Administrative Core

行政核心

基本信息

批准号：
10162824
负责人：
SCOTT J. HULTGREN
金额：
$ 4.72万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10162824
关键词：
Affinity Antibiotic Resistance Antibiotics Area Attention Bacteria Bacterial Adhesins Bacterial Antibiotic Resistance Bacterial Infections Basic Science Budgets COVID-19 Cellular biology Centers for Disease Control and Prevention (U.S.)Clinical Collaborations Combating Antibiotic Resistant Bacteria Communication Communication Methods Development Doctor of Philosophy Electronic Mail Ensure Fostering Funding Goals Grant Guidelines Health Human Immunology Infection Institution Interdisciplinary Study International Journals Leadership Ligands Medicine Membrane Methodology Microbiology Monitor Monoclonal Antibodies Multi-Drug Resistance Nosocomial Infections Pathogenicity Peer Review Persons Pharmaceutical Chemistry Physiology Program Evaluation Progress Reports Publications Regulation Research Research Personnel Research Project Grants Resource Sharing Schedule Scientist Series Site Visit Teleconferences Therapeutic Translating Translations United States United States National Institutes of Health Wages antibiotic resistant infections combat data exchange design improved functioning individual responsibility innovation meetings member mimetics pathogen pathogenic bacteria prevent product development programs response small molecule inhibitor success therapeutic development

项目摘要

PROJECT SUMMARY/ ABSTRACT: COVID-19 exemplifies the dire consequences of being unprepared for the next health crisis. One looming crisis involves the insidious rise of antibiotic resistant bacterial infections, necessitating the research described in our U19 application entitled “Innovative strategies to combat antibiotic-resistant infections” in response to RFA-AI-20-001 (Combating Antibiotic-resistant Bacteria Interdisciplinary Research Units (CARBIRU)). Our proposal is leveraged to translate basic science into new types of antibiotic-sparing medicines for common infections in the United States as well as common hospital-acquired infections. This U19 application utilizes a multi-departmental, multi-institutional, and interdisciplinary group of highly motivated microbiology, cell biology/physiology, immunology and medicinal chemistry researchers to develop antibiotic-sparing therapeutics and compounds that are capable of: i) treating common infections; and/or ii) increasing sensitivity to the current arsenal of available antibiotics. The Administrative Core (AC) will be responsible for coordinating the activities and monitoring the progress of the three research projects and the two scientific cores to achieve the overall goals of the U19 program. To accomplish this, the AC Leader, with the help of an Executive Committee comprising of the Leaders of the Research Projects and Cores, will oversee and coordinate the activities of the members of the Projects and Cores by: i) fostering frequent interactions; ii) supporting the exchange of data, methodologies, and ideas; iii) facilitating interactions with institutional and outside experts to gain advice for better functioning of the overall program and for translation of the program's findings into therapeutics development; and iv) coordinating financial and scientific progress reporting to granting agency staff. In addition, the AC will coordinate active participation in the U19 to ensure its overall success.

项目概要/摘要： COVID-19 体现了对下一场迫在眉睫的健康危机未做好准备所带来的可怕后果。涉及抗生素耐药性细菌感染的隐秘增加，因此需要我们进行研究 U19申请题为“对抗抗生素耐药性感染的创新策略” RFA-AI-20-001（对抗抗生素耐药细菌跨学科研究单位 (CARBIRU)）。我们的建议旨在将基础科学转化为常见的新型抗生素节约药物该 U19 应用程序使用了美国的感染以及常见的医院获得性感染。多部门、多机构、跨学科的微生物学、细胞学研究小组生物学/生理学、免疫学和药物化学研究人员开发抗生素节约型能够：i) 治疗常见感染和/或 ii) 增加敏感性的治疗剂和化合物；行政核心 (AC) 将负责协调现有的抗生素。三个研究项目和两个科学核心的活动并监测进展情况，以实现为了实现这一目标，AC 领导在执行人员的帮助下。由研究项目和核心领导者组成的委员会将监督和协调项目和核心成员的活动： i) 促进频繁的互动； ii) 支持交流数据、方法和想法； iii) 促进与机构和外部专家的互动获得建议，以更好地发挥整个计划的作用，并将计划的结果转化为疗法开发；和 iv) 协调向资助机构报告财务和科学进展此外，AC 将协调 U19 的积极参与，以确保其整体成功。