CENTER FOR RESEARCH IN REPRODUCTIVE PHYSIOLOGY

生殖生理学研究中心

• 批准号: 2196612
• 负责人: TONY M PLANT
• 金额: $ 62.25万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-29 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2196612
• 关键词: biomedical facility

The purpose of the Center for Research in Reproductive Physiology is to continue to investigate, using systematic physiological and contemporary cellular and molecular approaches, the control systems that govern major reproductive processes in mammals, with a special emphasis on higher primates. The Center, which has grown and diversified over the last 5 years of support, is currently comprised of 18 research projects subserved to varying degrees by 4 research core facilities: Primate (Core B), Assay (Core C), Histology (Core D) and Molecular Endocrinology (Core E). The Molecular Endocrinology Core, which was recently established by intramural funds, is now formally proposed for the first time. The research interests of the Center are wide ranging, extending, for example, from studies of the molecular mechanisms regulating steroid receptor action at the genomic level to investigation of the neuroendocrine control system governing gonadal function at the organismic level. Because of the established relevance to the human situation of data obtained from non-human primates, a major emphasis of the Center's research activity is focused on the analysis of reproductive control systems in the monkey. In this regard, the neuroendocrine regulation of testicular and ovarian function, the endocrine and paracrine regulation of ovarian and testicular function, the neurobiological basis of puberty, the impact of nutritional and metabolic parameters on the hypothalamic-pituitary-gonadal axis, the neural basis of the GnRH pulse generator, and the endocrine and neurochemical bases of sexual behavior are being systematically studied using the rhesus and cynomolgus monkey as experimental models. Several clinical studies of reproduction in men and women are also subserved by the Center. Significant areas of endeavor utilizing non-primate paradigms include studies of the regulation of gonadotropin subunit gene expression by gonadal steroids and peptides, the neurobiological basis of the inhibition of the GnRH pulse generator induced by suckling, the neuroendocrine control of the timing of the onset of puberty, and the anatomy of the neurocircuitry controlling hypothalamic releasing factor secretion. The Center is also committed to providing advanced training at the postdoctoral level in the physiological analysis of reproduction, integrating molecular, cellular and systems approaches. There is every reason to believe that this concentrated research approach to the study of reproductive physiology, in concert with a greatly expanded training program, will continue to have direct impact on the treatment of reproductive disorders in man.

生殖生理研究中心的目的是 继续使用系统的生理和现代研究 细胞和分子方法，主要控制主要的控制系统 哺乳动物的生殖过程，特别强调更高 灵长类动物。 该中心在过去的5个中已经成长和多元化 多年支持，目前由18个研究项目组成 在4个研究核心设施上，在不同程度上：灵长类动物（核心B），测定 （Core C），组织学（核心D）和分子内分泌学（核心E）。 这 分子内分泌核心，该核心最近通过壁内建立 现在是首次正式提出的资金。 研究兴趣 该中心的广泛范围，例如 调节类固醇受体作用在基因组上的分子机制 调查神经内分泌控制系统的水平 在有机水平上的性腺功能。 因为既定 与从非人类灵长类动物获得的数据的人类状况相关， 该中心研究活动的主要重点是 猴子中生殖控制系统的分析。 在这方面， 睾丸和卵巢功能的神经内分泌调节， 卵巢和睾丸功能的内分泌和旁分泌调节， 青春期的神经生物学基础，营养和代谢的影响 下丘脑 - 垂体 - 基达轴的参数，神经基础 GnRH脉冲发生器，以及内分泌和神经化学碱基 性行为正在使用恒河校系统地研究 cynomolgus猴子作为实验模型。 几项临床研究 中心也为男性和女性的繁殖也得到了补偿。 利用非青睐范式的重要领域包括 研究促性腺激素亚基基因表达的研究 性腺类固醇和肽，抑制的神经生物学基础 由哺乳引起的GNRH脉冲发生器的神经内分泌控制 青春期开始的时间和 控制下丘脑释放因子分泌的神经通路。 这 中心还致力于在博士后提供高级培训 繁殖生理分析的水平，整合分子， 细胞和系统方法。 有充分的理由相信 这种集中研究的研究方法 生理学与大大扩展的培训计划共同 继续对生殖疾病的治疗产生直接影响 在男人。