BRAIN PEPTIDES IN CONTROL OF GONADOTROPIN AND PROLACTIN

控制促性腺激素和催乳素的脑肽

• 批准号: 2143396
• 负责人: SAMUEL M MCCANN
• 金额: $ 7.64万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2143396
• 关键词: GABA receptor; atrial natriuretic peptide; endocrine pharmacology; follicle stimulating hormone; gonadotropin releasing factor; gonadotropins; hormone regulation /control mechanism; hypothalamic pituitary axis; hypothalamus; interferons; interleukin 2; interneurons; laboratory rat; luteinizing hormone; melatonin; neurohypophyseal hormone; neuropeptides; organ culture; pituitary gland; prolactin; prolactin releasing /inhibiting factor; protein purification; secretion; thymosin

It is well accepted that hypothalamic control over the release of the anterior pituitary hormones is brought about by the release of peptidic releasing and inhibiting hormones into the hypophyseal portal vessels and five of these, namely thyrotropin-releasing hormone (TRH)l luteinizing hormone releasing-hormone (LHRH), growth hormone release inhibiting hormone (somatostatin, panhibin), corticotrophin-releasing factor (CRF), and growth hormone-releasing factor (GRF) have already been characterized and synthesized. The lactotrophs are at least under the partial inhibitory control of the monoamine, dopamine. There are a number of characterized prolactin-releasing factors (PRFs) which include oxytocin, vasoactive intestinal polypeptide, peptide histadine isoleucine, neurotensin, angiotensin II, and possibility substance P. At least two additional peptidic factors remain to be characterized, namely FSH-RF and peptidic prolactin (PRL) release inhibiting factor (PIF). It is the purpose of this grant to further evaluate the role of brain peptides, pituitary hormones, monokines and thymic peptides in the control of gonadotropin and PRL release by direct action on the gland and also to evaluate the role of brain peptides in the control of the release of the releasing and inhibiting hormones themselves. The studies can be divided into the following three principal areas: (1) role of peptides either alone or in combination with other modulating or releasing or inhibiting compounds in control of release of FSH, LH and PRL by direct action on the gland; (2) role of releasing and inhibiting hormones and pituitary hormones in modulating their own release and that of other releasing hormones from the hypothalamus; and (3) the role of peptides in controlling release of the releasing and inhibiting hormones.

人们普遍认为下丘脑控制释放 垂体前叶激素是由肽类物质的释放产生的 释放和抑制激素进入垂体门脉血管 其中五个，即促甲状腺素释放激素 (TRH)l 黄体生成素释放激素 (LHRH)、生长激素释放 抑制激素（生长抑素、泛西宾）、促肾上腺皮质激素释放 因子（CRF）和生长激素释放因子（GRF） 进行了表征和合成。泌乳素细胞至少低于 单胺、多巴胺的部分抑制控制。有一个 多种特征催乳素释放因子 (PRF)，其中包括 催产素、血管活性肠肽、肽组氨酸 异亮氨酸、神经降压素、血管紧张素 II 和可能的 P 物质。 至少还有两个其他肽因子有待表征，即 FSH-RF 和肽催乳素 (PRL) 释放抑制因子 (PIF)。 这笔赠款的目的是进一步评估大脑的作用 肽、垂体激素、单核因子和胸腺肽 通过直接作用于腺体来控制促性腺激素和 PRL 的释放 并评估脑肽在控制 释放激素和抑制激素本身的释放。研究 主要可分为以下三个方面：（1）作用 肽单独或与其他调节或组合 释放或抑制控制 FSH、LH 和 PRL 直接作用于腺体； (2)释放和抑制作用 激素和垂体激素调节自身释放 下丘脑释放的其他激素； (3) 的作用 肽在控制释放和抑制中的释放 荷尔蒙。