCI, cognitive decline, and MRI brain injury. Also, test whether these associations are higher by age, sex (males vs. females), and among AA parents and offspring compared to EA parents and offspring; (3) Test whether participants with SARS-CoV-2 RNA infections and serology antibodies and elevated concentrations of inflammatory cytokines among those with higher vascular risk factors have a higher risk of ADRD, MCI, cognitive decline, and structural MRI brain injury. Also, test whether these associations are higher among AA parents and offspring compared to EAs. This proposal has an enormous public health impact in developing preventive strategies and therapeutic studies on the impact of COVID-19 on population health across generations from midlife to late-life in a diverse population with socially disadvantaged AA minorities.

芝加哥健康与老龄化项目 (CHAP) 对阿尔茨海默病做出了多项重大贡献疾病及相关痴呆（ADRD）流行病学。这些领域包括种族差异、患病率和痴呆症的发病率趋势、社会、生活方式、血管、遗传危险因素以及神经影像学和血液一项针对非裔美国人 (AA) 和欧洲裔美国人的大型人群社区研究中的生物标志物（EA）。使用年长的 CHAP 父母和正在进行的中年后代队列，我们将测试一些新颖且关于 COVID-19 对 ADRD、MCI、认知能力下降和大脑结构 MRI 影响的创新假设受伤。通过扩展已授予的 NIA NOSI 行政补充，代际研究提供了通过调查以下方面的显着优势：(1) SARS-CoV-2 感染对感染率较高的人群的直接影响炎性细胞因子，特别是在具有 COVID-19 传播高风险的家庭中，这会导致不良反应认知结果； (2) COVID-19 爆发造成的身体和认知变化的间接影响不同社区共享家庭环境中的活动、社会参与和血管危险因素。为了解决这一科学研究领域，我们建议进行一项基于混血人口的社区研究对 4,000 名老年 CHAP 父母进行了两项群体认知评估和详细的临床评估 ADRD 在 1,200 名参与者中进行，其具体目标如下：(1) 估算 2020 年美国人口普查人口调整了 ADRD 的总体和特定人口（年龄、种族/民族和性别）患病率和发生率， MCI 和痴呆可能性并测试患病率和发病率前后是否发生变化新冠肺炎。另外，测试高危 AA 父母的 5 年 ADRD 风险是否会产生高危后代与 EA 相比； (2) 检查身体和认知活动、社会参与、BMI 和新冠肺炎前后的高血压以及这些变化对 ADRD、MCI、认知能力的影响衰退和 MRI 脑损伤。另外，测试这些关联是否因年龄、性别（男性与女性）、 AA 亲本和后代与 EA 亲本和后代之间的比较； (3) 测试参与者是否 SARS-CoV-2 RNA 感染和血清学抗体以及炎症细胞因子浓度升高具有较高血管危险因素的人群中，ADRD、MCI、认知能力下降和结构性心脏病的风险较高 MRI 脑损伤。另外，测试 AA 父母和后代中的这些关联是否比 AA 父母和后代更高 EA。该提案对于制定预防策略和治疗方法具有巨大的公共卫生影响关于 COVID-19 对从中年到晚年各代人的人口健康影响的研究社会弱势 AA 少数民族人口。