Investigating neurobehavioral consequences of COVID-19 related stressors on maternal mental health and infant development

调查 COVID-19 相关压力源对孕产妇心理健康和婴儿发育的神经行为影响

基本信息

批准号：
10595011
负责人：
Natalie Hiromi Brito
金额：
$ 70.23万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10595011
关键词：
Animals Behavior Behavioral Biological Brain Buffers COVID-19 COVID-19 impact COVID-19 pandemic COVID-19 pandemic effects COVID-19 stress Caring Child Child Development Chronic stress Collection Communities Contracts Data Data Set Development Disparity Economics Electroencephalography Emotional Enrollment Environment Environmental Risk Factor Equilibrium Event Exposure to Family Financial Support Foundations Future Goals Hair Health Heart Rate Height Human Human Milk Hydrocortisone Individual Infant Infant Development Inflammation Intervention Life Link Long-Term Effects Longitudinal Studies Measures Medical Mental Health Mother-Child Relations Mothers Neurobiology Neurocognition Neurocognitive New York City Outcome Parent-Child Relations Pathway interactions Pattern Perinatal Personal Satisfaction Physiological Population Postpartum Women Pregnancy Pregnant Women Protocols documentation Psychopathology Recording of previous events Research Resources Rest Risk Severities Social support Stress Surveys System Testing Time Toddler United States Virus Woman Work anxious behavior biobehavior brain behavior caregiving cognitive function cohort coronavirus disease early life stress economic impact emotional distress experience gut microbiome gut microbiota improved infancy inflammatory marker interest maternal stress neurobehavioral neurodevelopment neuropsychiatry pandemic disease perinatal period postnatal pregnant prenatal promote resilience prospective protective factors psychosocial public health emergency recruit response social social norm sociodemographic factors sociodemographics stressor transmission process

Animals Behavior Behavioral Biological Brain Buffers COVID-19 COVID-19 impact COVID-19 pandemic COVID-19 pandemic effects COVID-19 stress Caring Child Child Development Chronic stress Collection Communities Contracts Data Data Set Development Disparity Economics Electroencephalography Emotional Enrollment Environment Environmental Risk Factor Equilibrium Event Exposure to Family Financial Support Foundations Future Goals Hair Health Heart Rate Height Human Human Milk Hydrocortisone Individual Infant Infant Development Inflammation Intervention Life Link Long-Term Effects Longitudinal Studies Measures Medical Mental Health Mother-Child Relations Mothers Neurobiology Neurocognition Neurocognitive New York City Outcome Parent-Child Relations Pathway interactions Pattern Perinatal Personal Satisfaction Physiological Population Postpartum Women Pregnancy Pregnant Women Protocols documentation Psychopathology Recording of previous events Research Resources Rest Risk Severities Social support Stress Surveys System Testing Time Toddler United States Virus Woman Work anxious behavior biobehavior brain behavior caregiving cognitive function cohort coronavirus disease early life stress economic impact emotional distress experience gut microbiome gut microbiota improved infancy inflammatory marker interest maternal stress neurobehavioral neurodevelopment neuropsychiatry pandemic disease perinatal period postnatal pregnant prenatal promote resilience prospective protective factors psychosocial public health emergency recruit response social social norm sociodemographic factors sociodemographics stressor transmission process

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项目摘要

PROJECT SUMMARY Societal consequences of the COVID-19 pandemic are unprecedented. The global community has been crippled by a public health emergency that has had deleterious health and economic impacts, the scope of which has yet to be determined. As a result of the current crisis, pregnant women and new mothers are currently experiencing dramatic loss of medical, financial, and social support, resulting in higher rates of emotional distress. It is well established that chronic stress can be embedded in the developing neurobiological system, particularly during sensitive periods of life, but how the timing of maternal stressors and pathways through which these experiences impact child neurobehavioral development are unclear. The central objective of this proposal is to examine the association between perinatal COVID-19 stress and longitudinal postnatal brain development, and to rigorously evaluate timing of exposure, underlying biological mechanisms and postnatal protective factors. We will enroll 300 women and children from the New York City (NYC) COVID-19 Perinatal Experiences (COPE) cohort into a longitudinal protocol that will measure child biobehavioral outcomes at 12-, 24-, and 36-months. The COPE cohort is comprised of more than 900 women that were enrolled into a longitudinal assessment protocol at the height of the pandemic, approximately half of which were pregnant (54%) and half of which were new mothers (46%). The primary aims of this project are to (i) identify key windows of perinatal stress vulnerability; (ii) evaluate biological pathways that underlie associations between maternal COVID-19 stressors and infant neurocognition; and (iii) isolate protective factors in the postnatal environment that promote resilient outcomes in children exposed to extreme perinatal stress. We will selectively recruit the proposed subsample for this study based on balance of timing of exposure, severity of stressors, and sociodemographic factors. We will thus be able to meaningfully evaluate biological consequences of perinatal stress with control over both timing and aggregate risk. Such work would constitute a substantial advance in our understanding of the longitudinal effects of maternal perinatal stress on early human brain development and would also offer potential avenues for promoting healthy outcomes in children born at the height of history’s most significant perinatal stressor.

项目摘要共同19-19大流行的社会后果是前所未有的。全球社区一直是受到有害健康和经济影响的公共卫生紧急紧急事件的瘫痪，范围尚未确定。由于当前的危机，孕妇和新母亲是目前正在遭受医疗，财务和社会支持的巨大丧失，导致较高的比率情绪困扰。众所周知，慢性应激可以嵌入发展中的神经生物学中系统，尤其是在敏感时期，但如何这些经历会影响儿童神经行为的发育尚不清楚。中心目标该建议是检查围产期covid-19应激与纵向后产后之间的关联大脑发育，并严格评估暴露时间，潜在的生物学机制和产后保护因素。我们将招募来自纽约市Covid-19的300名妇女和儿童围产期经验（COPE）队列成一个纵向方案，该方案将测量儿童生物行为成果在12-、24和36个月。 Cope队列由900多名女性组成在大流行高度的纵向评估方案中招募了大约一半怀孕（54％），其中一半是新妈妈（46％）。该项目的主要目的是（i）确定围产期应力脆弱性的关键窗口；（ii）评估基于关联的生物学途径在Mater Covid-19压力源和婴儿神经认知之间；（iii）在促进暴露于极端围产压力的儿童中弹性结局的产后环境。我们将根据暴露时间的平衡，有选择地招募本研究的拟议子样本压力源和社会人口统计学因素。因此，我们将能够有意义地评估生物学围产期应力的后果以及对时间和总风险的控制。这样的工作将构成我们对孕产妇围产压力对早期的纵向影响的理解有很大的进步人脑发育，还将提供潜在的途径来促进儿童健康的结果出生于历史最重要的围产期压力源。