MIND Institute Intellectual and Developmental Disabilities Research Center
MIND 研究所智力与发育障碍研究中心
基本信息
- 批准号:10220100
- 负责人:
- 金额:$ 125.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-21 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:22qAddressAffectAngelman SyndromeAntibodiesAreaAttention deficit hyperactivity disorderAutoantibodiesBasic ScienceBehaviorBehavior TherapyBehavioralBioinformaticsBiologicalBiological AssayBiological MarkersBiological ModelsBiological Response Modifier TherapyBiometryCaliforniaChildChromosomesClinicalClinical DataClinical SciencesCommunicationCommunitiesComplexDataDevelopmentDiGeorge SyndromeDiagnosisDisciplineDown SyndromeEducationEnsureEnvironmental ExposureEpigenetic ProcessExposure toFMR1FacultyFamilyFosteringFragile X SyndromeFundingGeneticGenetic Predisposition to DiseaseHeterogeneityHomeHumanImmune System DiseasesIndividualInstitutesIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityInternationalInterventionLeadershipMeasuresMedical centerModelingMolecular AnalysisMothersMusNational Institute of Child Health and Human DevelopmentNatureNeuroimmuneOutcomeOutcome MeasureParticipantPathway interactionsPeer ReviewPhenotypePolicy MakerPreclinical Drug EvaluationPregnancyPrevention approachProcessRattusResearchResearch DesignResearch PersonnelResearch Project GrantsResourcesRiskRodentRodent ModelRoleRouteSamplingSchoolsScienceServicesSiteSourceStatistical Data InterpretationStructureSystems AnalysisTechnologyTeratogensTestingTrainingTranslational ResearchTreatment EfficacyUnited States National Institutes of HealthUniversitiesassociated symptomautism spectrum disorderbiobehaviorbiomarker developmentbrain abnormalitiescatalystcellular imagingclinical carecohortcollegecost effectivedigitaldisorder riskdrug efficacyelectronic dataevidence basegene environment interactionhealth care disparityhealth disparityhigh riskimmune functionimprovedinnovationinsightinterdisciplinary collaborationmedication safetymolecular imagingmultidimensional datamutantneurodevelopmentoperationoutreachpreventprogramsrecruitsocial disparities
项目摘要
PROJECT SUMMARY – OVERALL
The present application seeks funding to continue the MIND Institute Intellectual and Developmental
Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013
and is the newest of the 14 IDDRCs in the network. The MIND Institute IDDRC will address four specific aims.
Aim 1 is to conduct interdisciplinary translational research that yields insights into the nature, causes, and
consequences of IDD and leads to innovative evidence-based approaches to prevention and treatment. To this
end, we propose 81 externally funded projects that reflect the themes of Integrated Biobehavioral
Characterization of IDD, Genetic and Environmental Contributions to IDD, and Treatment of IDD. These projects
are led by 43 investigators from 16 academic departments and 5 schools/colleges. 68 projects are funded by the
NIH, including 16 by NICHD. Aim 2 is to accelerate the pace of interdisciplinary translational research via the
operation of cost-effective, innovative, and widely used scientific cores. In addition to an Administrative Core, we
propose four scientific cores. The Clinical Translational Core will facilitate recruitment of diverse samples of
human participants, provide specialized clinical expertise to diagnose and characterize participants, support
complex phenotyping, collect and store biospecimens, and integrate digital technologies into treatment studies.
The Biological and Molecular Analysis Core will provide access to expertise and technologies in the areas of
immune function, cellular and molecular imaging, epigenetics, and environmental exposures as they relate to
neural development. The Rodent Behavior Core will provide assays of mouse and rat behavior, guidance in the
development of mutant rodent models, and support for preclinical evaluations of drug safety and efficacy. The
Biostatistics, Bioinformatics, and Research Design Core will provide support for study design, creation of
electronic data capture and management systems, and statistical analysis of complex multidimensional datasets.
