RISK FACTORS FOR BREAST LUNG & COLON CANCER IN US BLACKS

乳肺的危险因素

• 批准号: 2096876
• 负责人: Julie R Palmer
• 金额: $ 8.26万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-23 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2096876
• 关键词: African American; alcoholic beverage consumption; antiinflammatory agents; breast neoplasms; cancer information system; cancer risk; colon neoplasms; female; human data; lactation; lung neoplasms; menopause; neoplasm /cancer epidemiology; obesity; oral contraceptives; rectum neoplasms; spontaneous abortion; statistics /biometry; tobacco abuse

There have been only a few epidemiologic studies of risk factors for cancer in black Americans. It has been commonly assumed that information from studies in whites can be generalized to blacks, but this may not be the case. Furthermore, the effectiveness of health promotion and education efforts among blacks may be hampered by the lack of specific evidence about modifiable risk factors from studies of cancer in blacks. In addition, this will strengthen belief in causality. If they are not confirmed, this may lead to identification of the true causal factors. We propose to carry out a series of case-control studies of breast cancer, lung cancer, and large bowel cancer among black women and men. The proposed studies will make use of an already existing large database which has the relevant information on exposures, covariates, and outcomes; it provides the opportunity to learn about risk factors for cancer in blacks at minimal cost. Approximately 800 cases of breast cancer, 275 cases of lung cancer, 300 cases of large bowel cancer, and several thousand controls with other diagnoses will be studied. The incidence of breast cancer is rising faster among black women than white women. We will examine the relation of breast cancer risk to alcohol consumption, oral contraceptive use, induced abortion, cigarette smoking, body size, and lactation, all factors that are influenced by the economic, social, and cultural environment, and that may differ between blacks and whites. The results may help to clarify the etiology of breast cancer and may be useful for cancer prevention in black women. While rates of smoking have declined among blacks, the decline has not been as great as among whites. Recent cigarette marketing campaigns have been specifically aimed at the black community. We will assess cigarette smoking and lung cancer among blacks, including an exploration of the effect of intensity and duration of smoking and of differences in the type of cigarette smoked (tar content and filter). The results of the proposed study may have a greater impact than earlier general reports on the decisions of black Americans regarding smoking. We will also assess two hypotheses regarding large bowel cancer, one of which concerns an adverse effect of alcohol consumption and the other a protective effect of nonsteroidal anti- inflammatory drug use. Both exposures are common and modifiable.

关于癌症危险因素的流行病学研究只有少数 在黑人美国人。 通常认为来自 白人研究可以推广到黑人，但这可能不是 案件。 此外，健康促进和教育的有效性 黑人之间的努力可能会因缺乏有关 黑人癌症研究的可修改风险因素。 此外， 这将加强对因果关系的信念。 如果未得到确认，这个 可能导致鉴定真正的因果因素。 我们建议对乳腺癌进行一系列病例对照研究， 肺癌和黑人妇女和男性大肠癌。 这 拟议的研究将利用已经存在的大型数据库 具有有关暴露，协变量和结果的相关信息；它 提供了学习黑人癌症风险因素的机会 以最小的成本。 大约800例乳腺癌，275例 肺癌，300例大肠癌和数千例对照 将研究其他诊断。 黑人妇女的乳腺癌发生率的增长速度比 白人妇女。 我们将研究乳腺癌风险与酒精的关系 消费，口服避孕药，诱发流产，吸烟，吸烟， 身体大小和哺乳，所有受经济影响的因素， 社会和文化环境，黑人和 白人。 结果可能有助于阐明乳腺癌的病因和 可能对黑人妇女预防癌症有用。 而吸烟率 黑人的下降，下降并不像 白人。 最近的香烟营销活动是专门针对的 在黑人社区。 我们将评估吸烟和肺癌 在黑人中，包括探索强度和 吸烟的持续时间和吸烟类型的差异（焦油 内容和过滤器）。 拟议研究的结果可能具有更大的 对黑人美国人的决定的影响比以前的一般报告 关于吸烟。 我们还将评估两个关于大型的假设 肠癌，其中一种涉及酒精的不利影响 消费量，另一种是非甾体类抗的保护作用 炎症药物使用。 这两种暴露都是常见和可修改的。

项目成果

Induced and spontaneous abortion in relation to risk of breast cancer (United States).

人工流产和自然流产与乳腺癌风险的关系（美国）。

• DOI: 10.1023/a:1018408211089
• 发表时间: 1997
• 期刊: Cancer causes & control : CCC
• 作者: Palmer,JR;Rosenberg,L;Rao,RS;Zauber,A;Strom,BL;Warshauer,ME;Stolley,PD;Shapiro,S
• 通讯作者: Shapiro,S

Oral contraceptive use and breast cancer risk among African-American women.

非裔美国女性口服避孕药的使用和乳腺癌风险。

• DOI: 10.1007/bf00051407
• 发表时间: 1995
• 期刊: Cancer causes & control : CCC
• 作者: Palmer,JR;Rosenberg,L;Rao,RS;Strom,BL;Warshauer,ME;Harlap,S;Zauber,A;Shapiro,S
• 通讯作者: Shapiro,S