STRUCTURE OF POSTURE CONTROL

姿势控制结构

• 批准号: 2127860
• 负责人: GIN MCCOLLUM
• 金额: $ 17.11万
• 依托单位: GOOD SAMARITAN HOSP & MED CTR(PRTLND,OR)
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-11 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2127860
• 关键词: biomechanics; biophysics; body movement; hearing; muscle function; neural information processing; posture; sensorimotor system; sensory feedback; somesthesis; touch; vision

The long term goal of this research is to establish a theoretical basis for understanding sensorimotor control in posture, including behavior and its underlying physiology. A focus in the present application will be the relationship of neural activity in the cerebellum to postural control. The methods will be entirely theoretical, and a major objective of the research will be to develop a mathematical structure describing the postural control system. The work will be accomplished with the collaboration of experimental physiologists. To achieve this goal, components of strategies that reduce the number of sensorimotor control parameters will be identified, given a set of task requirements such as maintaining stability. Then the components of strategies will be represented as relations between classes of stimuli and motor commands. Since classes of stimuli can also be equivalent for a population of neurons, populations of neurons will be identified whose activity expresses the same equivalence of classes of stimuli and motor commands. Specifically, patterns of neural activity in the cerebellum will be constructed using receptive field data, in order ultimately to determine to what extent populations of active cells in the cerebellum are directly controlling posture. A mathematical structure will be developed to describe postural control at both the behavioral and the neural-activity levels. Results of this research will clarify the unified nature of postural behavior and its underlying physiology, and will provide a more rational basis for diagnosis and treatment of balance disorders.

这项研究的长期目标是建立理论 理解姿势中感觉运动控制的基础，包括 行为及其基本生理学。 现在的重点 应用将是神经活动的关系 小脑到姿势控制。 这些方法将完全是 理论和研究的主要目标是 开发描述姿势控制的数学结构 系统。 这项工作将通过合作来完成 实验生理学家。 为了实现这一目标，策略的组成部分减少了 将确定感觉运动控制参数的数量，给定 一组任务要求，例如保持稳定性。 然后 策略的组成部分将被表示为 刺激和电机命令的类别。 由于刺激类 对于神经元的种群，人群， 将确定其活性表达相同的神经元 刺激和电机命令类别的等效性。 具体而言，小脑神经活动的模式将 可以使用接收场数据构建，以最终 确定活性细胞中活性细胞种群在多大程度上 小脑直接控制姿势。 数学 结构将开发以描述两者的姿势控制 行为和神经活动水平。 这项研究的结果将阐明 姿势行为及其基本生理学，并将提供 诊断和平衡治疗的更合理的基础 疾病。