Aim 3 is to improve the lives of people with IDD and reduce health and social disparities in care by developing
a robust plan for disseminating and implementing scientific discoveries. The plan will involve multiple paths of
communication to target professionals and policy makers, reach diverse communities, while being informed by
the perspectives of people with IDD and their families. Aim 4 is to conduct a signature research project that
examines the heterogeneity of outcomes and mechanisms underlying those outcomes in maternal autoantibody
related (MAR) autism spectrum disorder (ASD), which may account for as much as 20% of ASD cases. The
project will make use of existing human clinical data to inform the creation of rat model systems to test
hypotheses about causal mechanisms. The signature project addresses three RFA themes: Preventing and
mitigating the impact of exposures that can cause IDD, Outcome measures or biomarkers for interventions or
treatments, and Development of biomarkers or assessment measures in more than one IDD condition.
项目概要——总体
本申请寻求资金以继续 MIND 研究所智力与发展
加州大学戴维斯分校残疾人研究中心 (IDDRC) 于 2013 年成立。
它是网络中 14 个 IDDRC 中最新的一个。 MIND Institute IDDRC 将致力于实现四个具体目标。
目标 1 是进行跨学科转化研究,深入了解其本质、原因和
IDD 的后果并导致创新的循证预防和治疗方法。
最后,我们提出了 81 个反映综合生物行为主题的外部资助项目
IDD 的特征、IDD 的遗传和环境贡献以及 IDD 的治疗这些项目。
由来自 16 个学术部门的 43 名研究人员领导,68 个项目由 5 个学院/学院资助。
NIH,包括 NICHD 的 16 个目标 2 是通过以下方式加快跨学科转化研究的步伐。
除了管理核心之外,我们还运营经济高效、创新且广泛使用的科学核心。
提出四个科学核心,临床转化核心将促进不同样本的招募。
人类参与者,提供专业的临床专业知识来诊断和表征,支持
复杂的表型分析、收集和存储生物样本,并将数字技术整合到治疗研究中。
生物和分子分析核心将提供以下领域的专业知识和技术:
免疫功能、细胞和分子成像、表观遗传学以及与相关的环境暴露
啮齿动物行为核心将提供小鼠和大鼠行为的分析,并为神经发育提供指导。
突变啮齿动物模型的开发,并支持药物安全性和有效性的临床前评估。
生物统计学、生物信息学和研究设计核心将为研究设计、创建
电子数据采集和管理系统,以及复杂多维数据集的统计分析。
目标 3 是通过发展 IDD 患者的生活并减少护理方面的健康和社会差距
一个传播和实施科学发现的强有力的计划 该计划将涉及多种途径。
与目标专业人士和政策制定者进行沟通,接触不同的社区,同时了解
目标 4 是开展一项标志性研究项目,以了解 IDD 患者及其家人的观点。
检查母体自身抗体结果的异质性和这些结果背后的机制
相关 (MAR) 自闭症谱系障碍 (ASD),可能占 ASD 病例的 20%。
项目将利用现有的人类临床数据来创建大鼠模型系统以进行测试
该签名项目涉及三个 RFA 主题:预防和预防。
减轻可能导致 IDD 的暴露影响、干预措施的结果测量或生物标志物或
治疗,以及针对一种以上 IDD 状况开发生物标志物或评估措施。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('LEONARD J. ABBEDUTO', 18)}}的其他基金
Telehealth-delivered outcome measures for Spanish- and English-speaking people with Down syndrome
远程医疗为讲西班牙语和英语的唐氏综合症患者提供结果测量
- 批准号:
10730307 - 财政年份:2023
- 资助金额:
$ 125.2万 - 项目类别:
MIND Institute Intellectual and Developmental Disabilities Research Center
MIND 研究所智力与发育障碍研究中心
- 批准号:
10085147 - 财政年份:2020
- 资助金额:
$ 125.2万 - 项目类别:
MIND Institute Intellectual and Developmental Disabilities Research Center
MIND 研究所智力与发育障碍研究中心
- 批准号:
10682390 - 财政年份:2020
- 资助金额:
$ 125.2万 - 项目类别:
MIND Institute Intellectual and Developmental Disabilities Research Center
MIND 研究所智力与发育障碍研究中心
- 批准号:
10682390 - 财政年份:2020
- 资助金额:
$ 125.2万 - 项目类别:
MIND Institute Intellectual and Developmental Disabilities Research Center
MIND 研究所智力与发育障碍研究中心
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Effects of AFQ056 on Language Learning in Young Children with Fragile X Syndrome (FXS)
AFQ056 对患有脆性 X 综合征 (FXS) 的幼儿语言学习的影响
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9120161 - 财政年份:2016
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