Shared Resource 09: Leukemia Tissue Bank (LTBSR)

共享资源 09：白血病组织库 (LTBSR)

• 批准号: 10553341
• 负责人: Lapo Alinari
• 金额: $ 10.01万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-12 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553341
• 关键词: Abbreviations; Address; Biocompatible Materials; Biometry; Biopsy; Blood; Bone Marrow; Budgets; CD34 gene; Cancer Biology; Cancer Center Support Grant; Cancer Control; Cancer Hospital; Cancer Survivorship; Cell Survival; Chemoprevention; Clinic; Clinical; Clinical Data; Clinical Research Protocols; Clinical Treatment; Clinical Trials; Clip; Collaborations; Collection; Comparative Pathology; Comprehensive Cancer Center; Consent; Cryopreservation; DNA; Data; Electronics; Equipment and supply inventories; Evaluation; Experimental Hematology; Flow Cytometry; Fostering; Funding; Genetic; Genetic Materials; Genomics; Grant; Hematological Disease; Hematology; Hematopoietic stem cells; Immune; Immunologic Monitoring; Immunooncology; Immunophenotyping; Institution; Institutional Review Boards; Intervention; Intramural Research Program; Laboratories; Leukapheresis; Liquid substance; Location; Lymphoma; Marrow; Mentored Clinical Scientist Development Program; Microscopy; Molecular Carcinogenesis; Multiple Myeloma; NCI Center for Cancer Research; Nitrogen; Nutrient; Ohio; Oncology; Operative Surgical Procedures; Outcome; Pathologic; Pathology; Patients; Pediatric Hospitals; Pharmaceutical Chemistry; Phenotype; Phytochemical; Procedures; Process; Proteins; Proteomics; Protocols documentation; Publications; Published Comment; Quality Control; Research; Research Institute; Research Personnel; Research Priority; Resource Sharing; Resources; Sampling; Services; Source; Stromal Cells; Structure of nail of finger; Surveys; System; Techniques; Tissue Procurements; Translational Research; Umbilical Cord Blood; Universities; animal imaging; biobank; biomedical informatics; bone; cancer care; cancer prevention; clinical translation; digital imaging; genomic data; hip bone; improved; leukemia; leukemia tissue bank; lymph nodes; material transfer agreement; member; next generation sequencing; pathology imaging; population based; programs; recruit; sample collection; senior faculty; standard of care; translational genomics; translational therapeutics

PROJECT SUMMARY – LEUKEMIA TISSUE BANK SHARED RESOURCE (LTBSR) The LTBSR is a longstanding biobank, established in 1997, that procures, processes, and stores biologic material from consenting patients with hematologic diseases. The LTBSR procures samples in two ways: 1) via a general biobanking protocol for future research; and 2) via specific clinical research protocols with special collection needs. The major services of the LTBSR are consenting patients, procuring samples (e.g., blood, bone marrow, and leukapheresis products) as directed by the general or a specific IRB protocol, assessing sample quality, providing fresh samples to investigators or processing them for storage, providing an oversight process for use of samples and data, and delivering samples and data to approved recipients. Investigators receive samples identified phenotypically or genetically, along with clinical data and available pathology data (including standard of care immunophenotyping and genetic sequencing panels). During the current cycle, Dr. Lapo Alinari (LR) replaced the prior LTBSR Director (David Lucas, who moved from Columbus), and Dr. Robert Baiocchi (LR) replaced Dr. Clara Bloomfield (LR) as the Senior Faculty Advisor. The Specific Aims of the LTBSR are to: 1) consent subjects and procure samples from patients with hematologic diseases; 2) uniformly process, characterize and store biospecimens using state-of-the art procedures; and 3) provide biospecimens with associated clinical, pathological and genomic data to OSUCCC researchers and to outside institutions so that they can correlate findings from patient samples with clinical or population-based outcomes. Over the current grant cycle, the LTBSR has supported 67 investigators (75% OSUCCC members) and all five of the OSUCCC research programs, 45 publications (11 > 10 impact factor) and 19 NCI grants, including 1 K12, 1 K22, 1 K23, 1 P01, 13 R01s, and 2 R35s. The OSUCCC has recently made a commitment to substantially increase samples obtained by lymph node sampling from lymphoma patients. In addition, the LTBSR has expanded services for collecting discarded normal hipbone from replacement surgeries as a source of marrow stromal cells and umbilical cord blood as a source of CD34+ hematopoietic stem cells. In the next funding cycle, the LTBSR will continue to expand its breadth of tissue procurement services, addressing the OSUCCC research priorities of immuno-oncology, translational genomics, and cancer prevention and survivorship. The annual budget of the LTBSR is $664,631, yet the CCSG request is $70,451. Thus, the LTBSR leverages extensive institutional support and seeks only 10.6% support from CCSG funds.

项目摘要 - 白血病组织共享资源（LTBSR） LTBSR是一家长期存在的生物库，成立于1997年，可以采购，过程和存储生物学 同意血液学疾病患者的材料。 LTBSR通过两种方式采购样品：1）通过 一般的生物库协议，用于未来的研究； 2）通过特殊的特定临床研究方案 收集需求。 LTBSR的主要服务是同意患者，采购样本（例如，血液，骨骼 按照一般或特定的IRB协议指示 质量，向调查人员提供新鲜样品或处理存储，提供监督过程 用于使用样品和数据，并将样本和数据传递给批准的收件人。调查人员收到 样本通过遗传或遗传鉴定，以及临床数据和可用病理数据（包括 护理标准免疫表型和遗传测序面板）。在当前周期中，Lapo Alinari博士 （LR）取代了先前的LTBSR董事（从哥伦布搬迁的David Lucas）和Robert Baiocchi博士（LR） 取代了Clara Bloomfield博士（LR）为高级教师顾问。 LTBSR的具体目的是：1） 同意受试者并从血液学疾病患者那里采购样本； 2）统一的过程， 使用最先进的程序来表征和存储生物测量； 3）为生物测量提供 与OSUCCC研究人员以及外部机构相关的临床，病理和基因组数据，以便 它们可以将患者样本的发现与临床或基于人群的结果相关联。超过电流 赠款周期，LTBSR支持了67名调查人员（75％OSUCCC成员）和所有五个OSUCCC 研究计划，45个出版物（11> 10个影响因素）和19个NCI赠款，包括1 K12、1 K22、1 K23、1 P01、13 R01和2 R35。 OSUCCC最近致力于大大增加样品 通过淋巴瘤患者的淋巴结采样获得。此外，LTBSR扩大了服务 从替换手术中收集丢弃的正常髋骨作为骨髓基细胞的来源和 脐带血作为CD34+造血干细胞的来源。在下一个资金周期中，LTBSR将 继续扩大其组织采购服务的广度，以解决OSUCCC的研究重点 免疫肿瘤学，转化基因组学以及癌症预防和生存。年度预算 LTBSR为$ 664,631，但CCSG请求为$ 70,451。这是LTBSR利用广泛的机构 支持并仅寻求CCSG基金的10.6％的支持。