Enhancing Osseointegration of PEEK with Straight Forward Chemical Derivation Strategy

通过直接的化学衍生策略增强 PEEK 的骨整合

• 批准号: 10219155
• 负责人: Boyle C. Cheng
• 金额: $ 20.15万
• 依托单位: ALLEGHENY-SINGER RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219155
• 关键词: Adsorption; BMP2 gene; Behavior; Binding; Biological; Bone Growth; Cell Adhesion; Cell Culture Techniques; Cell Differentiation process; Cell-Matrix Junction; Cells; Ceramics; Characteristics; Charge; Chemicals; Chemistry; Cytoskeleton; Data; Defect; Dental; Derivation procedure; Devices; Discipline; Distal; Ethers; Exhibits; Failure; Femur; Film; Fostering; Foundations; Future; Growth; Health; Histologic; Hydrophobicity; Immune; Implant; In Vitro; Inflammatory; Innate Immune Response; Ketones; Medical; Metals; Methods; Modeling; Modification; Nature; Operative Surgical Procedures; Orthopedics; Oryctolagus cuniculus; Osseointegration; Osteoblasts; Outcome; Polymers; Procedures; Process; Property; Proteins; Protocols documentation; Publishing; Reaction; Reagent; Sterilization; Surface; Surgical Flaps; Technology; Testing; Time; Tissues; Vertebral column; aqueous; base; biocompatible polymer; biomaterial compatibility; bone; cell growth; cranium; crystallinity; functional group; implant material; implantable device; improved; in vivo; inflammatory marker; insight; long bone; macrophage; maxillofacial; mechanical properties; mineralization; next generation; novel; osteoblast differentiation; response; stem cells; surface coating

Project Abstract: The on growth of bone to in hard tissue implants is a critical factor in the positive health outcomes of these medical procedures. In order for a material to enable bone on growth the implant material’s interface with the body must have a surface conducive for cellular attachment and growth. Therefore methods to improve an implant materials ability to foster cell growth and adhesion are critical for the creation of next generation surgical implant devices and enhanced medical outcomes. Poly(ether ether ketone) (PEEK) is a important biocompatible polymer implant used in a range of hard tissue applications including spine, long bone, skull flap, and orthopedic applications. PEEK’s major limitation relates to its inert surface and lack of surface charge leading to poor cellular attachment and the potential for implant failure. In this proposal we study how a facile aqueous based surface modification of PEEK impacts that materials ability to promote cell growth in vitro and promote bone on growth in vivo.

项目摘要： 骨向硬组织植入物的生长是这些植入物产生积极健康结果的关键因素 为了使材料能够使骨骼生长，植入材料与植入物的界面。 身体必须有一个有利于细胞附着和生长的表面，因此有方法可以改善。 植入材料促进细胞生长和粘附的能力对于创造下一代至关重要 手术植入设备和增强的医疗效果。 聚醚醚酮 (PEEK) 是一种重要的生物相容性聚合物植入物，用于一系列硬组织 PEEK 的主要局限性与脊柱、长骨、颅骨瓣和骨科应用等应用有关。 其惰性表面和缺乏表面电荷导致细胞附着不良和植入的可能性 在本提案中，我们研究了 PEEK 的简便水基表面改性如何影响这一点。 材料能够在体外促进细胞生长并在体内促进骨骼生长。

项目成果

Grafting Polymer Brushes by ATRP from Functionalized Poly(ether ether ketone) Microparticles.

通过 ATRP 从功能化聚醚醚酮微粒接枝聚合物刷。

• 发表时间: 2021-10
• 影响因子: 3.4
• 作者: Fu, Liye;Jafari, Hossein;Gießl, Michael;Yerneni, Saigopalakrishna S;Sun, Mingkang;Wang, Zongyu;Liu, Tong;Kapil, Kriti;Cheng, Boyle C;Yu, Alexander;Averick, Saadyah E;Matyjaszewski, Krzysztof
• 通讯作者: Matyjaszewski, Krzysztof