The Neural Mechanisms Associated With Alcohol and Cigarette Craving in Alcohol Use Disorder Smokers During Oxytocin Treatment

催产素治疗期间酒精使用障碍吸烟者与酒精和香烟渴望相关的神经机制

基本信息

批准号：
10158379
负责人：
Kimberly Goodyear
金额：
$ 18.07万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-15 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10158379
关键词：
Addictive Behavior Address Alcohol consumption Alcohol dependence Alcohols Anterior Anti-Anxiety Agents Applications Grants Area Behavior Behavioral Blood Pressure Brain Cigarette Cigarette Smoker Clinical Clinical Research Clinical Trials Consumption Cues Dependence Development Development Plans Double-Blind Method Etiology Female Functional Magnetic Resonance Imaging Future Gender Goals Health Heart Rate Heavy Drinking Hormones Human Hypothalamic structure Individual Insula of Reil International Unit Intervention Knowledge Laboratory Study Lead Learning Measures Mentored Research Scientist Development Award Mentors Mentorship Methods Modality Moods National Institute on Alcohol Abuse and Alcoholism Neurosecretory Systems Neurotransmitters Nicotine Oxytocin Participant Pathway interactions Patient Self-Report Peptides Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Physiological Placebos Population Prevalence Probability Randomized Recovery Relapse Research Research Personnel Research Technics Risk Factors Science Signal Transduction Smoke Smoker Smoking Statistical Methods Stress Substance Use Disorder System Testing Throat Cancer Time Tobacco Tobacco Dependence Training Training Activity Ventral Striatum addiction alcohol abuse therapy alcohol craving alcohol cue alcohol relapse alcohol response alcohol seeking behavior alcohol use disorder anxious blood oxygen level dependent brain dysfunction career development cigarette craving cigarette smoke cigarette smoking cingulate cortex comorbidity craving cue reactivity drinking efficacy evaluation experience functional MRI scan gray matter high risk human imaging imaging study improved knowledge base male malignant mouth neoplasm multilevel analysis neuromechanism novel pre-clinical recruit relating to nervous system response sex smoking cessation treatment strategy

项目摘要

PROJECT SUMMARY/ABSTRACT This K01 award will provide the support for the attainment of Dr. Kimberly Goodyear’s long-term goals of contributing to treatment discoveries for individuals with an alcohol and smoking comorbidity and advancing the addiction field with rigorous research techniques. As outlined in this K01 proposal, the training activities will afford Dr. Goodyear with excellent mentorship, training and experience to: 1) To learn how to conduct research involving a clinical trial with individuals with alcohol use disorder (AUD); 2) To learn how to conduct research involving a clinical trial with smokers; 3) To gain knowledge working with oxytocin (OXT) as a novel treatment for AUD smokers; 4) To have a background in neuroendocrine pathways to assess the relationship of OXT with the etiology of alcohol and cigarette use; 5) To learn advanced functional magnetic resonance imaging (fMRI) analysis; and 6) To learn multilevel modeling statistical methods. This K01 proposal is especially salient given the serious health consequences associated with and the prevalence of alcohol drinking and smoking. There is a lack of current treatment options for this comorbid group that signals an exigent need for developing efficacious medications. Recent preclinical and human research suggests that OXT may be a potential treatment for alcohol, smoking and other addictive behaviors due to its anxiolytic, stress reducing and anti- craving effects. This proposed research seeks to examine the behavioral and neural substrates of intranasal OXT compared to placebo on alcohol cue-induced alcohol and cigarette craving in AUD smokers. Non treatment-seeking AUD smokers will be recruited to participate in a between-subjects, placebo-controlled, randomized pilot fMRI study. Participants will undergo an fMRI scan in conjunction with an alcohol-olfactory cue-reactivity task. Secondary assessments will include alcohol and cigarette craving, alcohol and cigarette consumption, physiological measures (heart rate and blood pressure) and mood measures. A team of qualified mentors will support Dr. Goodyear with this comprehensive research plan. This proposed research will address the substantial need for developing new pharmacological treatments by advancing the science knowledgebase to improve interventions for individuals who co-use alcohol and cigarettes. This five-year career development plan will facilitate Dr. Goodyear’s transition to an independent clinical researcher and will assist in laying the groundwork for future treatment strategies and grant applications generated from the findings of this research.

项目概要/摘要该 K01 奖项将为 Kimberly Goodyear 博士实现以下长期目标提供支持：为患有酒精和吸烟共病的个体的治疗发现做出贡献并取得进步正如本 K01 提案中所述，培训活动将在成瘾领域进行严格的研究。为固特异博士提供出色的指导、培训和经验，以： 1) 学习如何进行研究 2）学习如何参与研究 3) 获得使用催产素 (OXT) 作为新型治疗方法的知识对于 AUD 吸烟者；4) 具有神经内分泌通路的背景，以评估 OXT 的关系 5) 学习先进的功能磁共振成像 (fMRI) 分析；以及 6) 学习多级建模统计方法。考虑到饮酒和吸烟对健康造成的严重后果以及饮酒和吸烟的盛行。目前缺乏针对这一共病群体的治疗方案，这表明迫切需要开发最近的临床前和人体研究表明 OXT 可能是一种潜在的药物。由于其抗焦虑、减轻压力和抗抑郁作用，可治疗酒精、吸烟和其他成瘾行为这项拟议的研究旨在检查鼻内的行为和神经基础。 OXT 与安慰剂酒精对非吸烟者提示诱发的酒精和香烟渴望的影响进行比较。寻求治疗的 AUD 吸烟者将被招募参加受试者间、安慰剂对照、随机试点功能磁共振成像研究参与者将接受功能磁共振成像扫描和酒精嗅觉检查。次要评估将包括对酒精和香烟的渴望、酒精和香烟。消耗、生理测量（心率和血压）和情绪测量。导师将支持古德伊尔博士这项全面的研究计划。这项拟议的研究将解决这一问题。迫切需要通过推进科学知识库来开发新的药物治疗方法改善对同时饮酒和吸烟的个人的干预措施这五年的职业发展。该计划将促进固特异博士向独立临床研究员的过渡，并将协助奠定本研究结果为未来的治疗策略和拨款申请奠定了基础。