RISK FACTORS IN EARLY HUMAN ATHEROGENESIS

人类早期动脉粥样硬化的危险因素

• 批准号: 3433118
• 负责人: C. ALEX MCMAHAN
• 金额: $ 16.97万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433118
• 关键词: atherosclerosis; atherosclerotic plaque; biomarker; blood lipoprotein; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cholesterol; computer assisted diagnosis; diagnosis design /evaluation; disease /disorder proneness /risk; female; genetic disorder diagnosis; human tissue; postmortem; statistical service /center; thiocyanates; tobacco abuse; young adult human (21-34)

This collaborative project will collect arteries and risk factor data from 1400 young persons 15-34 years of age who die from trauma an dare autopsied in medical examiners' laboratories. The data will be analyzed to determine the associations of the risk factors for adult atherosclerotic disease with the various lesions of atherosclerosis which appear during this age period. These cases will supplement the 1800 cases that are being collected in the ongoing study Pathobiological Determinants of Atherosclerosis in Youth. The major purposes of the additional cases are to (1) obtain an adequate number of cases of women; (2) increase the power of the study to detect associations of risk factors with raised lesions which begin to appear in this age group; and (3) increase the power to detect genetic effects on atherosclerosis. Aortic and coronary artery lesions are measured by visual estimation and by gross and histologic morphometry using computerized image analysis. Risk factor measurements include cholesterol and lipoprotein cholesterol concentration in postmortem serum, thiocyanate in postmortem serum as a marker by analysis of liver DNA. Collection of cases is performed by participating centers in cooperation with local medical examiners; processing of arteries, blood, liver, and other tissue is carried out in central laboratories; and data are managed by a statistical center. This application is for the statistical center component of the project. The Statistical Center will participate in protocol design, receive data from the participating centers, enter the data to computer data files, check the data for errors, monitor the data for protocol violations, and perform intermediate and final statistical analyses.

这个协作项目将从 1400名年轻人15-34岁，因创伤而死 在体检医师的实验室中。 数据将进行分析以确定 成人动脉粥样硬化疾病的风险因素的关联 在此年龄段出现的动脉粥样硬化的各种病变。 这些案件将补充1800例收集的案件 正在进行的研究青年动脉粥样硬化的病理学决定因素。 其他情况的主要目的是（1）获得足够的 妇女病例的数量； （2）增加研究的能力 危险因素与升高病变的关联开始出现 这个年龄段； （3）增加检测遗传影响的能力 动脉粥样硬化。 主动脉和冠状动脉病变是通过视觉估计和通过 使用计算机化图像分析的总体和组织学形态计量学。 风险 因子测量包括胆固醇和脂蛋白胆固醇 在死后血清中的浓度，硫氰酸酯在验尸血清中作为一种 通过分析肝DNA的标记。 案件收集由 与当地医学检查员合作参加中心； 在进行动脉，血液，肝脏和其他组织的处理 中央实验室；数据由统计中心管理。 此应用程序是针对项目的统计中心组成部分。 统计中心将参加协议设计，接收数据 从参与中心，将数据输入到计算机数据文件， 检查数据是否错误，监视数据是否违反协议，然后 执行中级和最终统计分析。