Stephenson Cancer Center - Cancer Center Support Grant

史蒂芬森癌症中心 - 癌症中心支持补助金

基本信息

批准号：
10161020
负责人：
ROBERT S. MANNEL
金额：
$ 92.98万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10161020
关键词：
Address American Indians Benchmarking Biometry Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Catchment Area Clinical Clinical Data Clinical Protocols Clinical Trials Cytometry Data Development Diagnosis Direct Costs Disease Education Enrollment Environment Environment Design Foundations Funding Goals Health Professional Health Technology Incidence Intervention Leadership Malignant Female Reproductive System Neoplasm Malignant Neoplasms Medical Research Mission Molecular Biology Monitor NCI-Designated Cancer Center Nature Newly Diagnosed Oklahoma Oncology Pathology Patient-Focused Outcomes Patients Peer Review Physicians Population Prevention Privatization Protocols documentation Reporting Research Research Design Research Personnel Research Training Resource Sharing Rural Safety Science Secure Services Source Statutes and Laws Structure Tissues Training Universities base cancer education cancer health disparity cancer prevention cancer research center director career data management high standard mHealth member mortality multidisciplinary next generation organizational structure pre-clinical programs recruit standard of care translational cancer research treatment research treatment trial

项目摘要

OVERALL – ABSTRACT Oklahoma currently ranks 7th highest among all states for cancer mortality rates, and 2nd in cancer incidence and mortality rates among the 15 states currently without an NCI-designated cancer center. To address this cancer burden, the State passed bipartisan-supported legislation in 2001, directing the University of Oklahoma to create an academic cancer center that would provide statewide leadership in cancer education, prevention, treatment and research. Acting on this mandate, the University established the Stephenson Cancer Center (SCC), a matrix-based academic cancer center with a mission of reducing the burden of cancer in Oklahoma, a catchment area underserved by NCI-designated cancer centers. An essential partner in advancing this mission is the Oklahoma Medical Research Foundation (OMRF), the SCC's proposed consortium partner. Under the leadership of Robert Mannel, MD, who was appointed Director in 2006, the SCC has secured institutional and other commitments totaling $383.7 million of state, university and philanthropic dollars over the past ten years, which have been used to recruit new cancer researchers and oncology physicians, add new physical space, and develop formal research programs and new shared resources. The level of support for the SCC constitutes the largest public – private biomedical initiative ever launched in the State and has resulted in an academic cancer center that has achieved the following benchmarks during the reporting period (CY2016):  $18,371,115 in overall funding base (peer-reviewed, cancer-relevant) (direct costs).  $8,981,794 in NCI research and training funding (direct costs).  $34,234,985 in total funding (direct costs).  96 full and associate members, representing 32 different academic departments.  278,609 sf. of total physical space (research, clinical, administrative).  $33.1 million in annual discretionary funds under the control of the SCC Director.  2,727 newly diagnosed and treated patients, with 612 enrollments on interventional treatment trials. The SCC has developed an organizational structure and environment designed to promote transdisciplinary, team-based science, move ideas along the translational continuum and stimulate research that impacts the SCC catchment area. This structure includes three formal research programs: Preclinical Translational Cancer Research (PTCR), Gynecologic Cancers (GC) and Cancer Prevention and Control (CPC). SCC member research is supported by four formal shared resource facilities: Biostatistics and Research Design, Molecular Biology and Cytometry Research, Tissue Pathology and Mobile Health Technology. Centralized Clinical Protocol and Data Management, Data and Safety Monitoring, and Protocol Review and Monitoring functions oversee and support the SCC's robust clinical trials program.

总体 – 摘要俄克拉荷马州目前的癌症死亡率在所有州中排名第七，癌症发病率排名第二目前没有 NCI 指定癌症中心的 15 个州的死亡率和死亡率。为了减轻癌症负担，该州于 2001 年通过了两党支持的立法，指导俄克拉荷马大学创建一个学术癌症中心，为总统在癌症教育、预防、根据这一任务，大学成立了斯蒂芬森癌症中心。（SCC），一个基于矩阵的学术癌症中心，其使命是减轻俄克拉荷马州的癌症负担， NCI 指定癌症中心服务不足的地区是推进这一使命的重要合作伙伴。是俄克拉荷马州医学研究基金会 (OMRF)，SCC 提议的联盟合作伙伴。在 2006 年被任命为主任的医学博士 Robert Mannel 的领导下，SCC 已确保机构和其他承诺总计 3.837 亿美元的国家、大学和慈善资金过去十年，这十年被用来招募新的癌症研究人员和肿瘤科医生，增加了新的物理空间，并制定正式的研究计划和新的共享资源的支持水平。 SCC 是该州有史以来发起的最大的公私生物医学倡议，并已产生一个学术癌症中心在报告期内（2016 年）达到了以下基准：  总资金基础为 18,371,115 美元（经过同行评审，与癌症相关）（直接成本）。  NCI 研究和培训经费 8,981,794 美元（直接费用）。  资金总额为 34,234,985 美元（直接费用）。  96 名正式和准会员，代表 32 个不同的学术部门。  总物理空间（研究、临床、行政）278,609 平方英尺。  SCC 董事控制下的年度可自由支配资金为 3,310 万美元。  2,727 名新诊断和治疗患者，其中 612 名患者参加了介入治疗试验。 SCC 开发了一个组织结构和环境，旨在促进跨学科、以团队为基础的科学，沿着转化连续体推动思想并刺激影响的研究 SCC 服务范围包括三个正式研究项目：临床前转化癌症研究 (PTCR)、妇科癌症 (GC) 和癌症预防和控制 (CPC) 成员。研究由四个正式共享资源设施支持：生物统计学和研究设计、分子生物学和细胞计数研究、组织病理学和移动医疗技术。方案和数据管理、数据和安全监控以及方案审查和监控功能监督和支持 SCC 稳健的临床试验计划。