Institute of Translational Health Sciences

转化健康科学研究所

• 批准号: 10595094
• 负责人: Mary L. Disis
• 金额: $ 1051.44万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595094
• 关键词: Alaska; Benchmarking; Big Data; Career Choice; Career Mobility; Child; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Community Health; Competence; Data Science; Disparity; Education; Educational Curriculum; Electronic Health Record; Ensure; Environment; Equity; Faculty; Fostering; Fred Hutchinson Cancer Research Center; Funding; Future; Goals; Growth; Guidelines; Health; Healthcare; Idaho; Individual; Informatics; Infrastructure; Institution; Investments; Laboratories; Leadership; Learning; Location; Longevity; Machine Learning; Methods; Minority Groups; Montana; Pathway interactions; Patients; Performance; Persons; Phase; Policies; Predictive Analytics; Process; Publications; Relationship-Building; Research; Research Personnel; Research Project Grants; Resources; Rewards; Role; Rural Community; Rural Health; Rural Population; Science; Services; Special Population; System; TNFSF15 gene; Technology; Testing; Time; Training; Training and Education; Translational Research; Universities; Vision; Washington; Workforce Development; Wyoming; clinical training; cohort; collaboratory; community engagement; data exploration; data sharing; diversity and equity; doctoral student; early-career faculty; evidence based guidelines; health training; improved; informatics tool; innovation; novel; outreach; pre-doctoral; process improvement; professional students; programs; research to practice; skills; success; tool; translational health science; translational scientist

The Institute of Translational Health Sciences (ITHS) has served as the clinical and translational science hub for Washington, Wyoming, Alaska, Montana, and Idaho (WWAMI) since 2007. The hub brings together 3 top US research institutions as partners: the University of Washington, Seattle Children’s, and the Fred Hutchinson Cancer Research Center. The spokes of the hub are academic, clinical, community-based, and other research organizations across the region. Leveraging networks and relationships built over several years, ITHS will continue to grow and strengthen our regional Collaboratory, a “center without walls”, to promote research that improves the health of the people across WWAMI and beyond. For Workforce Development, there is a strong need for clear career pathways, education, and environments that support professional growth for clinical and translational researchers (CTR) at all levels. ITHS will expand its competency-based TL1 predoctoral program in 2 ways: creation of a cohort at a WWAMI university and with a translational research curriculum to train health professional students during the course of their clinical training. The Institute will establish competency-based training and career advancement pathways for research staff. We will provide a learning system that can produce tailored educational content on-demand and at any time. To enhance Collaboration and Engagement, ITHS will enact team science as an operational standard in CTR, while cultivating a culture that rewards collaboration in faculty promotion. The Institute will integrate community stakeholders at all stages of translational research. We will develop a Rural Health Lab handing the leadership of a research project to a rural community with the aim to tackle a critical community health issue. Integrating Special Populations in research is a challenge. ITHS will promote the growth of a research workforce reflective of the communities served, through outreach, funding support, and training that embeds equity practices into research teams. We will incorporate programs to increase workforce diversity across the Institute. ITHS will reduce barriers to research participation through integration of remote technologies into clinical studies and develop best practices to ensure that “teleresearch” reduces rather than amplifies disparities. Methods and Processes are key to efficiency and quality in research. ITHS supported clinical trials offices have consolidated key functions under a single umbrella, providing opportunities to streamline research processes. We will support study metric tracking across a regional research network, enabling organizations to benchmark performance and collaboratively test and share process improvements. We will develop a pipeline of support for discovery research to ensure more health innovations reach the clinic. Informatics and “big data” drive future innovation. ITHS will make clinical data science more accessible, developing new methods, tools, and education for data exploration, machine learning, and real-world evidence analysis. We emphasize use of the electronic health record to implement evidence-based guidelines in the clinic.

转化健康科学研究所 (ITHS) 已成为临床和转化科学中心 自 2007 年起，华盛顿州、怀俄明州、阿拉斯加州、蒙大拿州和爱达荷州 (WWAMI)。该中心汇集了美国 3 个顶级机构 作为合作伙伴的研究机构：华盛顿大学、西雅图儿童医院和 Fred Hutchinson 癌症研究中心。该中心的核心是学术、临床、社区和其他研究。 ITHS 将利用该地区多年来建立的网络和关系。 继续发展和加强我们的区域合作实验室，一个“没有围墙的中心”，以促进研究 改善 WWAMI 及其他地区人民的健康。 对于劳动力发展，强烈需要清晰的职业道路、教育和环境， 支持各级临床和转化研究人员 (CTR) 的专业发展 ITHS 将扩大其规模。 基于能力的 TL1 博士前计划有两种方式：在 WWAMI 大学创建一个队列并与 转化研究课程，在临床培训过程中培训卫生专业学生。 该研究所将为研究人员建立基于能力的培训和职业发展途径。 将提供一个学习系统，可以随时按需制作定制的教育内容。 为了加强协作和参与，ITHS 将制定团队科学作为 CTR 的运营标准， 同时培养一种奖励教师晋升合作的文化。学院将整合社区。 我们将建立一个农村健康实验室，负责领导转化研究的各个阶段的利益相关者。 一个针对农村社区的研究项目，旨在解决关键的社区健康问题。 将特殊人群纳入研究是一项挑战，ITHS 将促进研究队伍的增长。 通过外展、资金支持和嵌入公平的培训，反映所服务的社区的公平 我们将把提高整个研究所劳动力多样性的计划纳入其中。 ITHS 将通过将远程技术整合到临床研究中来减少参与研究的障碍 并制定最佳实践，以确保“远程研究”减少而不是扩大差距。 方法和流程是 ITHS 支持的临床试验办公室研究效率和质量的关键。 将关键职能整合到一个框架下，为简化研究流程提供了机会。 我们将支持跨区域研究网络的研究指标跟踪，使组织能够进行基准测试 我们将开发一系列支持管道来提高性能并协作测试和共享流程改进。 发现研究，以确保更多的健康创新进入临床。 信息学和“大数据”推动未来创新。ITHS 将使临床数据科学变得更加容易获得、 开发用于数据探索、机器学习和现实世界证据的新方法、工具和教育 我们强调使用电子健康记录在诊所中实施循证指南。