Improving Alcohol Use Disorder Treatment for Gender Minority Populations

改善性别少数人群的酒精使用障碍治疗

基本信息

批准号：
10224042
负责人：
Jeremy D Kidd
金额：
$ 18.28万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10224042
关键词：
Academy Address Adult Affect Alcohol consumption Alcohols Area Award Behavioral Model Biometry Birth Caring Child Clinical Clinical Investigator Clinical Treatment Clinical Trials Cultural Sensitivity Data Data Analyses Discrimination Distress Divorce Drug Use Disorder Drug usage Effectiveness Ensure Epidemiology Family Friends Fright Gender Gender Identity General Population Goals Grant Health Heavy Drinking Heterosexuals Hormonal Individual Interpersonal Relations Intervention Interview Life Experience Longitudinal cohort Mediating Medicine Mentorship Methodology Methods Minority Groups Operative Surgical Procedures Patients Physicians Population Population Intervention Population Research Prevalence Prevention Process Psychotherapy Qualitative Research Randomized Reporting Research Research Personnel Risk Factors Role Scientist Sex Differences Sex Discrimination Sexual and Gender Minorities Site Social support Stigmatization Structure Substance Use Disorder Therapeutic Studies Training United States National Institutes of Health Value of Life Violence Writing addiction alcohol abuse therapy alcohol intervention alcohol risk alcohol use disorder arm base binge drinking career cohort drinking efficacy trial evidence base experience feasibility trial gender minority gender nonconforming gender transition hazardous drinking health disparity improved innovation interpersonal therapy maltreatment marginalized population member motivational enhancement therapy neglect peer psychologic psychological distress psychosocial resilience sex social stigma substance use treatment transgender treatment program treatment research treatment strategy

项目摘要

Project Summary: Gender minority individuals (GM; transgender and gender non-conforming), an NIH- designated disparity population (NOT-MD-19-001), experience numerous health disparities including high rates of hazardous drinking and alcohol use disorder (AUD). GMs also have culturally-distinct life experiences that can further increase alcohol risk. Standard alcohol treatment programs often neglect such GM-specific experiences. Cultural adaptation can improve treatment acceptability, retention, and effectiveness in minority populations by increasing treatment compatibility with patients’ cultural norms/values. Despite alcohol disparities and unique risk factors, there are no evidence-based alcohol interventions for this marginalized population. In this application, Dr. Jeremy Kidd proposes a comprehensive path toward becoming an independent physician-researcher of innovative treatments for alcohol and drug use disorders among GMs. Specifically, this proposal follows the Stage Model of Behavioral Therapies Research to develop and evaluate the feasibility of a culturally-adapted psychosocial intervention for AUD among GMs. Cultural adaptation will address the specific types of interpersonal disruptions (e.g., with family, friends, coworkers) that many GMs experience due to gender transition or anti-GM discrimination/stigma. These disruptions result in interpersonal distress that increases alcohol risk. In Stage 0 formative research, Dr. Kidd will use latent class analysis to examine the relationship between social support and trajectories of hazardous drinking in an established multi-site, longitudinal cohort of GMs (N = 330). Next, he will employ qualitative descriptive methodologies to conduct individual semi-structured interviews with cohort members (N = 48) to understand in-depth how interpersonal factors influence GM drinking. He will use these formative findings to develop a culturally-adapted AUD intervention for GMs. He will use interpersonal psychotherapy (IPT) as a platform for adaptation because it is evidence-based for alleviating interpersonally-mediated psychological distress. Finally, Dr. Kidd will evaluate this intervention’s feasibility by delivering it to 20 GM individuals with AUD in a Stage 1 single-arm, pre-post, mixed-methods feasibility trial. To further his long-term career goal of becoming an independent clinical researcher focused on GM addiction disparities, Dr. Kidd will pursue training in the following 5 areas: (1) advanced epidemiology and biostatistics with longitudinal and clinical trials data, (2) qualitative research, (3) psychosocial intervention adaptation, (4) psychotherapy clinical trials, and (5) grant writing. The results of this study will be the first application of the Stage Model of Behavioral Therapies Research in GM populations and the first evidence-based psychosocial alcohol treatment for GMs. This approach may also inform clinical treatment research for other GM health disparities. Overall, this award will ensure Dr. Kidd’s successful transition to an independent clinical investigator studying prevention and treatment of substance use disorders in GM populations.

项目摘要：性别少数群体（GM；跨性别者和性别不合格者），NIH- 指定的差异人群 (NOT-MD-19-001)，经历许多健康差异，包括高比率危险饮酒和酒精使用障碍 (AUD) 的 GM 也具有不同文化的生活经历。标准的酒精治疗方案常常忽视这种特定于转基因的经历。文化适应可以通过以下方式提高少数群体的治疗可接受性、保留率和有效性：尽管存在酒精差异和独特性，但仍提高治疗与患者文化规范/价值观的兼容性。危险因素，目前还没有针对这一边缘人群的基于证据的酒精干预措施。在此申请中，杰里米·基德 (Jeremy Kidd) 博士提出了一条成为独立人士的全面路径 GM 中酒精和药物使用障碍创新治疗的医生研究员。提案遵循行为疗法研究的阶段模型来开发和评估可行性 GM 中针对 AUD 的文化适应心理社会干预文化适应将解决具体问题。许多总经理因性别而经历的人际干扰类型（例如，与家人、朋友、同事）转型或反转基因歧视/耻辱会导致人际交往困难加剧。在第 0 阶段形成性研究中，基德博士将使用潜在类别分析来检查这种关系。在已建立的多地点纵向队列中，研究社会支持与危险饮酒轨迹之间的关系接下来，他将采用定性描述方法来进行个人半结构化。对队列成员 (N = 48) 进行访谈，以深入了解人际因素如何影响转基因饮酒。他将利用这些形成性的发现为总经理制定适合文化的 AUD 干预措施。人际心理治疗（IPT）作为适应平台，因为它是基于证据的缓解最后，基德博士将通过以下方式评估这种干预措施的可行性。在第一阶段单臂、前后、混合方法可行性试验中，将其以澳元交付给 20 名 GM 个人。进一步推进他成为专注于转基因成瘾的独立临床研究员的长期职业目标为了解决这种差异，Kidd 博士将在以下 5 个领域进行培训：(1) 高级流行病学和生物统计学纵向和临床试验数据，(2) 定性研究，(3) 心理社会干预适应，(4) 心理治疗临床试验，以及（5）拨款写作本研究的结果将是该阶段的首次申请。转基因人群的行为治疗研究模型和第一个基于证据的心理社会酒精这种方法也可以为其他转基因健康差异的临床治疗研究提供信息。总体而言，该奖项将确保基德博士成功转型为独立临床研究者预防和治疗转基因人群的物质使用障碍。