Superhydrophobic Heart Valve Prosthesis

超疏水人工心脏瓣膜

• 批准号: 10181139
• 负责人: Lakshmi Prasad Dasi
• 金额: $ 68.94万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10181139
• 关键词: Address; Anticoagulation; Area; Artificial Heart; Biocompatible Materials; Biology; Biomechanics; Biomedical Engineering; Bioprosthesis device; Blood; Blood Platelets; Cardiovascular system; Catheters; Cells; Cessation of life; Characteristics; Clinical; Devices; Engineering; Environment; Freedom; Goals; Grant; Heart Valve Prosthesis; Heart Valves; Hemorrhage; Human; Image; In Vitro; Industry; Lead; Length; Leukocytes; Life; Liquid substance; Mechanics; Medical; Methods; Microfluidics; Operative Surgical Procedures; Patients; Performance; Pilot Projects; Plague; Platelet Activation; Polymers; Procedures; Research; Research Personnel; Risk; Saint Jude Children' s Research Hospital; Stents; Stress; Surface; Surgeon; Techniques; Technology; Testing; Thoracic Surgeon; Thromboembolism; Thrombus; Tissues; Training; Whole Blood; Work; base; biomaterial compatibility; blood damage; calcification; control theory; experience; experimental study; hemocompatibility; hemodynamics; immunogenic; implantation; improved; in vivo; in vivo Model; in vivo evaluation; indexing; innovation; left ventricular assist device; macrophage; materials science; member; minimally invasive; monocyte; nanoengineering; nanoscale; novel; pericardial sac; pyrolytic carbon; response; shear stress; thrombogenesis; valve replacement

Project Summary: All present day prosthetic heart valves suffer from complications. Mechanical heart valves (HVs) require life-long anti-coagulation therapy, while bioprosthetic heart valves based on fixed tissue are plagued with durability, immunogenic and calcification issues. Superhydrophobic (SH) bileaflet mechanical heart valves with vortex generator (VG) technology promise to eliminate the need for anti-coagulation therapy. Our lab has developed a SH bileaflet mechanical heart valve (BMHV) with VGs that drastically improve surface hemocompatibility as well as eliminate turbulent stresses, thus reducing platelet activation. Preliminary work has shown that SH surfaces remarkably reduced thrombogenic potential relative to plain pyrolytic carbon leaflets. Further, we have already demonstrated the feasibility of manufacturing BMHVs and assembling them with VGs into an implantable BMHV. The present R01 study aims to gauge the efficacy of SH BMHV with VG as a potential alternative to current heart valve technology by fine tuning material composition and processing to meet the durability and antithrombogenic requirements for heart valves. Our central hypothesis is: superhydrophobic BMHVs with vortex generator flow control technology will require significantly less anti-coagulation therapy. This is tested in three aims. Aim 1 focuses on elucidating the effects of leaflet composition and processing on hemocompatibility while optimizing the strength and hemocompatibility of the coating. Aim 2 quantifies heart valve hemodynamic performance of SH with VG BMHVs to identify the ideal SH+VG configuration for superior hemodynamics and minimum blood damage. Aim 3 focuses on understanding the in vivo hemocompatibility of SH with VG BMHV in a pilot ovine study. This proposal is led by Dr. Lakshmi Prasad Dasi, who is a well trained young investigator with expertise in heart valve engineering and cardiovascular biomechanics, and inventor of several heart valve technologies including VGs and novel biomolecule polymer leaflets. Multi-PIs are Dr. Kota, who is an established superhydrophobic materials expert; Dr. Popat whose expertise lies in bio-compatibility and surface nano-engineering. Co-Is include Dr. Brueur, Dr. Bark, Dr. Crestanello, Dr. Shinoka, and Dr. Hor who form an experienced team with expertise in in-vivo models, platelet biology, surgery, and imaging. If the proposed work demonstrates that SH with VG BMHVs do not require anti-coagulation, elicit excellent hemodynamics, and are durable, this R01 grant may lead to breakthrough technology for mechanical HVs that require little or no anticoagulation.

