SCOR--LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

SCOR--婴儿和儿童的肺生物学和疾病

• 批准号: 2218192
• 负责人: ROBERT H NOTTER
• 金额: $ 118.83万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-12-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2218192
• 关键词: child (0-11); infant human (0-1 year); lung injury; pulmonary surfactants; respiratory disorder

This is a renewal application for a Specialized Center of Research (SCOR) for Lung Biology and Disease in Infants and Children. The proposal is comprised of a series of fundamental studies aimed at understanding the cellular and molecular aspects of lung injury, growth and development, and these are then coupled with direct clinical studies developing and optimizing therapies for related respiratory disorders in infants. a strong emphasis is placed on pulmonary surfactant-related phenomena in the proposed research, but major effort is also aimed at analyzing and describing a range of cellular, biochemical, and physiological phenomena important in lung disease, injury and development. These objectives are addressed in this SCOR proposal through the following complementary studies: 1) cell and molecular biological studies of growth factors and cytokines from macrophages and other cells, and their effects on type II cells and fibroblasts in normal and injured lungs; 2) molecular biological studies involving specific molecules (TIMP, metallothionein, etc.) whose gene expression and production is altered in lung injury from hyperoxia, fatty acid administration, and other causes, and the regulation and roles of these materials in the injury process; 3) physicochemical studies of the surface activity, component interactions, and biophysical inhibition of natural and synthetic lung surfactants, and the ramifications of these phenomena for the pathophysiology and therapy of lung disease and injury; 4) mechanistic studies of the cell biology, biochemistry, and physiology of acute lung injury in animal models (hyperoxia, barotrauma and surfactant- deficiency, or oleic acid and meconium administration) and how these conditions can be treated with exogenous surfactants, anti-oxidant enzymes, and steroid hormones; and 5) a series of clinical studies involving surfactant replacement and other therapies including jet ventilation for the neonatal Respiratory Distress Syndrome and for neonatal lung injury secondary to pneumonia and meconium aspiration. These inter-related basic science and clinical studies continue and extend our current SCOR research, and are carried out by a multi-disciplinary group of investigators with a history of productive scientific collaboration.

这是专业研究中心 (SCOR) 的续展申请 婴儿和儿童的肺部生物学和疾病。 该提案是 由一系列基础研究组成，旨在了解 肺损伤、生长和发育的细胞和分子方面，以及 然后将这些与直接的临床研究相结合 优化婴儿相关呼吸系统疾病的治疗。 一个 重点关注肺表面活性物质相关现象 拟议的研究，但主要努力还旨在分析和 描述一系列细胞、生化和生理现象 在肺部疾病、损伤和发育中发挥重要作用。 这些目标是 本 SCOR 提案通过以下补充内容予以解决 研究：1）生长因子和细胞和分子生物学研究 来自巨噬细胞和其他细胞的细胞因子及其对 II 型细胞的影响 正常和受损肺部的细胞和成纤维细胞； 2）分子生物学 涉及特定分子（TIMP、金属硫蛋白等）的研究 高氧引起的肺损伤中基因表达和产生发生改变， 脂肪酸的施用、其他原因以及调节和作用 这些材料在损伤过程中的作用； 3）物理化学研究 表面活性、成分相互作用和生物物理抑制 天然和合成的肺表面活性剂，以及这些的后果 肺部疾病和损伤的病理生理学和治疗现象； 4）细胞生物学、生物化学和生理学的机制研究 动物模型中的急性肺损伤（高氧、气压伤和表面活性剂- 缺乏，或油酸和胎便管理）以及这些如何 可以用外源性表面活性剂、抗氧化酶、 和类固醇激素； 5）一系列临床研究涉及 表面活性剂替代疗法和其他疗法，包括喷射通气 新生儿呼吸窘迫综合征和新生儿肺损伤 继发于肺炎和胎便吸入。 这些相互关联的基本 科学和临床研究继续并扩展我们当前的 SCOR 研究， 并由多学科研究人员小组进行 富有成效的科学合作的历史。