Neural basis of behavior in freely moving macaques

自由移动猕猴行为的神经基础

• 批准号: 10275271
• 负责人: BENJAMIN Y HAYDEN
• 金额: $ 74.17万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10275271
• 关键词: 3-Dimensional; Address; Animal Model; Animals; Anterior; Anxiety Disorders; Architecture; Area; Behavior; Behavior Control; Behavioral; Brain; Brain region; Cognition; Cognitive; Data; Dimensions; Disease; Dorsal; Eating; Electrodes; Electrophysiology (science); Environment; Failure; Goals; Health Benefit; Human; Implant; Joints; Laboratories; Link; Macaca; Macaca mulatta; Maintenance; Mental Depression; Mental Health; Monkeys; Motor; Movement; Mus; Neurons; Pattern; Population; Positioning Attribute; Prefrontal Cortex; Primates; Process; Ramp; Regulation; Research; Role; Sampling; Structure; System; Testing; Walking; Work; addiction; adjudicate; base; body position; cingulate cortex; cognitive function; comorbidity; experimental study; fly; high dimensionality; improved; insight; interest; neuroregulation; relating to nervous system; response; temporal measurement

Abstract Behavior and its associated executive processes can be categorized into lower-level movements, but also into higher-level states. States are controlled on a moment-to-moment basis by goals and likely implemented by specific brain circuits, including dorsal prefrontal cortical structures. The ability to properly select behaviors and to switch between them is critical for healthy cognitive functioning. Disruption of state control is a hallmark of addiction. Understanding how the brain implements and switches between states therefore offers the hope of improve their control. The central premise of this proposal is that understanding the neural control of states in macaques can help us understand neural control of states more generally. We believe this is best done in freely moving animals because behavioral expression is too constrained to be interpretable in typical laboratory contexts. A major barrier is the difficulty in tracking macaques’ body positions, which is essential for state identification. We have recently solved the tracking problem. Using an electrophysiological recording system amenable to recording in a freely moving environment, we will record responses of hundreds of neurons in dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC). These cortical regions, which are unique (dlPFC) or greatly modified (dACC) in the primate order, are strongly associated with control of behavior, are associated with simple cognitive states and with regulation of behavior in humans, and are prominently dysregulated in addiction. They also have strong and direct projections to the primary and secondary motor systems, putting them in an ideal position to drive behavior, and suggesting they may have a high-level relationship with control of behavior. However, while they are linked to these processes, we know almost nothing about their neuron-level relationship with control of behavior. We will place animals in our large cage system and have them perform a foraging task in which they naturally cycle through behaviors and then link them with brain activity in dACC and dlPFC. This will let us resolve several outstanding issues, including what role these regions have in behavioral control and how they relate to each other.

抽象的 行为及其相关的执行过程可以分为较低级别的运动，但是 国家也受到目标和可能的控制。 由特定的大脑回路实现，包括背侧前额皮质结构。 选择行为并在它们之间切换对于健康的认知功能的破坏至关重要。 控制是成瘾的一个标志。了解大脑如何实现和在状态之间切换。 因此，该提案的核心前提是了解改善他们的控制的希望。 猕猴状态的神经控制可以帮助我们更普遍地理解状态的神经控制。 相信这最好在自由活动的动物身上进行，因为行为表达太受限而无法 在典型的实验室环境中可以解释的一个主要障碍是追踪猕猴的身体位置的困难， 这对于状态识别至关重要。我们最近解决了跟踪问题。 电生理记录系统适合在自由移动的环境中进行记录，我们将记录 背侧前扣带皮层 (dACC) 和背外侧前额叶数百个神经元的反应 这些皮层区域在灵长类动物中是独特的 (dlPFC) 或经过很大修改 (dACC)。 秩序，与行为控制密切相关，与简单的认知状态相关，并且与 人类行为的调节，并且在成瘾方面显着失调。 直接投射到主电机系统和辅助电机系统，它们处于驱动推杆的理想位置 行为，并表明他们可能与行为控制有高层关系。 与这些过程有关，我们对它们与控制的神经水平关系几乎一无所知 我们将动物放入大型笼子系统中，让它们执行觅食任务。 自然地循环行为，然后将它们与 dACC 和 dlPFC 中的大脑活动联系起来。 解决几个悬而未决的问题，包括这些区域在行为控制中发挥什么作用以及它们如何 彼此相关。