Biomimetic Wearable Sensors for Alcohol Monitoring

用于酒精监测的仿生可穿戴传感器

基本信息

批准号：
10154436
负责人：
Benson Fan
金额：
$ 22.47万
依托单位：
CALYX, INC.
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-05 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10154436
关键词：
Adult Affinity Air Alcohol abuse Alcoholic Intoxication Alcoholism Alcohols Atmosphere Automobiles Bacteriophage M13 Bacteriophages Behavior monitoring Binding Biomimetics Biosensor Blood alcohol level measurement Blood specimen Calibration Cellular Phone Clinical Color Consumption Data Databases Detection Development Devices Direct Costs Drug usage Economic Burden Economics Electronics Ethanol Evaluation Facilities and Administrative Costs Fingerprint Gases Genetic Engineering Government Health Health Care Costs Human Humidity Individual Industry Laboratories Libraries Longevity Measures Medical Medical Research Monitor Nitrogen Optics Pattern Phage Display Phase Phase II Clinical Trials Preventive measure Process Production Productivity Proteins Reaction Time Research Resolution Risk Assessment Risk Factors Safety Self Assessment Skin Small Business Innovation Research Grant Surveys System Technology Temperature Testing Thick Time United States Virus Water Wireless Technology Workplace alcohol behavior alcohol measurement alcohol monitoring alcohol risk alcohol sensitivity alcohol use disorder base chemical property cost design disability drinking behavior environmental change high risk drinking innovation innovative technologies interest light weight mortality novel phase 1 study real time monitoring receptor research and development response sensor success tool vapor volatile organic compound wearable device wearable sensor technology

项目摘要

PROJECT SUMMARY According to the 2015 National Survey of Drug Use and Health (NSDUH), 15.1 million adults had alcohol use disorder in the United States. Alcoholism has been identified as an important risk factor for illness, disability, and mortality, carrying a huge economic and societal burden. Real-time, accurate and discreet devices for the assessment of Blood Alcohol Concentration (BAC) are essential to empower medical research with reliable reliable means to monitor alcohol behavior, as well as for effective personal self-assessment. Measurement of ethanol perspired through the skin by means of wearable devices is of particular interest for the possibility to perform discreet and unobtrusive monitoring of BAC, but available devices are still lacking reliability, accuracy and sensitivity. In this context, Bioinspira, Inc. has developed a versatile bacteriophage-based, colorimetric sensor platform technology for gas sensing. The novel, in-house developed technology uses a self-assembling bacteriophage sensor array (M13 bacteriophage) that can be genetically engineered to bind to specific gas molecules and change its color pattern based on type of gas and concentration. By leveraging this innovative technology, through this SBIR phase I study Bioinspira will assess the feasibility of realizing a wearable Biomimetic Sensor for Transdermal Alcohol Monitoring (BiosTAM) for real-time monitoring of ethanol vapor that evaporates through the skin. Preliminary laboratory data showed the ability of BioInspira’s platform technology to detect ethanol. The development of a phage-based ethanol sensor with high will fill a technological gap in alcohol behavior monitoring, enabling more comprehensive and detailed medical studies, and will offer the possibility to monitor and manage personal alcohol use disorder. In SBIR Phase I, the technical feasibility of detecting ethanol vapor selectively, sensitively and real-time will be assessed. To this extent, the following R&D activities will be conducted: 1. Production and evaluation of gas phage array candidates for the selective and sensitive detection of ethanol vapor; 2. Calibration of the best performing phage sensor candidate for the detection of ethanol concentration under different temperature and relative humidity conditions. The results obtained will be preparatory for a SBIR Phase II, where the clinical trials will be performed for the correlation of transdermal alcohol measurements with BAC. Keywords: Alcoholism, Alcohol abuse, wearable biosensor, phage, perspired ethanol, alcohol vapor.

项目概要根据 2015 年全国药物使用与健康调查 (NSDUH)，1510 万成年人饮酒在美国，酗酒已被认为是导致疾病、残疾和残疾的重要危险因素。死亡率，给人们带来巨大的经济和社会负担。血液酒精浓度 (BAC) 的评估对于为医学研究提供可靠的支持至关重要监测酒精行为以及有效的个人自我评估的可靠方法。通过可穿戴设备通过皮肤出汗的乙醇特别令人感兴趣，因为有可能对 BAC 进行谨慎且不引人注目的监测，但现有设备仍然缺乏可靠性和准确性在此背景下，Bioinspira, Inc. 开发了一种基于噬菌体的多功能比色法。用于气体传感的传感器平台技术。这种新颖的内部开发技术采用自组装技术。噬菌体传感器阵列（M13噬菌体）可通过基因工程与特定气体结合分子并根据气体类型和浓度改变其颜色图案。技术，通过这项 SBIR 第一阶段研究 Bioinspira 将评估实现可穿戴设备的可行性用于透皮酒精监测的仿生传感器 (BiosTAM)，用于实时监测乙醇蒸气，初步实验室数据显示了 BioInspira 平台技术的能力。开发基于噬菌体的乙醇传感器将填补该领域的技术空白。酒精行为监测，能够实现更全面、更详细的医学研究，并将提供监测和管理个人酒精使用障碍的可能性在 SBIR 第一阶段，技术可行性。将评估选择性、灵敏且实时地检测乙醇蒸汽的方法，并在此基础上进行以下研发。将开展以下活动： 1. 生产和评估候选气相噬菌体阵列，用于选择性和乙醇蒸气的灵敏检测；2. 最佳性能噬菌体传感器候选物的校准不同温度和相对湿度条件下乙醇浓度的检测。获得的数据将为 SBIR II 期做准备，其中将进行临床试验以确定以下各项的相关性：使用 BAC 进行透皮酒精测量。关键词：酗酒、酒精滥用、可穿戴生物传感器、噬菌体、汗液乙醇、酒精蒸气。