BIOLOGY OF CHILDHOOD NEPHROTIC SYNDROME

儿童肾病综合征的生物学

• 批准号: 2144025
• 负责人: IEKUNI ICHIKAWA
• 金额: $ 60.02万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2144025
• 关键词: nephrotic syndrome

All seven participating investigators within this Pediatric Nephrology Division have had a long-standing interest in delineating the pathogenic/pathophysiologic mechanisms underlying impaired glomerular function and structure in a variety of nephrologic and urologic diseases. The new findings stemming from these studies were integrated with work done by others in producing several comprehensive reviews discussing the contemporary view of pathophysiology of each type of renal failure, namely, pre-renal, renal, post-renal failures as well as chronic renal failure. Critical assessment of our current knowledge of the pathogenic/ pathophysiologic processes has led us to believe that to attain the next level of understanding these processes require application of the newest biochemical and molecular biological technologies. It is with this in mind that each of the participants has become engaged in collaboration with experts in the forefront of basic sciences. It is fortunate that Vanderbilt has both the talent and unique atmosphere where such associations are encouraged. In response to the call for "Pediatric Nephrology and Urology Center Grant" application, we decided to integrate the existing talent, knowledge and skills acquired through these collaborations to pursue in depth one selected area. We have chosen childhood nephrotic syndrome in view not only of the magnitude of this problem in clinical pediatrics, but also because of its direct relevance to ongoing research by these investigators. Since this problem appears closely linked to maturational development, the study of glomerular maturation has also been integrated as an important part of our goals.

该小儿肾脏病中的所有七个参与调查员 部门对描述 致病/病理生理机制受损的肾小球 各种肾病和泌尿科疾病的功能和结构。 这些研究的新发现与完成的工作结合了 其他人在制作了几项综合评论中讨论 每种肾衰竭的病理生理学的当代观点，即 肾上部，肾脏后，肾上腺失败以及慢性肾衰竭。 批判性评估我们当前对病原/的知识 病理生理过程使我们相信要达到下一个 理解这些过程需要应用最新的过程 生化和分子生物学技术。 这是考虑到这一点 每个参与者都与 基础科学最前沿的专家。 幸运的是 范德比尔特（Vanderbilt）既有才华和独特的氛围 鼓励协会。 回应呼吁“小儿 肾脏学和泌尿外科中心赠款“应用，我们决定整合 通过这些获得的现有人才，知识和技能 协作以深入一个选定区域。 我们选择了 儿童期肾病综合征不仅认为这一点 临床儿科的问题，也是因为它与 这些研究者正在进行的研究。 由于这个问题出现 肾小球的研究与成熟发展密切相关 成熟也已作为我们目标的重要组成部分。