PRIMING OF MEMORY AND EFFECTOR CD4 T-CELLS

记忆和效应 CD4 T 细胞的启动

• 批准号: 2089544
• 负责人: KIM BOTTOMLY
• 金额: $ 21.83万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2089544
• 关键词: B lymphocyte; CD antigens; CD4 molecule; T cell receptor; T lymphocyte; animal genetic material tag; antigen presenting cell; antireceptor antibody; cytokine; gene expression; genetically modified animals; immunologic memory; in situ hybridization; laboratory mouse; leukocyte activation /transformation; macrophage; polymerase chain reaction; tissue /cell culture

The activation of CD4 T cells can lead to the generation of antigen experienced cells some of which are effector cells important in the immediate clearance of pathogens and some of which are memory cells important in the rapid elicitation of a response to pathogens encountered previously. The main goal of this proposal is to study the events leading to the generation of antigen experienced CD4 T. Once generated naive and antigen experienced cells will be analyzed for differences in their activation requirements and in the nature of the response elicited. The project will consist of 2 parts: 1) the characterization of phenotypic, functional and biochemical differences between naive, memory and effector CD4 T cells, and 2) the examination of the role of antigen presenting cell types and cytokine expression in the development of effector and memory cells from naive CD4 T cells.

CD4 T细胞的激活可导致抗原的产生 有经验的细胞，其中一些是效应细胞，在 立即清除病原体，其中一些是记忆细胞 对于快速引发对遇到的病原体的反应很重要 之前。该提案的主要目标是研究导致事件 抗原的产生经历了CD4 T。一旦产生幼稚和 将分析经历过抗原的细胞的差异 激活要求和引起的响应的性质。这 项目将由两部分组成：1）表型的表征， 幼稚、记忆和效应器之间的功能和生化差异 CD4 T细胞，以及2)抗原呈递细胞作用的检查 效应器和记忆发育中的类型和细胞因子表达 来自初始 CD4 T 细胞的细胞。