项目概要： 目前所有的人工心脏瓣膜都存在并发症。机械心脏瓣膜 (HV) 需要终生使用 抗凝治疗，而基于固定组织的生物假体心脏瓣膜则存在耐久性问题， 免疫原性和钙化问题。带涡流的超疏水 (SH) 双叶机械心脏瓣膜 发电机（VG）技术有望消除抗凝治疗的需要。我们实验室开发了一个 带 VG 的 SH 双叶机械心脏瓣膜 (BMHV) 也可显着改善表面血液相容性 消除湍流应力，从而减少血小板活化。初步工作表明SH表面 与普通热解碳小叶相比，显着降低了血栓形成的可能性。此外，我们已经 展示了制造 BMHV 并将其与 VG 组装成植入式 BMHV 的可行性。 目前的 R01 研究旨在评估 SH BMHV 与 VG 作为当前心脏的潜在替代品的功效 阀门技术通过微调材料成分和加工来满足耐用性和抗血栓形成的要求 对心脏瓣膜的要求。我们的中心假设是：带有涡流发生器的超疏水 BMHV 控制技术将需要显着减少的抗凝治疗。这是在三个目标上进行测试的。目标1 重点是阐明传单成分和加工对血液相容性的影响，同时进行优化 涂层的强度和血液相容性。目标 2 量化 SH 的心脏瓣膜血流动力学性能 与 VG BMHV 一起确定理想的 SH+VG 配置，以实现卓越的血流动力学和最少的血液 损害。目标 3 侧重于了解 SH 与 VG BMHV 在试验羊体内的血液相容性 学习。该提案由 Lakshmi Prasad Dasi 博士领导，他是一位训练有素的年轻研究员，在以下领域拥有专业知识： 心脏瓣膜工程和心血管生物力学，以及多项心脏瓣膜技术的发明者 包括 VG 和新型生物分子聚合物小叶。多位 PI 是 Kota 博士，他是一位知名人士 超疏水材料专家； Popat 博士的专长在于生物相容性和表面 纳米工程。 Co-Is 包括 Brueur 博士、Bark 博士、Crestanello 博士、Shinoka 博士和 Hor 博士，他们组成了一个 经验丰富的团队在体内模型、血小板生物学、手术和成像方面拥有专业知识。如果建议的工作 表明带有 VG BMHV 的 SH 不需要抗凝，可产生出色的血流动力学，并且 耐用，这项 R01 资助可能会带来机械 HV 的突破性技术，这些技术几乎不需要或不需要 抗凝。

项目成果

Zinc (Zn) Doping by Hydrothermal and Alkaline Heat-Treatment Methods on Titania Nanotube Arrays for Enhanced Antibacterial Activity.

通过水热和碱性热处理方法在二氧化钛纳米管阵列上掺杂锌 (Zn)，以增强抗菌活性。

• 发表时间: 2023-05-10
• 作者: Bhattacharjee, Abhishek;Goodall, Emma;Pereira, Bruno Leandro;Soares, Paulo;Popat, Ketul C
• 通讯作者: Popat, Ketul C

Hemp-Based Sustainable Slippery Surfaces: Icephobic and Antithrombotic Properties.

基于大麻的可持续光滑表面：疏冰和抗血栓特性。

• DOI: 10.1021/acssuschemeng.2c06233
• 发表时间: 2023-02-02
• 期刊: ACS sustainable chemistry & engineering
• 影响因子: 8.4
• 作者: Daniel J. Sutherl;A. M. Rather;R. Sabino;Sravanthi Vallabhuneni;Wei Wang;K. Popat;A. Kota
• 通讯作者: A. Kota

Improved Hemocompatibility on Superhemophobic Micro-Nano-Structured Titanium Surfaces.

改善超疏微纳米结构钛表面的血液相容性。

• 发表时间: 2022-12-29
• 作者: Manivasagam, Vignesh K;Popat, Ketul C
• 通讯作者: Popat, Ketul C

Designing Non-Textured, All-Solid, Slippery Hydrophilic Surfaces.

设计无纹理、全固体、光滑的亲水表面。

• DOI: 10.1016/j.matt.2022.09.024
• 发表时间: 2022-12-07
• 期刊: Matter
• 影响因子: 18.9
• 作者: Vahabi, Hamed;Vallabhuneni, Sravanthi;Hedayati, Mohammadhasan;Wang, Wei;Krapf, Diego;Kipper, Matt J.;Miljkovic, Nenad;Kota, Arun K.
• 通讯作者: Kota, Arun K.