Cancer Prevention Training: Epidemiology, Nutrition, Genetics & Survivorship

癌症预防培训：流行病学、营养学、遗传学

• 批准号: 10202492
• 负责人: AMANDA IRENE PHIPPS
• 金额: $ 29.91万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2023-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202492
• 关键词: Epidemiology; Genetic; Training; cancer prevention; nutrition; survivorship

PROJECT SUMMARY/ABSTRACT – The interdisciplinary nature of the field of cancer prevention requires a broad spectrum of research skills. In the past 14 years, we have conducted a R25 Training Program which provided multidisciplinary training with emphasis on the relationships of human nutrition, exercise, genetics and related metabolic pathways in cancer susceptibility and prevention. We have had substantial success in trainee degree completion, minority recruitment, and placement of pre- and post-doctoral fellows in research-intensive positions. In this renewal, we are proposing to continue our training as a T32 program with emphasis on the relationships of nutrition, other lifestyle factors, genetics and metabolic pathways in cancer prevention, with an additional emphasis on survivorship. The objectives of this program are to provide trainees with 1) formal coursework in three fields: Epidemiology, Nutrition, and Genetics/Human Biology; trainees whose primary instruction is in one area will complete secondary training in another of these areas; 2) innovative and transdisciplinary research experiences in cancer prevention and survivorship research, with emphasis on human nutrition, genetics and associated metabolic pathways; and 3) skills and practice in grant writing, preparing scientific manuscripts, giving oral presentations and developing a long-term career plan, to promote preparation towards an independent research career. We propose to train 4 pre- and 3 post-doctoral trainees each year. Formal coursework and degrees will be based in three participating programs of the University of Washington: Epidemiology, Nutritional Sciences, and Public Health Genetics. Each trainee will complete a new curriculum developed by this Training Program, including that in a secondary area outside the field of his/her PhD. The curriculum has been continuously revised to reflect emerging areas in cancer biology, the rapidly changing technologies for genetic and biomarker assays and their integration in the broader public health context. Trainees will gain experience in cancer prevention research within three programs of the Fred Hutchinson Cancer Research Center: Cancer Prevention, Epidemiology, and Translational Research. Trainees will have access to the considerable research resources of these three programs, as well as to the 22 exceptional faculty mentors, all of whom have externally funded research in the areas of the Training Program. New mentors have been added as junior faculty members demonstrated research success and to add expertise in new areas (cancer survivorship, omics). Trainees will have mentors from at least two disciplines. The Program Director will be advised by a Steering Committee composed of leaders of the participating programs, as well as by an External Advisory Committee. Trainees who complete this program will have the knowledge and research capabilities to independently conduct cutting edge and impactful translational investigations; we expect that they will become the nation's leaders in cancer prevention research.

项目摘要/摘要——癌症预防领域的跨学科性质 需要广泛的研究技能 在过去 14 年中，我们开展了 R25 培训计划。 它提供多学科培训，重点关注人类营养、运动、 我们在癌症易感性和预防方面的遗传学和相关代谢途径方面取得了实质性进展。 成功完成实习学位、少数族裔招聘以及博士前和博士后研究员的安置 在本次更新中，我们建议继续作为 T32 计划进行培训。 强调营养、其他生活方式因素、遗传和代谢途径在癌症中的关系 预防，特别强调生存 该计划的目标是为受训者提供帮助。 1) 三个领域的正式课程：流行病学、营养学和遗传学/人类生物学实习生； 其主要教学是在一个领域，将完成其中另一个领域的二次培训 2) 在癌症预防和生存研究方面具有创新和跨学科的研究经验， 强调人类营养、遗传学和相关代谢途径；3) 资助的技能和实践； 写作、准备科学手稿、进行口头报告以及制定长期职业计划，以 促进独立研究生涯的准备。 我们建议每年培训 4 名博士前培训生和 3 名博士后培训生。 以华盛顿大学的三个参与项目为基础：流行病学、营养科学、 每位学员将完成该培训计划开发的新课程， 包括他/她的博士学位领域之外的次要领域的课程一直在持续进行。 进行修订以反映癌症生物学的新兴领域、快速变化的遗传和癌症技术 生物标志物测定及其在更广泛的公共卫生背景下的整合，学员将获得以下方面的经验。 弗雷德·哈钦森癌症研究中心三个项目中的癌症预防研究：癌症 预防、流行病学和转化研究。学员将有机会接触到大量的研究成果。 这三个项目的资源，以及 22 位杰出的教师导师，他们都拥有 培训计划领域的外部资助研究已增加为初级导师。 教职人员展示了研究成功并增加了新领域（癌症生存、 组学）。受训者将有至少两个学科的导师。项目主任将由一名导师提供建议。 指导委员会由参与项目的领导者以及外部顾问组成 完成该计划的学员将具备以下知识和研究能力： 独立进行前沿且有影响力的转化研究；我们期望他们能够成为 全国癌症预防研究领域的领导者。

项目成果

Long-term use of acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs and risk of hematologic malignancies: results from the prospective Vitamins and Lifestyle (VITAL) study.

长期使用对乙酰氨基酚、阿司匹林和其他非甾体抗炎药与血液恶性肿瘤的风险：前瞻性维生素和生活方式 (VITAL) 研究的结果。

• DOI: 10.1200/jco.2011.34.6346
• 发表时间: 2011-06-10
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: R. Walter;F. Milano;T. Brasky;E. White
• 通讯作者: E. White

Calcium intake and 10-year weight change in middle-aged adults.

中年人的钙摄入量和10年体重变化。

• 发表时间: 2006-07
• 作者: Gonzalez, Alejandro J;White, Emily;Kristal, Alan;Littman, Alyson J
• 通讯作者: Littman, Alyson J

Correlates of toenail zinc in a free-living U.S. population.

自由生活的美国人口中脚趾甲锌的相关性。

• 发表时间: 2008-01
• 影响因子: 5.6
• 作者: Gonzalez, Alejandro;Peters, Ulrike;Lampe, Johanna W;Satia, Jessie A;White, Emily
• 通讯作者: White, Emily

General and abdominal obesity and survival among young women with breast cancer.

患有乳腺癌的年轻女性的全身肥胖和腹部肥胖以及生存率。

• 发表时间: 2006-10
• 作者: Abrahamson, Page E;Gammon, Marilie D;Lund, Mary Jo;Flagg, Elaine W;Porter, Peggy L;Stevens, June;Swanson, Christine A;Brinton, Louise A;Eley, J William;Coates, Ralph J
• 通讯作者: Coates, Ralph J

Serum adiponectin, C-peptide and leptin and risk of symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial.

血清脂联素、C 肽和瘦素与症状性良性前列腺增生的风险：前列腺癌预防试验的结果。

• 发表时间: 2009-09-01
• 作者: Schenk, Jeannette M;Kristal, Alan R;Neuhouser, Marian L;Tangen, Catherine M;White, Emily;Lin, Daniel W;Thompson, Ian M
• 通讯作者: Thompson, Ian M