NIDDM AND OBESITY IN PIMA INDIANS--ROLE OF ENVIRONMENT

NIDDM 和 PIMA 印第安人肥胖——环境的作用

• 批准号: 2145188
• 负责人: LESLIE O SCHULZ
• 金额: $ 20.82万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2145188
• 关键词: Native Americans; bioenergetics; blood lipid; body composition; body physical characteristic; cardiovascular disorder; cholesterol; dietary constituent; disease /disorder proneness /risk; genetic markers; glucose tolerance test; hemoglobin As; human ecology; human genetic material tag; human subject; insulin; lifestyle; metabolism disorder diagnosis; noninsulin dependent diabetes mellitus; nutrition related tag; obesity; questionnaires; restriction fragment length polymorphism; statistics /biometry; urinalysis

Our goal is to identify the importance of environmental factors to the development of non-insulin dependent diabetes mellitus (NIDDM) and obesity in Pima Indians. We propose to compare Pimas living in Arizona in an affluent environment (data already available) to Pimas living under markedly contrasting conditions in a remote, mountainous region of Northwest Mexico. Also, the comparison of Pima and non-Pima Mexicans will provide further information on two groups genetically unrelated but living in the same environment. The Pimas of Arizona have the highest reported prevalences of NIDDM and obesity. They have been the focus of intensive investigation and a great deal is known about their history. The Arizona Pimas and their ancestors were skilled farmers with extensive knowledge of irrigation, using the water of the Gila River to cover their food needs. At the turn of the century, water became scarce due to diversion upstream by White settlers. The Pimas were forced to curtail farming and experienced a dramatic change in lifestyle which impacted both food intake and physical activity. Subsequently, chronic medical problems such as diabetes and obesity developed. Our preliminary studies of Pimas living in an undeveloped environment in Northwest Mexico indicate their lifestyle is characterized by greater energy expenditure in physical labor and a traditional Mexican diet. We found significant differences between Mexican and Arizona Pimas with respect to body mass index, body composition, and serum cholesterol. In addition, preliminary results suggest NIDDM is less prevalent in the Mexican Pimas. Therefore, we propose to perform measurements of glucose tolerance, hemoglobin A(1c), insulin, and anthropometrics. The genetic distance between Pimas of Mexico and Arizona will be assessed using DNA typing. Lifestyle factors (diet and physical activity), energy metabolism (resting metabolic rate and total energy expenditure), and cardiovascular disease risk factors will be examined as possible determinants of differences observed between the two groups of Mexicans and the Arizona Pimas with respect to the prevalence and complications of NIDDM and obesity. These data will contribute important information regarding the impact of environment on the pathogenesis of NIDDM and obesity.

我们的目标是确定环境因素对 非胰岛素依赖性糖尿病（NIDDM）和肥胖症的发展 在皮玛印第安人。 我们建议比较生活在亚利桑那州的皮马斯 富裕的环境（已经可用的数据） 在一个偏远，山区的区域明显对比 西北墨西哥。此外，PIMA和非PIMA墨西哥人的比较将 提供有关两组基因无关但活着的进一步信息 在同一环境中。 亚利桑那州的PIMA的NIDDM的患病率最高 肥胖。他们一直是密集调查的重点，而且很棒 交易已经知道他们的历史。亚利桑那Pimas及其祖先 是熟练的农民，使用了广泛了解灌溉的知识 吉拉河的水以满足他们的食物需求。在 世纪，由于白人定居者上游的转移，水变得稀缺。 Pimas被迫减少耕种并经历了巨大的改变 在生活方式中影响了食物摄入和体育锻炼。 随后，诸如糖尿病和肥胖等慢性医学问题 发达。 我们对生活在未开发环境中的Pimas的初步研究 墨西哥西北部表明他们的生活方式的特征是更大 体力劳动和传统墨西哥饮食的能源消耗。我们 发现墨西哥和亚利桑那PIMA之间有显着差异 尊重体重指数，身体成分和血清胆固醇。在 此外，初步结果表明NIDDM在 墨西哥皮马。因此，我们建议对葡萄糖进行测量 耐受性，血红蛋白A（1C），胰岛素和人类测量法。遗传 将使用DNA评估墨西哥和亚利桑那PIMA之间的距离 打字。生活方式因素（饮食和体育锻炼），能量代谢 （静息代谢率和总能量消耗）和心血管 将检查疾病危险因素作为可能的决定因素 两组墨西哥人和亚利桑那州之间观察到的差异 关于NIDDM的患病率和并发症的PIMA和 肥胖。这些数据将为有关 环境对NIDDM和肥胖症的发病机理的影响。