Central Hub for Kidney Precision Medicine - Administrative Core

肾脏精准医学中心中心 - 行政核心

基本信息

批准号：
10218145
负责人：
Jonathan Himmelfarb
金额：
$ 213.41万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-09-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218145
关键词：
Accounting Acute Renal Failure with Renal Papillary Necrosis Address Affect Award Biomedical Research Budgets Cells Chronic Kidney Failure Clinical Data Clinical Protocols Clinical Research Collaborations Collection Communication Communities Community Health Education Community Outreach Complex Critiques Development Disease Disease Progression Education and Outreach Enrollment Ethicists Fostering Funding Funding Agency Funding Opportunities Genomics Goals Human Resources Information Dissemination Information Systems Informed Consent Infrastructure Institution Institutional Review Boards Internal Medicine Kidney Kidney Diseases Laboratories Length of Stay Modeling Modernization Nephrology Operations Research Organ Participant Pathway interactions Patients Performance Pharmaceutical Preparations Policies Prevention Principal Investigator Procedures Process Protocols documentation Provider Public Health Publications Publishing Quality Control Quality of life Randomized Clinical Trials Renin-Angiotensin System Research Research Personnel Research Project Grants Research Training Review Committee Running Science Scientist Site Therapeutic Tissues Translating Translational Research United States National Institutes of Health base clinical Diagnosis disorder subtype epigenomics ethical legal social implication experience improved inhibitor/antagonist kidney biopsy medical specialties meetings mortality multidisciplinary new therapeutic target novel strategies operation participant safety patient engagement patient oriented precision medicine program dissemination programs protocol development recruit shared decision making success tissue processing working group

项目摘要

ABSTRACT A major challenge for modern biomedical research has been the relative inability to translate the increasing rate of scientific discovery into major therapeutic breakthroughs. This shortcoming has been particularly dramatic in kidney diseases, where the number of randomized clinical trials published in nephrology is fewer than all other specialties of internal medicine. Chronic kidney disease (CKD) is a public health problem affecting more than 20 million people in the US, few drugs other than inhibitors of the renin-angiotensin system have been proven to slow CKD progression, lower mortality rates, or improve quality of life. Acute kidney injury (AKI) affects up to 10% of all hospitalized patients in the US, and is associated with mortality, prolonged hospital length of stay, and subsequent development or progression of CKD. Currently there is no accepted therapeutic approach to either prevention or amelioration of the course of AKI There is a critical need to help define CKD and AKI disease subgroups and identify critical cells, pathways and targets for novel therapies. We propose to establish a multiscale understanding of CKD and AKI, by integrating clinical data with the cell and organ level features of kidney disease progression including interrogation of genomic and epigenomic drivers of disease. We plan to build the Kidney Precision Medicine Project Central Hub on strong existing infrastructure led by a highly experienced, multidisciplinary team with a strong track record of success. The overarching objective of the KPMP Administrative Core is to facilitate successful interdisciplinary team science by fostering communication, collaboration, and coordination among the KPMP Steering Committee (SC), components of the Central Hub, Recruitment Sites, Tissue Interrogation Sites, EEP, OSMB, IRB and sponsor. The overall goal of this team science is to promote scientific rigor and participant safety in order to advance kidney precision medicine. As a key component of this model, the Administrative Core will have primary responsibility for coordinating the operations of the KPMP, establishing necessary working groups and relationships, forming and operating a Patient Engagement Working Group, and administering an Opportunity Pool to form new partnerships. The Administrative Core will additionally provide project management, budgeting, and fiscal management for all Central Hub activities. The Administrative Core will be responsible for overall day-to-day center operations, research, research training and education, and community outreach activities, including information dissemination

抽象的现代生物医学研究的一个主要挑战是相对无法转化科学发现转化为重大治疗突破的速度不断提高。这个缺点有在肾脏疾病中尤其引人注目，其中随机临床试验的数量肾脏病学领域发表的论文少于内科所有其他专业。慢性肾病慢性肾病 (CKD) 是一个影响美国超过 2000 万人的公共卫生问题，药物很少除了肾素-血管紧张素系统抑制剂已被证明可以减缓 CKD 进展之外，降低死亡率，或提高生活质量。急性肾损伤 (AKI) 影响高达 10% 在美国住院的患者，与死亡率、住院时间延长、以及 CKD 的后续发展或进展。目前尚无公认的治疗方法预防或改善 AKI 病程的方法迫切需要提供帮助定义 CKD 和 AKI 疾病亚组，并确定关键细胞、途径和靶标，以开发新的药物疗法。我们建议通过整合来建立对 CKD 和 AKI 的多尺度理解肾脏疾病进展的细胞和器官水平特征的临床数据，包括询问疾病的基因组和表观基因组驱动因素。我们计划打造肾脏精密医学项目中心枢纽拥有强大的现有基础设施，由经验丰富、多学科团队拥有良好的成功记录。 KPMP 的总体目标行政核心是通过培养跨学科团队科学的成功 KPMP 指导委员会 (SC) 之间的沟通、协作和协调，中央枢纽、招募站点、组织询问站点、EEP、OSMB、IRB 的组成部分和赞助商。该团队科学的总体目标是促进科学严谨性和参与者安全性，以推进肾脏精准医学。作为该模型的关键组成部分，行政核心将主要负责协调 KPMP 的运作，建立必要的工作组和关系，组建和运营患者参与工作组，并管理机会池以形成新的合作伙伴关系。这行政核心还将提供项目管理、预算和财务管理所有中央枢纽活动。行政核心将全面负责日常中心运营、研究、研究培训和教育以及社区外展活动，包括信息传播