SCOR--LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

SCOR--婴儿和儿童的肺生物学和疾病

• 批准号: 2222955
• 负责人: PHILIP M FARRELL
• 金额: $ 74.11万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2222955
• 关键词: bronchopulmonary dysplasia; child (0-11); human subject; premature infant human; respiratory distress syndrome of newborn

The UW-Madison Specialized Center of Research on "Lung Biology and Disease in Infants and Children" will be devoted to elucidation of the pathobiology of bronchopulmonary dysplasia (BPD), particularly the delineation of cellular and biochemical mechanisms potentially important in either the pathogenesis of neonatal lung injury or the repair processes that facilitate recovery from chronic respiratory insufficiency of infants. This mission will be addressed in a multidisciplinary research program featuring a combination of interrelated basic and clinical investigations designed to expedite the development and application of new knowledge that might improve our understanding and treatment of bronchopulmonary dysplasia. There will be four research projects entitled: 1. Assessment of the role of oxyradicals in the pathogenesis of BPD. 2. Retinol function in the pathogenesis and repair of BPD. 3. Calcium-dependent phospholipid-binding proteins as related to lung development, RDS, and BPD. 4. Effect of hyperoxia on alveolar type II cell proliferation and differentiation during neonatal lung growth. These investigation, will be facilitated by three core units providing: a) administrative services; b) biostatistics/computing resources and assistance; and c) research coordinating support.

UW-Madison的专业研究中心“肺部生物学与疾病 在婴儿和儿童中”将致力于阐明病理生物学 支气管肺发育不良（BPD），特别是描述 细胞和生化机制在任何一种中可能很重要 新生儿肺损伤或修复过程的发病机理 促进婴儿慢性呼吸不足的恢复。 该任务将在多学科研究计划中解决 结合了相互关联的基本和临床研究 旨在加快新知识的发展和应用 可能会改善我们对支气管肺的理解和治疗 发育不良。 将有四个题为： 1。评估草自由基在BPD发病机理中的作用。 2。视黄醇在BPD的发病机理和修复中的功能。 3。与肺有关的钙依赖性磷脂结合蛋白 开发，RD和BPD。 4。高氧对肺泡II型细胞增殖的影响和 新生儿肺生长期间的分化。 这些调查将由提供的三个核心单位促进：a） 行政服务； b）生物统计学/计算资源和 协助; c）研究协调支持。