Mount Sinai HHEAR Network Untargeted Lab Hub

西奈山 HHEAR 网络非目标实验室中心

• 批准号: 10176494
• 负责人: Manish Arora
• 金额: $ 157.24万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176494
• 关键词: Address; Adolescence; Adult; Affect; Age; Analytical Chemistry; Archives; Automatic Data Processing; Behavioral; Biological; Biological Assay; Biological Markers; Blood; Cellular Structures; Charge; Chemical Exposure; Chemicals; Childhood; Chronic Disease; Client; Communication; Complex; Consultations; Creativeness; Data; Data Scientist; Data Set; Development; Developmental Biology; Disease; Dose; Ensure; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Risk Factor; Exposure to; Faculty; Funding; Genes; Genetic; Genomics; Goals; Grant; Growth; Hair; Health; Human; Institutes; Investments; Laboratories; Life; Life Cycle Stages; Link; Liquid substance; Longevity; Measures; Methodology; Methods; Mind; Mission; Modeling; Molecular; Molecular Biology; Nature; Neonatal; Occupations; Outcome; Pathogenicity; Pathway interactions; Phenotype; Physiological; Placenta; Plant Roots; Preparation; Procedures; Prospective cohort; Proteomics; Protocols documentation; Public Health; Research; Research Personnel; Resources; Sampling; Science; Services; Shipping; Speed; Spottings; Technology; Time; Tooth structure; Toxicokinetics; United States; United States National Institutes of Health; Work; base; case control; clinical practice; critical period; data centers; design; disability; disorder risk; environmental chemical; epidemiology study; fetal; flexibility; gene environment interaction; innovation; instrumentation; interest; lipidomics; mass spectrometer; medical schools; metabolomics; microbiome; microbiome research; microorganism; molecular dynamics; multidisciplinary; novel; novel marker; operation; prenatal; programs; response; sample collection; social; social stressor

PROJECT SUMMARY/ABSTRACT FOR OVERALL The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub (formerly known as “CHEAR” in grant cycle 1). We will use a suite of `omic' technologies to measure environmental exposures and their response across all life stages to help NIH funded researchers determine how the environment affects human health, development and risk of disease across the life span. In the last 3 years we have expanded our laboratory resources to include liquid handlers to automate sample prep/aliquoting and worked with data scientist to automate data processing to speed the pace of our jobs. In addition we doubled the number of mass spectrometers from 7 to 14 and hired additional faculty all in preparation for this renewal application. We will leverage our substantial institutional investments, including our new $30 million Institute for Exposomics, to serve the HHEAR Lab network and its NIH researcher clients. Our Untargeted Resource will use molecular enviromics and metabolomics to measure exposure to environmental chemicals and their metabolites as well as the internal response to those exposures. We will supplement those measures with metallomics, proteomics and lipidomics. However, we are cognizant of the ever-changing landscape of health research and have included Microbiome and Viromics to prempt the NIH funded researchers' interest in including these measures to existing studies. We have state-of- the-art analytical methodologies and instrumentation that were made available to CHEAR users. While we will continue to offer these well-established methods to HHEAR clients, we are also committed to listening to the needs of HHEAR users and develop new biomarkers to meet those needs. Our Developmental core will build upon its highly successful work in creating novel methods to measure current and past chemical exposures in novel biological matrices (e.g. teeth, hair, placenta, neonatal dry blood spots) and develop new assays that arise from HHEAR's targeted and environmental resources. Our Administrative Core will coordinate planning and communication internally among all Hub components and externally with the HHEAR Coordinating Center, Data Center and the other HHEAR Network Hubs. Internally, the Administrative Core will streamline and prioritize HHEAR jobs, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day-to-day operations. Our Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications and guide them to the most innovative environmental health science.

项目概要/总体摘要 西奈山伊坎医学院将利用我们在环境领域的研究专业知识 流行病学、分析化学和临床实践更新我们的人类健康暴露分析 资源 (HHEAR) 实验室网络中心（以前在资助周期 1 中称为“CHEAR”）。 一套“omic”技术，用于测量环境暴露及其在所有生命阶段的反应 帮助 NIH 资助的研究人员确定环境如何影响人类健康、发育和风险 在过去 3 年中，我们扩大了实验室资源，将液体纳入其中。 处理程序自动化样品准备/等分，并与数据科学家合作自动化数据处理 加快了我们的工作节奏。此外，我们将质谱仪的数量从 7 台增加到 14 台，并聘请了更多人员。 我们将利用我们庞大的机构来准备更多的教师。 投资，包括我们新的 3000 万美元的暴露组学研究所，为 HHEAR 实验室网络及其 NIH 研究人员客户我们的非目标资源将使用分子环境组学和代谢组学来测量 接触环境化学物质及其代谢物以及对这些物质的内部反应 我们将用金​​属组学、蛋白质组学和脂质组学来补充这些措施。 认识到健康研究不断变化的格局，并将微生物组和病毒组学纳入 抢占了美国国立卫生研究院资助的研究人员将这些措施纳入现有研究的兴趣。 我们将向 CHEAR 用户提供最先进的分析方法和仪器。 在继续为 HHEAR 客户提供这些行之有效的方法的同时，我们也致力于倾听 HHEAR 用户的需求并开发新的生物标志物来满足这些需求。 其在创建测量当前和过去化学品暴露的新方法方面取得了巨大成功 新颖的生物基质（例如牙齿、头发、胎盘、新生儿干血斑）并开发新的检测方法 来自 HHEAR 的目标资源和环境资源。我们的行政核心将协调规划。 所有 Hub 组件之间的内部通信以及与 HHEAR 协调中心的外部通信， 数据中心和其他 HHEAR 网络中心将在内部进行简化和管理。 确定 HHEAR 工作的优先顺序、评估检测需求、推广和传播新检测方法的开发， 我们的中心将协调协议和 QA/QC 程序并协调日常运营。 申请人了解样品要求、样品质量、结果解释、样品采集、储存协议 并提供运输规格样本，并指导他们了解最具创新性的环境健康科学。