Menstrual-phase-dependent differences in response to chronic variable sleep loss

对慢性可变睡眠缺失的反应存在月经周期依赖性差异

基本信息

批准号：
10595059
负责人：
Shadab A Rahman
金额：
$ 88.84万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10595059
关键词：
Acceleration Acute Address Admission activity Adolescence Attention Awareness Beds Body Temperature Chronic Contraceptive methods Deterioration Drowsiness Endocrine Estradiol Exhibits Exposure to Failure Female Future Goals Gonadal Steroid Hormones Health Hormonal Hormone replacement therapy Hour Impairment Individual Inpatients Intervention Knowledge Longevity Luteal Phase Measures Mediating Menopause Menstrual cycle Outcome Participant Pattern Performance Phase Predisposition Pregnancy Premenopause Progesterone Protocols documentation Randomized Reaction Time Recommendation Recovery Reporting Role Satiation Schedule Scheme Severities Sex Differences Sleep Sleep Deprivation Testing Time Variant Woman Work alertness cognitive performance design female sex hormone improved infertility treatment male men neurobehavioral novel therapeutics performance tests proliferative phase Menstrual cycle response sleep pattern sleep regulation vigilance

项目摘要

Summary It is well known that sleep loss is associated with significant short- and long-term health consequences, but to date the impact of sex differences in response to sleep loss are poorly understood. We and others have shown that women have greater neurobehavioral performance impairment than men when exposed to one night of acute sleep loss. Furthermore, when this effect is examined separately by menstrual cycle phase, women in the follicular phase exhibit greater impairment compared to both men and women during the luteal phase, suggesting a possible endocrine mechanism. Indeed, we have shown that these differences in performance may be driven by sex-steroid-mediated changes in core body temperature (CBT), specifically involving the ratio of progesterone (P4) to estradiol (E2) between the follicular and luteal phases. These findings have important implications for understanding the interactions of sleep loss and female sex hormones on neurobehavioral performance and other health consequences. An important open question, however, is how these menstrual-phase-dependent differences impact performance under more realistic patterns of chronic sleep loss. Millions of women routinely obtain less than the recommended 7-9 hours of sleep per night during the week and attempt to catch up on sleep on the weekend. In men, we have shown that any apparent improvement during such recovery sleep is transient, and that subsequent sleep loss results in more accelerated deterioration in performance. It is unknown how this variable pattern of chronic sleep loss and recovery sleep impacts performance in women during the follicular and luteal phases of the menstrual cycle. The proposed work will fill this important gap in knowledge. In our proposed 11-day inpatient study, healthy premenopausal women will be randomized to either chronic variable sleep deficiency (with a repeated pattern of two nights of 3 hours time-in-bed followed by one night of 10 hours time- in-bed, equivalent to our prior study in mean) or a sleep satiation control (10 hours time-in-bed throughout) during either the follicular or luteal phase of their menstrual cycle. This protocol will allow us to quantify both the impact of chronic variable sleep deficiency on neurobehavioral performance in women and differences in the response to chronic variable sleep loss across the menstrual cycle. We will also investigate the role of CBT, P4, and E2 in mediating these responses. As an exploratory analysis, we will also evaluate the impact of chronic variable sleep loss on E2 and P4 levels to investigate the effect of insufficient sleep on circulating levels of female sex hormones across the menstrual cycle. There is immediate

概括众所周知，睡眠损失与重大的短期和长期健康后果有关，但与对性差异对睡眠损失的影响的影响很少。我们和其他人已经表明在暴露于一个晚上的一晚时，女性的神经行为表现障碍比男性更大急性睡眠损失。此外，当通过月经周期阶段分别检查这种效果时，与黄体期相比，与男性和女性相比，卵泡期表现出更大的损害，表明可能的内分泌机制。确实，我们已经表明，这些性能上的这些差异可能会被驱动通过性类固醇介导的核心体温（CBT）的变化，特别涉及孕酮的比率（P4）到卵泡和黄体相之间的雌二醇（E2）。这些发现对了解睡眠丧失和女性性激素在神经行为表现上的相互作用其他健康后果。但是，一个重要的开放问题是这些月经相关的如何差异会影响更现实的慢性睡眠损失模式。常规数百万妇女在一周中每晚的每晚睡眠时间少于建议的7-9个小时，并尝试赶上睡眠周末。在男性中，我们已经表明，这种恢复睡眠期间的任何明显改善都是短暂的，随后的睡眠损失导致性能的加速恶化。这是未知的慢性睡眠丧失和恢复睡眠的可变模式会影响卵泡期间女性的表现月经周期的黄体阶段。拟议的工作将填补知识的这一重要差距。在我们的建议中 11天的住院研究，健康的绝经前妇女将被随机分为慢性可变睡眠缺乏症（重复的模式为两个晚上3个小时的床，然后是10个小时的晚上 - 在床上，等同于我们先前的平均研究）或睡眠饱腹感控制（整个床位10小时）月经周期的卵泡或黄体期。该协议将使我们能够量化影响女性神经行为表现的慢性可变睡眠不足和反应差异在整个月经周期中慢性变化的睡眠损失。我们还将研究CBT，P4和E2在调解这些反应。作为探索性分析，我们还将评估慢性变量睡眠的影响 E2和P4水平的损失，以研究睡眠不足对循环水平的女性性激素的影响在月经周期中。有即时