BoostOne

升压一

基本信息

批准号：
10158895
负责人：
Salil Patel
金额：
$ 24.56万
依托单位：
NXTECH INC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10158895
关键词：
Acute Address Adherence Affect Animal Model Attention Cellular Phone Client Clinic Clinical Cognitive Computer software Counseling Cues Custom Data Decision Making Disease Drug usage Educational Intervention Engineering Event Executive Dysfunction Exercise Face Feasibility Studies Formularies Foundations Goals Government Hyperactivity Impairment Impulsivity Incentives Individual Insurance Carriers Intervention Learning Letters Licensing Measurement Measures Medical Memory Modeling Motivation Neurobiology Outcome Outcome Measure Outpatients Participant Pathway interactions Patients Periodicity Persons Pharmaceutical Preparations Phase Population Prevention strategy Process Psychometrics Public Health Recovery Relapse Research Resources Sales Self Perception Self-control as a personality trait Series Short-Term Memory Signal Transduction Small Business Innovation Research Grant Social Environment Societies System Technology Test Result Testing Therapeutic Time Time Perception Traction Training Treatment Efficacy Treatment Protocols Treatment outcome Urine Validation Vision Visit active method base cloud software cost craving design digital directed attention disorder later incidence prevention distraction efficacy evaluation executive function experience improved innovation mindfulness neurobehavioral non-opioid analgesic novel opioid therapy opioid use disorder opioid user patient engagement peer support primary outcome psychologic quality assurance relating to nervous system response satisfaction smartphone Application successful intervention tool uptake usability

项目摘要

PROJECT SUMMARY Individuals with opioid user disorder (OUD) face both short-term and long-horizon challenges to healthy and productive decision-making. Recovery, particularly in the setting of MAT (but also more generally), is deeply affected by phasic/psychological cravings and impaired long-horizon decision-making. Current cravings- avoidance tools suffer from limited usability and restricted utility in common environmental/social contexts. In addition, the majority of introspective or self-control improvement strategies (mindfulness, CBT) are unsuited for uptake during moments of vulnerability, while clinical counseling or peer support suffer from scale/access limitations. In response, we propose a field-deployable (mobile smartphone), automated intervention for acute cravings in OUD which simultaneously addresses neurobiological drivers of long-term impulsive decision- making. The innovation (“BoostONE”) comprises a system for just-in-time cravings management (Boost-C) and impulsivity mitigation (Boost-I) and includes a framework for psychometric measurement of executive function for outcomes tracking. Predicted effects of usage by individuals in MAT will be evaluated in a feasibility study of the validated package. We anticipate this Phase I SBIR will provide the foundation for deployment of BoostONE in active treatment settings and for broader extensions of the underlying technology framework.

项目概要患有阿片类药物使用障碍 (OUD) 的个体在健康和健康方面面临着短期和长期的挑战。有效的决策制定，特别是在 MAT 环境中（但也更普遍），是深刻的。受到阶段性/心理渴望和当前渴望受损的长期决策的影响。在共同的环境/社会背景下，回避工具的可用性和效用受到限制。此外，大多数内省或自我控制改进策略（正念、CBT）都不适合在脆弱时刻接受，而临床咨询或同伴支持则受到规模/访问的影响作为回应，我们提出了一种可现场部署（移动智能手机）的自动化干预措施。对 OUD 的渴望，同时解决长期冲动决策的神经生物学驱动因素该创新（“BoostONE”）包括即时渴望管理系统（Boost-C）和冲动缓解（Boost-I），并包括执行功能的心理测量框架结果跟踪。个人使用 MAT 的预测效果将在可行性研究中进行评估。我们预计第一阶段 SBIR 将为 BoostONE 的部署奠定基础。积极的治疗环境和更广泛的基础技术框架的扩展。