Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

产生 NIDA 机会的群体合作联盟 (C3PNO)

基本信息

批准号：
10165380
负责人：
Pamina Mae Gorbach
金额：
$ 32.61万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10165380
关键词：
2019-nCoV AIDS prevention Address Adherence Administrative Supplement Adolescent Medicine Trials Network Affect Alcohol or Other Drugs use Anxiety Appointment Area Baltimore Behavior COVID-19 COVID-19 pandemic Cannabis Caring Chicago Cities Cohort Studies Collection Communities Continuity of Patient Care Counseling Data Drug usage Family Food Frequencies Funding Funding Opportunities HIV HIV Infections HIV Seronegativity HIV Seropositivity HIV prevention trials network Health Height Home environment Housing Individual Infrastructure Injections Interruption Link Los Angeles Measures Medical Records Mental Health Methamphetamine NIH Program Announcements National Institute of Drug Abuse North America Opioid Participant Patient Self-Report Pharmaceutical Preparations Population Population Group Prevalence Prevention Research Risk Factors Science Smoking Social isolation Specific qualifier value Substance Use Disorder Surveys Time Tobacco Vulnerable Populations addiction antiretroviral therapy base cohort data harmonization design experience food insecurity frontier high risk innovation interest intimate partner violence marijuana vaping neurodevelopment novel opioid use disorder pre-exposure prophylaxis prescription opioid public health emergency response social stimulant use vaping young men who have sex with men

项目摘要

ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO; U24DA044554) proposes a project to assess the impact of COVID-19 on the participating cohorts' population of substance-using people living with HIV (PLWH) and those at high-risk for HIV infection. Our innovative study proposes to collect data from a subset of participants from each of seven participating C3PNO cohorts at two time points – in the height of the COVID-19 pandemic and during its mitigation and control – in order to assess the impact of the COVID-19 epidemic on substance use for PLWH and those at high risk for HIV. We will use our current infrastructure and C3PNO validated harmonization strategies to compile new and existing data across the cohorts in order to: assess changes in social and individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic as compared to other HIV studies and cohorts that have less substance use. The C3PNO Coordinating Center at UCLA and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset of participants from each of seven participating C3PNO cohorts (ALIVE, HYM, JHHCC, MASH, mSTUDY, RADAR, and V-DUS). Participating cohorts will issue the survey to participants and transfer the resulting data to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency affecting the highly vulnerable substance-using populations followed by the cohorts. COVID-19 data harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19 on HIV impacted communities. Finally, C3PNO's effort to assess changes in social and individual determinants of health during the course of the COVID-19 pandemic as well as estimate differences in substance-using behaviors and the impact on PLWH or at high risk for HIV is both novel and critical in this time of unprecedented social upheaval and instability.

抽象的响应关于行政补充和行政补充的可用性的特别利益通知 (NOSI) 2019 年新型冠状病毒研究紧急竞争性修订（通知编号 NOT-DA-20-047 和链接的计划公告 PA-18-591）资助机会，队列合作联盟 Production NIDA Opportunities（C3PNO；U24DA044554）提出了一个评估 COVID-19 影响的项目关于参与队列的吸毒艾滋病毒感染者 (PLWH) 人群和高危人群我们的创新研究建议是从七名参与者中的每一个参与者中收集数据。在两个时间点参与的 C3PNO 队列：在 COVID-19 大流行最严重的时期和在其流行期间缓解和控制——以评估 COVID-19 流行病对 PLWH 物质使用的影响我们将使用我们现有的基础设施和经过 C3PNO 验证的协调。跨群体编译新数据和现有数据的策略，以便：评估社会和 COVID-19 大流行期间的个体健康决定因素，以估计 COVID-19 确诊/疑似病例的物质使用行为（基于自我报告或病历）和非确诊/疑似病例，并评估感染者和疑似病例的情况 C3PNO 中的 HIV 感染高危人群在 COVID-19 流行病方面有不同的经历和应对措施，与药物使用较少的其他 HIV 研究和队列相比。加州大学洛杉矶分校和前沿科学将促进一项调查的设计和实施，以从子集中收集数据来自七个参与 C3PNO 队列（ALIVE、HYM、JHHCC、MASH、mSTUDY、 RADAR 和 V-DUS）参与队列将向参与者发布调查并传输结果数据。如果得到资助，这一行政补充将能够实现快速、协调的工作。收集与持续发生的公共卫生紧急情况相关的 COVID-19、HIV 和药物使用相关数据影响高度脆弱的物质使用人群，其次是 COVID-19 数据。与其他 HIV 群体的协调将进一步帮助我们共同努力了解 COVID-19 的影响最后，C3PNO 努力评估社会和个人决定因素的变化。 COVID-19 大流行期间的健康状况以及估计物质使用的差异在这个前所未有的时期，行为及其对艾滋病病毒感染者或艾滋病毒高危人群的影响既新颖又至关重要社会动荡和不稳定。