Reproductive Development from Gonads to Fetuses

从性腺到胎儿的生殖发育

• 批准号: 10163223
• 负责人: Kyle Edwin Orwig
• 金额: $ 16.33万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-09 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10163223
• 关键词: Fetus; gonad development; reproductive development

PROJECT SUMMARY/ABSTRACT Discoveries in reproductive biology have had a remarkable impact in science and medicine, leading to several Nobel prizes in Physiology or Medicine in the past decade. Despite these advances in science that were produced by experts in the reproductive biology, the number of reproductive science trainees is dwindling at an alarming rate. To help reverse this trend, we have established this T32 Training Program in Reproductive Development from Gonads to Fetuses (RDGF). The purpose of this program is to tap the large, diverse and highly qualified pipeline of graduate students (PhD or MD/PhD) and postdoctoral fellows (MD or PhD) that matriculate at the University of Pittsburgh each year and recruit them to pursue training and careers in the reproductive sciences. This training program will enhance the recruitment of reproductive biology researchers into the unique environment at Magee-Womens Research Institute where graduate students, postdoctoral fellows, medical residents, medical fellows and junior faculty (119 total trainees) work side by side in state of the art research facilities and experience on a daily basis how fundamental research discoveries impact reproductive medicine and patient care. The overarching objectives of the Program are to select and recruit the most qualified candidates (3 PhD students and 3 postdocs/year) into the reproductive sciences and pair them with well-funded, productive mentors who are committed to the training mission of the program and the University of Pittsburgh/Magee. The program will provide trainees with the education, resources and technical experience to conduct impactful science, while adhering to the principles of responsible conduct of research and scientific integrity. Rigorous oversight and progress review of Trainee/Mentor teams will ensure that trainees are fully immersed in all aspects of academic career development, including career development coursework, publications, grant submissions and attendance/presentation at local and national/international meetings. Research productivity milestones (e.g., publications, grants and awards) combined with connections made in the reproductive biology community at meetings will set the stage for advancement to the next stage of career development. Full immersion of trainees in all aspects of their academic endeavors will endow them with a sense of ownership of their research productivity and increase the likelihood that they will be retained long-term in reproductive science-related careers. Graduate students (PhD or MD/PhD) can remain in the training program for a maximum of five years and postdoctoral fellows can remain in the program for a maximum of three years. However, our program requires that all trainees write and submit and individual training grant application during their second year of training. This is a valuable skill for a career in science and the turnover as trainees transition from institutional to individual awards will help maximize the number of trainees and impact of the program. We anticipate training a total of 6 graduate students and 6 postdoctoral trainees during the five year award period.

项目概要/摘要 生殖生物学的发现对科学和医学产生了显着的影响，导致了一些 过去十年的诺贝尔生理学或医学奖。尽管科学取得了这些进步 由生殖生物学专家制作的生殖科学实习生人数正在急剧减少 速度惊人。为了帮助扭转这一趋势，我们制定了 T32 生殖培训计划 从性腺到胎儿的发育（RDGF）。该计划的目的是挖掘大规模、多样化和 高素质的研究生（博士或医学博士/博士）和博士后研究员（医学博士或博士）管道 每年都会被匹兹堡大学录取，并招募他们在该大学接受培训和职业生涯 生殖科学。该培训计划将加强生殖生物学研究人员的招募 进入 Magee-Women Research Institute 的独特环境，那里有研究生、博士后 研究员、住院医生、研究员和初级教员（总共 119 名学员）并肩工作 艺术研究设施和日常经验基础研究发现如何影响 生殖医学和患者护理。该计划的总体目标是选拔和招募 最有资格的候选人（每年 3 名博士生和 3 名博士后）进入生殖科学领域并结对 他们拥有资金充足、富有成效的导师，他们致力于该计划的培训使命和 匹兹堡大学/马吉。该计划将为学员提供教育、资源和技术 具有开展有影响力的科学研究的经验，同时坚持负责任的研究行为原则 和科学诚信。对实习生/导师团队的严格监督和进度审查将确保 学员完全沉浸在学术职业发展的各个方面，包括职业发展 课程作业、出版物、赠款申请以及在当地和国家/国际上的出席/演讲 会议。研究生产力里程碑（例如出版物、资助和奖励）与联系相结合 生殖生物学界在会议上提出的意见将为下一阶段的推进奠定基础 的职业发展。学员充分沉浸在学术努力的各个方面将使他们 对自己的研究成果有主人翁意识，并增加他们被保留的可能性 长期从事生殖科学相关职业。研究生（博士或医学博士/博士）可以留在 培训计划最长五年，博士后研究员可以在该计划中保留一段时间 最长三年。然而，我们的计划要求所有学员撰写并提交个人资料 在培训的第二年申请培训补助金。对于科学事业来说这是一项宝贵的技能 随着学员从机构奖项过渡到个人奖项，人员流动率将有助于最大限度地提高获奖人数 受训者和该计划的影响。预计共培养研究生6名，博士后6名 五年奖励期内的受训人员。

项目成果

Tiny Dancer: EFCAB9 Triggers Sperm Hyperactivation via CatSper.

小舞者：EFCAB9 通过 CatSper 触发精子过度激活。

• DOI: 10.1016/j.tibs.2019.08.001
• 发表时间: 2019-10-01
• 期刊: Trends in biochemical sciences
• 影响因子: 13.8
• 作者: Rachel E. Bainbridge;Anne E. Carlson
• 通讯作者: Anne E. Carlson

Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole.

研究药物代谢酶在达匹韦林和咪康唑药物相互作用中的作用。

• 发表时间: 2021-12-18
• 影响因子: 5.4
• 作者: Valicherla, Guru Raghavendra;Graebing, Phillip;Zhang, Junmei;Zheng, Ruohui;Nuttall, Jeremy;Silvera, Peter;Rohan, Lisa Cencia
• 通讯作者: Rohan, Lisa Cencia

Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals.

锌对受精卵的保护是动物有性生殖的一个古老特征。

• 发表时间: 2020-07
• 影响因子: 9.8
• 作者: Wozniak, Katherine L;Bainbridge, Rachel E;Summerville, Dominique W;Tembo, Maiwase;Phelps, Wesley A;Sauer, Monica L;Wisner, Bennett W;Czekalski, Madelyn E;Pasumarthy, Srikavya;Hanson, Meghan L;Linderman, Melania B;Luu, Catherine H;Boehm, Madiso
• 通讯作者: Boehm, Madiso

Testicular tissue cryopreservation: 8 years of experience from a coordinated network of academic centers.

睾丸组织冷冻保存：来自学术中心协调网络的 8 年经验。

• 发表时间: 2019-06-04
• 作者: Valli;Peters, K A;Gassei, K;Steimer, S R;Sukhwani, M;Hermann, B P;Dwomor, L;David, S;Fayomi, A P;Munyoki, S K;Chu, T;Chaudhry, R;Cannon, G M;Fox, P J;Jaffe, T M;Sanfilippo, J S;Menke, M N;Lunenfeld, E;Abofoul;Sender
• 通讯作者: Sender

Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions.

达匹韦林的转运和渗透特性：了解潜在的药物相互作用。

• 发表时间: 2022-09-14
• 影响因子: 5.4
• 作者: Zheng, Ruohui;Valicherla, Guru R;Zhang, Junmei;Nuttall, Jeremy;Silvera, Peter;Marshall, Leslie J;Empey, Philip E;Rohan, Lisa C
• 通讯作者: Rohan, Lisa C