Enabling the Next Generation of High Performance Pediatric Whole Body MR Imaging

实现下一代高性能儿科全身 MR 成像

• 批准号: 10218169
• 负责人: Michael Lustig
• 金额: $ 83.9万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10218169
• 关键词: 10 year old; 8 year old; Acclimatization; Acoustics; Adult; Age; Anatomy; Anesthesia procedures; Body part; Brain; Caliber; Caregivers; Child; Child Health; Childhood; Cone; Coupled; Custom; Development; Diffusion Magnetic Resonance Imaging; Electrocardiogram; Electronics; Environment; Equipment; Flare; Goals; Head; Image; Immersion; Infrastructure; Machine Learning; Magnetic Resonance Imaging; Measures; Methods; Morphologic artifacts; Motion; Motivation; Noise; Partner in relationship; Patients; Pediatrics; Performance; Peripheral Nerve Stimulation; Physiologic pulse; Physiological; Preparation; Radiation; Resolution; Respiration; Role; Scanning; Signal Transduction; Speed; Support System; System; T2 weighted imaging; Techniques; Technology; Temperature; Testing; Thinness; Time; Vendor; base; commercialization; contrast imaging; data acquisition; density; design; digital; experience; hemodynamics; image reconstruction; imaging capabilities; imaging system; improved; innovation; next generation; novel; novel strategies; open source; pediatric patients; reconstruction; respiratory; sensor; success; tool; virtual reality; whole body imaging

Project Abstract Motivation: We aim to develop and implement a new approach to transform pediatric MRI. The ultimate goal is ultra-fast and motion-robust imaging in a dedicated child-friendly environment to enable more children undergo MRI without anesthesia. For those who still require anesthesia, it will be briefer and lighter, and performed in a safer environment. This project leverages a small compact magnet, designed for adult brain MRI, with gradients that enable very fast imaging. With this magnet as an outstanding starting point, we will tailor our deep experience and multiple successes in developing new MRI approaches to high-density receiver coils, fast imaging sequences, and new image reconstruction methods to set a new standard for pediatric MRI. Approach: Although the compact scanner is designed for adult heads, with a 37 cm inner diameter, it can accommodate children under eight to ten years of age to image any body part. To transform this system for ideal pediatric scanning, three development aims will be pursued. The first is to enable optimal signal reception. This will be accomplished through creating new receive chain electronics that are matched to the gradient capabilities, for ultra-high bandwidth imaging. This will be coupled to very thin and formed receive arrays that maximize the size of the patient that can be accommodated in the small bore of the scanner. The second aim is to develop methods of obtaining the highest performance out of the system by characterizing and correcting for its imperfections. This will be coupled to a bespoke approach to peripheral nerve stimulation, enabling maximal use of the gradients on each patient. These two developments will then be leveraged for high efficiency and motion robust noncartesian scanning. The final aim is to develop a full environment and infrastructure that is well suited to pediatric imaging. Patient preparation and acclimation to MRI will be enhanced by virtual reality. Support equipment for anesthesia, new physiological sensors, and a novel child-friendly audiovisual system will be created. Significance: The result of this project will be a revolutionary change in the way that MRI is used and per- formed for children. MRI will be more available, cheaper, safer, and have markedly improved image quality.

项目摘要 动机：我们的目标是开发和实施一种新方法来改变儿科 MRI，最终目标是。 在专门的儿童友好环境中进行超快速和运动鲁棒成像，使更多的儿童能够接受 对于那些仍然需要麻醉的人来说，MRI 会更简短、更轻松，并且可以进行。 该项目利用了专为成人大脑 MRI 设计的小型紧凑型磁铁。 以这种磁铁为出色的起点，我们将定制我们的梯度，从而实现非常快速的成像。 在快速开发高密度接收线圈的新 MRI 方法方面拥有丰富的经验和多次成功 成像序列和新的图像重建方法为儿科 MRI 设定了新标准。 做法：虽然紧凑型扫描仪是为成人头部设计的，内径为 37 厘米，但它可以 适合八到十岁以下的儿童对任何身体部位进行想象，以实现理想的系统转变。 儿科扫描将追求三个发展目标，第一个是实现最佳信号接收。 将通过创建与梯度功能相匹配的新接收链电子设备来实现， 用于超高带宽成像，这将与非常薄且成型的接收阵列相结合，从而最大化。 第二个目标是可以容纳在扫描仪的小孔中的患者的尺寸。 通过表征和校正来开发获得系统最高性能的方法 它的缺陷将与周围神经刺激的定制方法相结合，从而实现最大程度的发挥。 然后，将利用这两项进展来实现高效率和高效率。 运动稳健的非笛卡尔扫描的最终目标是开发一个完整的环境和基础设施。 虚拟现实将增强患者对 MRI 的准备和适应。 麻醉支持设备、新的生理传感器和新颖的儿童友好视听系统将 被创建。 意义：该项目的结果将是 MRI 的使用和执行方式发生革命性变化。 为儿童设计的 MRI 将更容易获得、更便宜、更安全，并且图像质量显着提高。