20/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT VCU

20/21 ABCD-美国联盟：弗吉尼亚联邦大学研究项目现场

• 批准号: 10594478
• 负责人: James M Bjork
• 金额: $ 156.46万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594478
• 关键词: 10 year old; Address; Adolescence; Adolescent; Affect; Age; Alcohol consumption; Alcohols; Anxiety; Athletic Injuries; Behavior; Bioinformatics; Biological Assay; Brain; Brain imaging; Caffeine; Calendar; Cannabis; Child; Childhood; Clinical assessments; Cognition; Cognitive; Communities; Data; Data Analyses; Decision Making; Development; Emotional; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Ethics; Event; Feeling suicidal; Female; Funding; Genetic; Impairment; Individual; Informatics; Interview; Life; Link; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Monitor; Neurocognition; Neurocognitive; Neuropsychological Tests; Occupations; Outcome; Parents; Participant; Persons; Physical activity; Privatization; Process; Protocols documentation; Psychopathology; Qualifying; Registries; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Schools; Science; Secure; Severities; Siblings; Site; Sleep; Social Functioning; Social isolation; Specific qualifier value; Standardization; Symptoms; Teenagers; Telephone; Text; Time; Tobacco; Tobacco use; Training; Traumatic Brain Injury; Triplet Multiple Birth; Twin Multiple Birth; Universities; Virginia; Youth; adolescent substance use; adverse outcome; assessment application; cognitive development; cognitive testing; cohort; college; design; emerging adult; emotional factor; experience; follow-up; gene interaction; informatics infrastructure; marijuana use; mobile application; mobile computing; multimodality; neural; neurodevelopment; neuroimaging; novel; participant enrollment; participant retention; physical conditioning; recruit; research and development; response; retention rate; substance use; temporal measurement; trend; tv watching

Abstract Neuroimaging has expanded our understanding of brain development from childhood into early adulthood. Adolescent substance use trends have shifted over time, but use of cannabis, alcohol, and tobacco remain prevalent, typically starting during teenage years, when serious mental health conditions also tend to emerge. Although physical health is at its lifetime peak, emerging concerns for teens include increasing rates of depression, anxiety, social isolation, suicidal ideation, and excessive use of screen media. The extent to which early substance use and other environmental exposures may place youth at risk for altered neurodevelopment and adverse outcomes remains poorly understood. A diverse sample of 11,878 9-10 year olds was enrolled from 21 sites across the ABCD Study consortium, and 554 were enrolled at Virginia Commonwealth University (VCU), under RFA-DA-15-015. All participants underwent a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, culture and environment, and mobile monitoring every 2 years. Interim in-person annual interviews and biannual telephone or mobile app assessments provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. Intensive efforts are made to retain the vast majority of participants through adolescence and beyond and retention rates thus far are very high. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental trajectories in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences affect brain development; (5) determine and replicate factors that influence the onset, course, and severity of mental illnesses; (6) characterize the relationship between mental health and substance use; and (7) specify how use of different substances (e.g., cannabis, alcohol, tobacco, caffeine) affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence substance use risk.

抽象的 神经影像学扩展了我们对从童年到成年早期大脑发育的理解。 随着时间的推移，青少年物质使用趋势发生了变化，但大麻、酒精和烟草的使用仍然存在 普遍存在，通常从青少年时期开始，此时也往往会出现严重的心理健康问题。 尽管身体健康正处于一生的巅峰，但青少年面临的新问题包括不断增加的患病率 抑郁、焦虑、社会孤立、自杀意念和过度使用屏幕媒体。程度 早期物质使用和其他环境暴露可能使青少年面临神经发育改变的风险 和不良后果仍然知之甚少。 ABCD 研究联盟从 21 个地点招募了 11,878 名 9-10 岁儿童作为不同样本， 554 名学生根据 RFA-DA-15-015 就读于弗吉尼亚联邦大学 (VCU)。所有参与者 接受了全面的基线评估，包括最先进的脑成像、全面的 神经心理学测试、生物测定、药物使用仔细评估、心理健康、身体健康、 文化与环境，每两年进行一次移动监测。临时面对面年度访谈和 每年两次的电话或移动应用程序评估提供行为、发展、 和生活事件，参与者的负担最小。我们付出了巨大的努力来保留绝大多数 青春期及以后的参与者和迄今为止的保留率非常高。 与科学界安全、私密地共享的数据将使研究人员能够：(1) 描述 神经、认知、情感和学术功能方面的个人发展轨迹，以及 影响因素； （二）制定大脑健康发育国家标准； (3) 调查角色和 基因和环境对发育的相互作用； (4) 检查身体活动、睡眠、屏幕等情况 时间、运动损伤（包括脑外伤）和其他经历会影响大脑发育； (5) 确定并复制影响精神疾病的发作、病程和严重程度的因素； (6) 描述心理健康与物质使用之间的关系； (7) 指定如何使用不同的 物质（例如大麻、酒精、烟草、咖啡因）影响发育结果，以及神经、 认知、情感和环境因素影响物质使用风险。