Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma

转化生长因子的调节参与5-氟尿嘧啶和干扰素α-2b联合治疗晚期肝细胞癌的疗效

• 批准号: 15K09020
• 负责人: WANG TING
• 金额: $ 3.08万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09020/
• 关键词: TGF-β; IFN/5-FU 併用療法; HCC; IFNα-2b; 5-FU; ERK1/2; E-cadherin; Claudin-1; 浸潤性肝癌; 化学併用療法; TGFβ

项目成果

Carnosic acid protects normal mouse hepatocytes against H2O2 -induced cytotoxicity via sirtuin 1-mediated signaling.

鼠尾草酸通过 Sirtuin 1 介导的信号传导保护正常小鼠肝细胞免受 H2O2 诱导的细胞毒性。

• DOI: 10.1111/hepr.12563
• 发表时间: 2016
• 作者: Wang T; Takikawa Y.
• 通讯作者: Takikawa Y.

c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes

c-Jun N 端激酶介导的 Rubicon 表达增强肝细胞脂肪凋亡并促进

• DOI: 10.3748/wjg.v22.i28.6509
• 发表时间: 2016
• 作者: Suzuki A; Kakisaka K; Suzuki Y; Wang T; Takikawa Y.
• 通讯作者: Takikawa Y.

Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy.

物理部分肝切除术后肝脏再生过程中的小管反应和局部炎症。

• DOI: 10.1038/labinvest.2016.97
• 发表时间: 2016
• 作者: Suzuki Y; Katagiri H; Wang T; Kakisaka K; Kume K; Nishizuka SS; Takikawa Y.
• 通讯作者: Takikawa Y.

Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma

转化生长因子的调节参与5-氟尿嘧啶和干扰素α-2b联合治疗晚期肝细胞癌的疗效

• DOI: 10.1038/s41420-018-0040-y
• 发表时间: 2018
• 作者: Okada Y;Wang T;Kasai K;Suzuki K;Takikawa Y
• 通讯作者: Takikawa Y