AFRICAN AMERICAN STUDY OF KIDNEY DISEASE

非裔美国人的肾脏疾病研究

• 批准号: 2149053
• 负责人: JACQUES J BOURGOIGNIE
• 金额: $ 29.93万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2149053
• 关键词: African American; antihypertensive agents; blood pressure; cardiovascular disorder chemotherapy; chronic renal failure; clinical trials; cooperative study; glomerular filtration rate; human subject; human therapy evaluation; hypertension; nephrosclerosis

The University of Miami proposes to participate as a clinical center in the African American Study of Kidney Disease (AASK) to compare the efficacy of double-masked administration of randomized antihypertensive drugs on blood pressure control and progressive renal disease. A team of physicians and paramedical personnel, most of whom were involved in the NIH sponsored Modification of Diet in Renal Disease Study and experienced in the longterm care of patients with hypertension and renal disease, is committed to an effective conduct of the Study. An administrative center within the Division of Nephrology and an outpatient clinic center will be dedicated to the AASK Miami team. The Clinical Research Center will be used for patients requiring hospitalization. Laboratory, pharmacy and radiopharmacy support will be provided by the University of Miami Hospital and Clinics. Potentially eligible African-American men and women can be identified on- campus from the Renal and Hypertension, General Medicine, and family Medicine Clinics at the University of Miami/Jackson Memorial Medical Center, and the Renal and Hypertension Clinics at the Miami Veterans Administration Medical Center, and the Clinics of UM Care and Jackson Memorial Medical Center Health Plans. Enrollment of patients will also be sought off-campus from nephrologists in practice, the Association of Black Cardiologists, the Dade County Medical Association, local HMO's, family medicine practice groups, and directly, through local advertisement within the African-American community through newspapers, radio, television, churches, social organizations, and the Dade County School District. The population available and the interest in the Study by patients and physicians alike indicate that 65 selected volunteer patients with hypertension and chronic renal disease from arteriolar nephrosclerosis can be entered, randomized and followed in Miami. The Miami team is committed to accept and implement the common protocol and procedures approved by the Steering Committee and NIDDK staff.

迈阿密大学建议参加临床中心 非裔美国人对肾脏疾病（AASK）的研究，以比较 双掩模的随机抗高血压施用的功效 血压控制和进行性肾脏疾病的药物。 一支由医师和护理人员组成的团队，其中大多数参与其中 在NIH赞助的肾脏疾病研究中饮食的修改和 在患有高血压和肾脏患者的长期护理中经历 疾病致力于有效的研究。 一个 肾脏病和门诊的行政中心 诊所中心将献给迈阿密AASK团队。 临床 研究中心将用于需要住院的患者。 实验室，药房和放射性药物支持将由 迈阿密大学医院和诊所。 可能会在 肾脏和高血压，通用医学和家庭的校园 迈阿密大学/杰克逊纪念医学的医学诊所 中心，以及迈阿密退伍军人的肾脏和高血压诊所 行政医疗中心以及UM Care和Jackson的诊所 纪念医疗中心健康计划。 患者的入学也将是 在实践中寻求肾脏科医生的校园，黑色的关联 心脏病专家，达德县医学协会，当地HMO，家人 医学实践小组，直接通过本地广告 通过报纸，广播，电视，非裔美国人社区 教堂，社会组织和达德县学区。 这 可用人口以及患者对研究的兴趣， 医生都表明65名选定的志愿者患者 小动脉肾细胞化的高血压和慢性肾脏疾病可以 进入，随机分配并在迈阿密进行。 迈阿密团队承诺 接受并实施由 指导委员会和NIDDK工作人员。