Menstrual-phase-dependent differences in response to chronic variable sleep loss

对慢性可变睡眠缺失的反应存在月经周期依赖性差异

基本信息

批准号：
10595059
负责人：
Shadab A Rahman
金额：
$ 88.84万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10595059
关键词：
Acceleration Acute Address Admission activity Adolescence Attention Awareness Beds Body Temperature Chronic Contraceptive methods Deterioration Drowsiness Endocrine Estradiol Exhibits Exposure to Failure Female Future Goals Gonadal Steroid Hormones Health Hormonal Hormone replacement therapy Hour Impairment Individual Inpatients Intervention Knowledge Longevity Luteal Phase Measures Mediating Menopause Menstrual cycle Outcome Participant Pattern Performance Phase Predisposition Pregnancy Premenopause Progesterone Protocols documentation Randomized Reaction Time Recommendation Recovery Reporting Role Satiation Schedule Scheme Severities Sex Differences Sleep Sleep Deprivation Testing Time Variant Woman Work alertness cognitive performance design female sex hormone improved infertility treatment male men neurobehavioral novel therapeutics performance tests proliferative phase Menstrual cycle response sleep pattern sleep regulation vigilance

项目摘要

Summary It is well known that sleep loss is associated with significant short- and long-term health consequences, but to date the impact of sex differences in response to sleep loss are poorly understood. We and others have shown that women have greater neurobehavioral performance impairment than men when exposed to one night of acute sleep loss. Furthermore, when this effect is examined separately by menstrual cycle phase, women in the follicular phase exhibit greater impairment compared to both men and women during the luteal phase, suggesting a possible endocrine mechanism. Indeed, we have shown that these differences in performance may be driven by sex-steroid-mediated changes in core body temperature (CBT), specifically involving the ratio of progesterone (P4) to estradiol (E2) between the follicular and luteal phases. These findings have important implications for understanding the interactions of sleep loss and female sex hormones on neurobehavioral performance and other health consequences. An important open question, however, is how these menstrual-phase-dependent differences impact performance under more realistic patterns of chronic sleep loss. Millions of women routinely obtain less than the recommended 7-9 hours of sleep per night during the week and attempt to catch up on sleep on the weekend. In men, we have shown that any apparent improvement during such recovery sleep is transient, and that subsequent sleep loss results in more accelerated deterioration in performance. It is unknown how this variable pattern of chronic sleep loss and recovery sleep impacts performance in women during the follicular and luteal phases of the menstrual cycle. The proposed work will fill this important gap in knowledge. In our proposed 11-day inpatient study, healthy premenopausal women will be randomized to either chronic variable sleep deficiency (with a repeated pattern of two nights of 3 hours time-in-bed followed by one night of 10 hours time- in-bed, equivalent to our prior study in mean) or a sleep satiation control (10 hours time-in-bed throughout) during either the follicular or luteal phase of their menstrual cycle. This protocol will allow us to quantify both the impact of chronic variable sleep deficiency on neurobehavioral performance in women and differences in the response to chronic variable sleep loss across the menstrual cycle. We will also investigate the role of CBT, P4, and E2 in mediating these responses. As an exploratory analysis, we will also evaluate the impact of chronic variable sleep loss on E2 and P4 levels to investigate the effect of insufficient sleep on circulating levels of female sex hormones across the menstrual cycle. There is immediate

概括众所周知，睡眠不足与严重的短期和长期健康后果有关，但迄今为止，人们对性别差异对睡眠不足的影响知之甚少。我们和其他人已经表明当女性暴露于一晚的睡眠中时，其神经行为表现受损程度比男性更大急性睡眠不足。此外，当按月经周期阶段单独检查这种效应时，处于月经周期的女性与男性和女性黄体期相比，卵泡期表现出更大的损害，这表明可能的内分泌机制。事实上，我们已经证明这些性能差异可能是由通过性类固醇介导的核心体温（CBT）变化，特别是黄体酮比例 (P4) 在卵泡期和黄体期之间转变为雌二醇 (E2)。这些发现具有重要意义了解睡眠不足和女性性激素对神经行为表现的相互作用其他健康后果。然而，一个重要的悬而未决的问题是，这些月经阶段依赖性如何在更现实的慢性睡眠不足模式下，差异会影响表现。数以百万计的女性经常一周内每晚睡眠时间少于建议的 7-9 小时，并尝试补觉周末。在男性中，我们已经证明，在这种恢复睡眠期间任何明显的改善都是短暂的，随后的睡眠不足会导致表现加速恶化。尚不清楚这是如何慢性睡眠不足和恢复睡眠的不同模式会影响女性在卵泡期和睡眠期的表现月经周期的黄体期。拟议的工作将填补这一重要的知识空白。在我们提出的为期 11 天的住院研究，健康的绝经前女性将被随机分配到慢性可变睡眠组缺乏（重复的模式是两晚 3 小时卧床时间，然后一晚 10 小时卧床时间）床上时间，相当于我们之前的平均研究）或睡眠饱腹感控制（整个过程中 10 小时的床上时间）月经周期的卵泡期或黄体期。该协议将使我们能够量化影响慢性可变睡眠不足对女性神经行为表现的影响以及反应差异整个月经周期中慢性可变的睡眠不足。我们还将研究 CBT、P4 和 E2 在调解这些反应。作为探索性分析，我们还将评估慢性可变睡眠的影响 E2 和 P4 水平下降，以研究睡眠不足对女性性激素循环水平的影响整个月经周期。有即时的