Acquisition of a 900 MHz NMR Spectrometer Console and Probes

采购 900 MHz NMR 波谱仪控制台和探头

• 批准号: 10176998
• 负责人: ARTHUR G PALMER
• 金额: $ 173.22万
• 依托单位: NEW YORK STRUCTURAL BIOLOGY CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-03 至 2023-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176998
• 关键词: 14 year old; Complex; Funding; Generations; Institution; Magic; Minor; Modernization; NMR Spectroscopy; New York; Pathogenesis; Pharmacologic Substance; Research; Sampling; Services; Structure; System; United States National Institutes of Health; experimental study; instrumentation; novel lead compound; solid state nuclear magnetic resonance; structural biology

Funding is requested to obtain a Bruker Biospin NMR AVANCE Console and Probes to be installed on an existing Bruker Biospin 900 MHz NMR magnet system. The existing NMR console and probes are more than 14 years old and have reached the end of service lifetime, as designated by Bruker Biospin. The requested instrumentation provides enhanced sensitivity and capabilities for modern NMR experiments, including non-uniform sampling, complex waveform generation, and 1H magic- angle spinning solid-state NMR spectroscopy. The requested instrumentation is essential to the over- riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the particular aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 900 MHz NMR Spectrometer ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. The requested instrumentation will dramatically enhance the capacity of the 900 MHz NMR spectrometer to conduct this research.

需要资金来获得 Bruker Biospin NMR AVANCE 控制台和要安装的探头 在现有的 Bruker Biospin 900 MHz NMR 磁体系统上。现有的 NMR 控制台和探头 已使用 14 年以上且已达到布鲁克指定的使用寿命终点 生物纺丝。所需的仪器为现代仪器提供了增强的灵敏度和功能 NMR 实验，包括非均匀采样、复杂波形生成和 1H magic- 角旋转固态核磁共振波谱。所要求的仪器对于过度至关重要 纽约结构生物学中心 (NYSBC) 的骑行宗旨，该中心由九个研究机构组成 纽约州的机构，以支持 NIH 资助的主要研究的特定目标 以及光谱仪的次要用户。在 900 MHz 核磁共振波谱仪上进行的研究 范围从生物分子结构/功能的基础研究到机制的阐明 发病机制，发现新的药物应用先导化合物。这 所需的仪器将显着增强 900 MHz NMR 波谱仪的能力 进行这项研究。