The biophysics and potential cell-type selectivity of acoustic neuromodulation

声神经调节的生物物理学和潜在的细胞类型选择性

基本信息

批准号：
10218280
负责人：
Robert Crooks Froemke
金额：
$ 68.34万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218280
关键词：
Acoustics Anatomy Attention Behavioral Biophysics Brain Brain Mapping Characteristics Clinical Computer Models Data Development Diagnosis Environment Focused Ultrasound Functional Imaging Geometry Goals Hippocampus (Brain)Image Interneurons Lead Measures Mediating Membrane Methods Modality Modeling Mus Neurons Neurosciences Output Physiologic pulse Protocols documentation Radiation Research Resolution Role Shapes Somatostatin Stimulus Structure Surface Testing Thalamic structure Tissues Transgenic Mice Ultrasonic wave Ultrasonics Ultrasonography Validation Viscosity awake cell type experimental study flexibility in vivo insight mathematical analysis neglect nervous system disorder neuroregulation novel optogenetics predictive modeling pressure relating to nervous system response scaffold sensory input simulation software spatiotemporal theories tool two photon microscopy two-photon vibration

项目摘要

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function, the causal testing of neurotheoretic models, and the diagnosis and treatment of neurological disorders. The proposed five-year project is aimed at uncovering the fundamental mechanisms of US stimulation through the reciprocity of mathematical analysis, computational modeling and experimental validation. Using a previously developed predicative model as a scaffold, we will build a full explanatory theory of US stimulation effects in mice, including cell-type specific effects of this perturbation modality. A large parameter space of US variables will be explored, including spatiotemporal dynamics and duty cycle modulation, while sensitive two-photon functional imaging metrics will be used to measure the biophysical impact of these parameters on neural responses in the cortex, thalamus, and hippocampus in vivo.

概括神经科学对大规模扰动工具有基本要求。这样的工具将在绘制大脑功能、因果测试等方面带来变革神经理论模型以及神经系统疾病的诊断和治疗。这拟议的五年项目旨在揭示美国的基本机制通过数学分析、计算建模和实验验证。使用先前开发的预测模型作为支架，我们将建立美国刺激效应对小鼠的完整解释理论，包括细胞类型特异性这种扰动模式的影响。将探索 US 变量的大参数空间，包括时空动力学和占空比调制，同时敏感的双光子功能成像指标将用于测量这些参数的生物物理影响体内皮质、丘脑和海马的神经反应。