Administrative Core

行政核心

基本信息

批准号：
10595568
负责人：
CYNTHIA N CORNELISSEN
金额：
$ 86.64万
依托单位：
GEORGIA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-25 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10595568
关键词：
Adjuvant Administrator Animals Antigen Targeting Antigens Collaborations Communities Complex Computer Models Creativeness Disease Doctor of Medicine Doctor of Philosophy Engineering Ensure Environment Female Formulation Fostering Funding Goals Gonorrhea Heterogeneity Immunology Infrastructure International Leadership Membrane Proteins Modeling Monitor National Institute of Allergy and Infectious Disease Neisseria gonorrhoeae Nutrient Pathway interactions Process Production Productivity Progress Reports Property Public Opinion Research Research Personnel Resistance Starvation Supervision Surveys Training Transferrin-Binding Proteins United States National Institutes of Health Universities Vaccine Antigen Vaccines Virginia combat experience human subject improved infectious disease model innovation international center male meetings predictive modeling prevent programs rational design recruit reproductive tract research and development success timeline vaccine acceptance vaccine development vaccine discovery vaccine distribution

项目摘要

The overall goal of the International Center for Gonococcal Vaccine Discovery, Formulation and Implementation (ICGV) is to employ our established pipeline for vaccine antigen discovery to optimize the antigenic properties of our selected outer membrane protein antigens as possible vaccine components. Furthermore, our Center will utilize antigen diversity, global strain heterogeneity, and public acceptance information to generate improved computer models that allow us to predict the success of any Ngo vaccine deployed. The infrastructure and collaborations to enable success for projects and cores described in this Center are already in place. The goal of the Administrative Core is to ensure that the ICGV is productive in its goals towards rational engineering of our selected Ngo outer membrane protein antigens and deploying predictive modeling approaches to integrate sequence and strain diversity with public opinion on STI vaccines. The Administrative Core consists of the project and core leadership and a Core Administrator, and this group will be supplemented by a panel of renowned vaccine experts as an external Scientific Advisory Board. The specific aims of the Administrative Core are as follows: Aim 1. Provide coordination, supervision and management that streamlines oversight of Center activities, while incentivizing synergistic and creative approaches to achieving project milestones and objectives. Aim 2. Coordinate regulatory responsibilities of the Center, including human subjects, animal subjects, training, compliance and NIH-related activities including production of progress reports. Aim 3. Foster collaboration with other cores, including planning and supporting multi-Center meetings. Aim 4. Function as an interface between projects, cores, the Scientific Advisory Board, CRC executive committee and NIH/NIAID staff. Aim 5. Establish realistic timelines and monitor progress towards these goals. When necessary, alternative strategies will be implemented to reach the project milestones. Aim 6. Provide financial oversight of all projects and cores. Aim 7. Provide an environment conducive to collaboration among the Core and Project investigators, ensuring investigators receive appropriate recognition for their contributions to this complex team-based project. Aim 8. Implement the Development and Research Program (DRP) to permit a competitive application process that will identify promising young investigators and fund their Ngo-based vaccine development projects that will ultimately feed into our pipeline and modeling. Innovative aspects of the Administrative Core include: the highly experienced PI and the well-established collaborations of PI with the project/core leads; the established pipeline for vaccine antigen discovery; the integration and deployment of an external Scientific Advisory Board; and the supplemental funding for the Development and Research Program committed by the Office of Research and Innovation at Virginia Commonwealth University.

国际淋球菌疫苗发现、配制和制备中心的总体目标实施（ICGV）是利用我们已建立的疫苗抗原发现流程来优化我们选择的外膜蛋白抗原作为可能的疫苗成分的抗原特性。此外，我们的中心将利用抗原多样性、全球菌株异质性和公众接受度生成改进的计算机模型的信息，使我们能够预测任何非政府组织疫苗的成功部署。使本文中描述的项目和核心取得成功的基础设施和协作中心已经到位。行政核心的目标是确保 ICGV 富有成效我们选择的 Ngo 外膜蛋白抗原的合理工程和部署的目标将序列和毒株多样性与公众对性传播感染疫苗的看法结合起来的预测建模方法。行政核心由项目和核心领导层以及核心管理员组成，该小组将由知名疫苗专家小组作为外部科学顾问委员会进行补充。这行政核心的具体目标如下：目标 1. 提供协调、监督和简化对中心活动的监督，同时激励协同作用和创造性实现项目里程碑和目标的方法。目标 2. 协调各监管机构的监管职责中心，包括人类受试者、动物受试者、培训、合规性和 NIH 相关活动包括制作进度报告。目标 3. 促进与其他核心的合作，包括规划和支持多中心会议。目标 4. 充当项目、核心、科学顾问委员会、 CRC 执行委员会和 NIH/NIAID 工作人员。目标 5. 制定切合实际的时间表并监控进展情况朝着这些目标。必要时，将实施替代策略以实现该项目里程碑。目标 6. 对所有项目和核心项目进行财务监督。目标 7. 提供环境有利于核心研究人员和项目研究人员之间的合作，确保研究人员收到对他们对这个复杂的团队项目的贡献给予适当的认可。目标 8. 实施开发和研究计划 (DRP) 允许竞争性申请流程，该流程将确定有前途的年轻研究人员并资助他们基于非政府组织的疫苗开发项目，这些项目最终将满足进入我们的管道和建模。行政核心的创新方面包括： PI 以及 PI 与项目/核心领导的良好合作；已建立的疫苗管道抗原发现；外部科学顾问委员会的整合和部署；和研究和办公室承诺为发展和研究计划提供补充资金弗吉尼亚联邦大学的创新。